I am a postdoctoral researcher under Professor Austin Roorda at UC Berkeley. My primary interest lies in adaptive optics (AO) and phase-resolved optical coherence tomography (OCT) for studying retinal signals in human eyes. This field is known as optoretinography (ORG). By employing these techniques along with a combined AOSLO imaging setup, our research aims to investigate nanometer-scale changes in retinal signals at the single-cell level when exposed to eye motions, in an all-optical and non-invasive manner in human subjects. The underlying interferometry principle, widely recognized for detecting gravitational waves in astrophysics, fuels our curiosity to identify subtle signal changes in the micro-world.
My previous doctoral research at UC Irvine also centered on eye studies, specifically in the areas of surgery and diagnostics:
We are pioneers on a global scale, investigating high-tech femtosecond lasers to push the boundaries of a completely non-invasive, non-incisional glaucoma treatment. Our proposed method is called femtosecond laser trabeculotomy (FLT), which eliminates the need to open the eye during surgery.
To put it in perspective, one femtosecond is to one second what one second is to approximately 32 million years. This revolutionary technology, used in eye samples, results in no collateral tissue damage, as demonstrated by various high-resolution imaging modalities such as OCT, second harmonic generation microscopy, and histology imaging. Additionally, we utilize OCT imaging to evaluate the creation of FLT outflow channels in human cadaver eyes and determine the optimal pulse energy for the clinical translation of our innovative technology.
Our research interests, conducted under the supervision of Professor Tibor Juhasz, focus on:
1) femtosecond laser trabeculoctomy (FLT): a novel, non-invasive, non-incisional glaucoma treatment.
2) OCT dispersion compensation.
3) iridocorneal angle OCT imaging.
We are also interested in Meibomian Gland Dysfunction (MGD), a prevalent cause of dry eye, working with Professor James Jester to answer the following two fundamental questions:
1) What causes MGD? By modeling the meibum section through the terminal duct of the gland, we found that increased meibum viscosity, decreased duct diameter, and weakening of the eyelid pressure on the meibomian glands all show potential for dramatically affecting the secretion of meibum. Paper can be found here.
2) How to treat MGD? We proposed a novel method called selective photothermal ablation (SPA) for MGD treatment. coming soon...
News!
April 2024: Our paper, titled "Evaluating the effect of pulse energy on femtosecond laser trabeculotomy (FLT) outflow channels for glaucoma treatment in human cadaver eyes," has been published in Lasers in Surgery and Medicine, the official journal of the American Society for Laser Medicine & Surgery.
Mar 2024: Our abstract, titled "Real-time Stabilization of AOOCT Enabling Efficient ORG for Cone Classification," has been accepted for presentation at the ARVO Imaging in the Eye Conference on May 4 in Seattle, Washington.
Jan 2024: Our two abstracts, titled "Modeling Meibum Secretion: Alternatives for Obstructive Meibomian Gland Dysfunction (MGD)" and "Selective Photothermal Ablation (SPA) of Meibomian Glands Using a High Intensity 1726 nm Laser," have been accepted for the 2024 ARVO meeting (May 5-9) in Seattle, Wash.
Dec 2023: Our MGD modeling paper is published in Journal of The Ocular Surface (IF=6.4).
Oct 2023: Shangbang Luo passed his PhD defense ! Thesis can be found here.
Sep 2023: Our review paper on cornea crosslinking is accepted to Journal of The Ocular Surface !
Aug 2023: Our paper, which utilizes OCT for imaging the iridocorneal angle details, has been published in Scientific Reports. This paper might be of great interest to glaucoma specialists and glaucoma surgery companies.
July 2023:
The recipients of the 2023 ASLMS Research Grants have been announced, and we are delighted to congratulate Shangbang Luo for receiving a student research grant!
June 2023: Congratulations! Shangbang has received a Travel Grant Award from the Associated Graduate Students at UCI.
June 2023: Our ARVO 2023 abstract entiled "Evaluating the Effect of Pulse Energy on Femtosecond Laser Trabeculotomy (FLT) Drainage Channels in Human Cadaver Eyes" is now out online.
June 2023: Shangbang Luo will be giving a seminar talk entitled "Advancing Next-Generation Laser Eye Surgeries for Glaucoma and Meibomian Gland Dysfunction" at the McDonnell Douglas Engineering Auditorium at UC Irvine on June 9th from 12:30 to 1:00 pm. We cordially invite you to join us for this informative session.
Feb 2023: Our abstract entiled "Evaluating the Effect of Pulse Energy on Femtosecond Laser Trabeculotomy (FLT) Drainage Channels in Human Cadaver Eyes" has been accepted for presentation during the 2023 ARVO Annual Meeting.
Jan 2023: Shangbang received a $5,000 student research grant from American Society for Laser Medicine and Surgery (ASLMS). Congratulations!
Nov 2022: Congratulations to Shangbang Luo on receiving the Henry Samueli Endowed Fellowship Award from the Henry Samueli School of Engineering at UCI! Samueli Fellows are selected based on academic record, as well as for compelling research projects with an outstanding potential for broader impacts within medicine and bioengineering.
May 2022: Our first OCT paper entitled "Dispersion compensation for spectral domain optical coherence tomography by time-frequency analysis and iterative optimization" was published in Optics Continuum. Cheers!
Mar 2021: Congratulations! Shangbang passed the PhD qualifying exam!
Jan 2021: Shangbang Luo is invited to give a presentation at ViaLase Inc., "Spectroscopic Optical Coherence Tomography (SOCT) –– an Effort To Explore Additional Dimension To Provide Functional Information Without Hardware Modifications".
Nov 2020: Our web is open to the public!