Publicaciones/Publications

W. J. McDaid, L. Wilson, H. Adderley, A. Martinez‑Lopez, M. J. Baker, J. Searle, L. Ginn, T. Budden, M. Aldea, A. Marinello, J. V. Aredo7 A. Viros, B. Besse, H. A. Wakelee, F. Blackhall, S. Castillo‑Lluva, C. R. Lindsay and A. Malliri. 2024. The PI3K‑AKT‑mTOR axis persists as a therapeutic dependency in KRASG12D‑driven non‑small cell lung cancer. Molecular Cancer. 23:253. https://doi.org/10.1186/s12943-024-02157-x

Angelica Martínez-López, Guiomar Infante, Marina Mendiburu-Eliçabe, Andrés Machuca, Olga M. Antón, Mónica González-Fernández, José L. Luque-García, Robert B. Clarke & Sonia Castillo-Lluva (AC). 2024. SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts. Cellular Oncology. Springer. https://doi.org/10.1007/s13402-024-01005-w

Andres Machuca; Gabriel A. Peñalver; Roberto Alvarez-Fernandez Garcia; Angelica Martinez-Lopez; Sonia Castillo-Lluva; Estefania Garcia-Calvo; Jose L. Luque-Garcia. 2024. Advancing rhodium nanoparticle-based photodynamic cancer therapy: quantitative proteomics and in vivo assessment reveal mechanisms targeting tumor metabolism, progression and drug resistance. Journal of Materials Chemistry B. https://doi.org/10.1039/D4TB01631A 

Guillermo Aragoneses-Cazorla; Roberto Alvarez-Fernandez Garcia; Angelica Martinez-Lopez; Milagros Gomez Gomez; Maria Vallet-Regí; Sonia Castillo-Lluva; Blanca González; Jose L. Luque-Garcia. 2024. Mechanistic insights into the antitumoral potential and in vivo antiproliferative efficacy of a silver-based core@shell nanosystem. International Journal of Pharmaceutics. Elsevier. 655.

doi: 10.1016/j.ijpharm.2024.124023

Marina Mendiburu-Eliçabe; Natalia García-Sancha; et.al; Jesús Pérez-Losada; Sonia Castillo-Lluva (AC). 2024. NCAPH Drives Breast Cancer Progression and Identifies a Gene Signature that Predicts Luminal A Tumor Recurrence. Clinical and Translational Medicine. JOHN WILEY & SONS LTD. 14-2, pp.1-25. 

doi: 10.1002/ctm2.1554

Angélica Martínez-López; Ana García-Casas; Guiomar Infante; et al; (12/12) Sonia Castillo-Lluva (AC). 2024. POTEE promotes breast cancer cell malignancy by inducing invadopodia formation through the activation of SUMOylated Rac1. Molecular Oncology. JOHN WILEY & SONS LTD. 18, pp.620-640. 

doi: 10.1002/1878-0261.13568

Taewoo Kim; Jessica M Johnston; Sonia Castillo-Lluva; et al; Endre Kiss-Toth. (3/13). 2022. TRIB1 regulates tumor growth via controlling tumor-associated macrophage phenotypes and is associated with breast cancer survival and treatment response. Theranostics. 12-8, pp.3584-3600. 

doi: 10.7150/thno.72192

A. Martínez-López; A. García-Casas; Paloma Bragado; A. Orimo; E. Castañeda-Saucedo; S. Castillo-Lluva (AC). 2021. Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumour development through IL-1β upregulation. Cancer Letters. Elsevier. 521, pp.14-28. 

https://doi.org/10.1016/j.canlet.2021.08.014 

Alba Orea-Soufi; Castillo-Lluva, S; Nélida Salvador-Tormo et al., 2021. The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer. Cancers. MDPI. 13-21, pp.5307.

doi: 10.3390/cancers13215307

Klionsky, D.J. et. al; 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy. Taylor & Francis. 17-1, pp.1-382. 

doi: 10.1080/15548627.2020.1797280. 

Blanco-Gomez A; Hontecillas-Prieto, L; Corchado-Cobos R; et al; Castillo-Lluva S (AC); 2020. Stromal SNAI2 Is Required for ERBB2 Breast Cancer Progression Cancer Research. American Association for Cancer Research. 80-23, pp.5216-5230. 

doi: 10.1158/0008-5472.CAN-20-0278

M Brackett C; Garcia-Casas A; Castillo-Lluva S; Blagg BSJ. 2020. Synthesis and Evaluation of Ginkgolic Acid Derivatives as SUMOylation Inhibitors. ACS Med Chem Lett. ACS publications. 11-11, pp.2221-2226. 

doi/10.1021/acsmedchemlett.0c00353

Lorente M; García-Casas A; Salvador N; Martínez-López A; Gabicagogeascoa E; Velasco G; López-Palomar; S. Castillo-Lluva (AC). 2019. Inhibiting SUMO1-mediated SUMOylation induces autophagy mediated cancer cell death and reduces tumour cell invasion via RAC1 Journal of Cell Science. The Company of Biologists Ltd. 132-20, pp.1-12.

doi: 10.1242/jcs.234120. 

Belen Garcia-Fojeda; Zoe González-Carnicero; Alba de Lorenzo, Carlos; Castillo-Lluva, S et al; Cristina Casals. 2019. Lung Surfactant Lipids Provide Immune Protection Against Haemophilus influenzae Respiratory Infection. Frontiers in Immunology. 10-458, pp.1-16.

doi: 10.3389/fimmu.2019.00458. 

Sáez-Freire, MDM; (2/17) Blanco-Gómez; Sonia Castillo-Lluva; et al; Pérez-Losada J. 2018. Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness. Data in Brief. Elsevier. 18, pp.1172-1184.

doi: 10.1016/j.dib.2018.03.132

Sáez-Freire, MDM; (2/17) Blanco-Gómez; Sonia Castillo-Lluva; et al; Pérez-Losada J. 2018. The biological age linked to oxidative stress modifies breast cancer aggressiveness. Free Radic Biol Med.Elsevier. 120, pp.133-146.

https://doi.org/10.1016/j.freeradbiomed.2018.03.012 

Natalia García-Sancha; Roberto Corchado-Cobos; Aurora Gómez-Vecino; et al; Jesús Pérez-Losada. 2022. Evolutionary Origins of Metabolic Reprogramming in Cancer. International Journal o f Molecular Sciences. MDPI. 23, pp.12063.

doi: 10.3390/ijms232012063

Roberto Corchado Cobos; Natalia García-Sancha; Marina mendiburu-eliçabe; et al; (11/11) Sonia Castillo-Lluva (AC) Jesus Perez-Losada.. 2022. Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer. Cancers. Basis. 14-2, pp.322.

doi: 10.3390/cancers14020322 

Sonia Castillo-Lluva; Adrian Blanco-Gomez; María del Mar Saez-Freire; Lourdes Hontecillas-Prieto; Jian Hua Mao; Andres Castellanos-Martín; Jesus Perez-Losada. 2016. Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes. BioEssays. WILEY Periodicals, Inc. 38-7, pp.664-673.

doi: 10.1002/bies.201600084

Clara Andradas; Sandra Blasco-Benito; Sonia Castillo-Lluva; et al; Cristina Sánchez. 2016. Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast

cancer. ONCOTARGET. Jul 26;7(30):47565-47575. 

doi: 10.18632/oncotarget.10206.

Castillo-Lluva, S; Hontecillas-Prieto, L; Blanco-Gómez, A; Sáez-Freire, MM; Mao JH; Castellanos-Martín A; Pérez-Losada, J. 2015. A new role of SNAI2 in post-lactational involution of the mammary gland links it to luminal breast cancer development. ONCOGENE.  34, pages4777–4790 

doi:10.1038/onc.20.

Castellanos-Martín, A; Castillo-LLuva, S; Sáez-Freire Mdel M; et al; Pérez-Losada J. 2015. Unraveling heterogeneous susceptibility and the evolution of breast cancer using a systems biology approach. Genome Biology. 16-1, pp.40.

Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH. Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nat Commun. 2013;4:2180. 

doi: 10.1038/ncomms3180. 

Castillo-Lluva, S.; Tan, C-T; Daugaard, M.; Sorensen, P. H. B.; Malliri, A. 2013. The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation. ONCOGENE. 32-13, pp.1735-1742. ISSN 0950-9232. 

doi: 10.1038/onc.2012.189. 

Mack, Natalie A.; Whalley, Helen J.; Castillo-Lluva, Sonia; Malliri, Angeliki. 2011. The diverse roles of Rac signaling in tumorigenesis. CELL CYCLE. 10-10, pp.1571-1581. ISSN 1538-4101.

doi: 10.4161/cc.10.10.15612

Castillo-Lluva, S; Tatham, MH.; Jones, RC.; Jaffray, EG.; Edmondson, RD.; Hay, RT.; Malliri, A. 2010. SUMOylation of the GTPase Rac1 is required for optimal cell migration. NATURE CELL BIOLOGY. 12-11, pp.1078-U70. ISSN 1465-7392.

https://doi.org/10.1038/ncb2112 

Castillo-Lluva, Sonia; Perez-Martin, Jose. 2007. Connections between polar growth and cell cycle arrest during the induction of the virulence program in the phytopathogenic fungus Ustilago maydis. PLANT SIGNAL BEHAV. 3-7, pp.480-481. ISSN1040-4651.

doi: 10.4161/psb.3.7.5680

Flor-Parra, I; Castillo-Lluva, S; Perez-Martin, J. 2007. Polar growth in the infectious hyphae of the phytopathogen Ustilago maydis depends on a virulence-specific cyclin. PLANT CELL. 19-10, pp.3280-3296. ISSN 1040-4651.

doi: 10.1105/tpc.107.052738 

Castillo-Lluva, Sonia; Alvarez-Tabares, Isabel; Weber, Isabella; Steinberg, Gero; Perez-Martin, Jose. 2007. Sustained cell polarity and virulence in the phytopathogenic fungus Ustilago maydis depends on an essential cyclin-dependent kinase from the Cdk5/Pho85 family. JOURNAL OF CELL SCIENCE. 120-9, pp.1584-1595. ISSN0021-9533.

doi: 10.1242/jcs.005314

Perez-Martin, J; Castillo-Lluva, S; Sgarlata, C; Flor-Parra, I; Mielnichuk, N; Torreblanca, J; Carbo, N. 2006. Pathocycles: Ustilago maydis as a model to study the relationships between cell cycle and virulence in pathogenic fungi. MOLECULAR GENETICS AND GENOMICS. 276-3, pp.211-229. ISSN 1617-4615.

Castillo-Lluva, S; Perez-Martin, J. 2005. The induction of the mating program in the phytopathogen Ustilago maydis is controlled by a G1 cyclin. PLANT CELL. 17-12, pp.3544-3560. ISSN 1040-4651.

doi: 10.1105/tpc.105.036319

Garrido, E; Voss, U; Muller, P; Castillo-Lluva, S; Kahmann, R; Perez-Martin, J. 2004. The induction of sexual development and virulence in the smut fungus Ustilago maydis depends on Crk1, a novel MAPK protein. GENES & DEVELOPMENT. 18-24, pp.3117-3130. ISSN 0890-9369.

doi: 10.1101/gad.314904

Castillo-Lluva, S; Garcia-Muse, T; Perez-Martin, J. 2004. A member of the fizzy-related family of APC activators is regulated by cAMP and is required at different stages of plant infection by Ustilago maydis. JOURNAL OF CELL SCIENCE. 117-18, pp.4143-4156. ISSN 0021-9533.

doi: 10.1242/jcs.01304

del Pino, MR; Moreno, A; de Lacoba, MG; Castillo-Lluva, S; Gilardi, P; Serra, MT; Garcia-Luque, I. 2003. Biological and molecular characterization of P101 isolate, a tobamoviral pepper strain from Bulgaria. ARCHIVES OF VIROLOGY. 148-11, pp.2115-2135. ISSN 0304-8608.

doi: 10.1007/s00705-003-0176-8