Publications

Wohlgemuth RP, Feitzinger RM, Henricson KE, Dinh DT, Brashear SE, Smith LR. The extracellular matrix of dystrophic mouse diaphragm accounts for the majority of its passive stiffness and is resistant to collagenase digestion. Matrix Biol Plus. 2023 Mar 13;18:100131. doi: 10.1016/j.mbplus.2023.100131. PMID: 36970609; PMCID: PMC10036937.

Brashear SE, Wohlgemuth RP, Hu LY, Jbeily EH, Christiansen BA, Smith LR. Collagen cross-links scale with passive stiffness in dystrophic mouse muscles, but are not altered with administration of a lysyl oxidase inhibitor. PLoS One. 2022 Oct 27;17(10):e0271776. doi: 10.1371/journal.pone.0271776. PMID: 36302059; PMCID: PMC9612445.

Loomis, T., Hu, LY., Wohlgemuth, R.P. et al. Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts. Sci Rep 12, 13582 (2022). https://doi.org/10.1038/s41598-022-17852-2

Hu LY, Mileti CJ, Loomis T, Brashear SE, Ahmad S, Chellakudam RR, Wohlgemuth RP, Gionet-Gonzales MA, Leach JK, Smith LR. Skeletal Muscle progenitors are sensitive to collagen architectural features of fibril size and crosslinking. Am J Physiol Cell Physiol. 2021 Jun 30. doi: 10.1152/ajpcell.00065.2021. Epub ahead of print. PMID: 34191625.

Brashear SE, Wohlgemuth RP, Gonzalez G, Smith LR. Passive stiffness of fibrotic skeletal muscle in mdx mice relates to collagen architecture. J Physiol. 2021 Feb;599(3):943-962. doi: 10.1113/JP280656. Epub 2020 Dec 18. PubMed PMID: 33247944.

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Chen D, Smith LR, Khandekar G, Patel P, Yu CK, Zhang K, Chen CS, Han L, Wells RG. Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization. Sci Rep. 2020 Nov 4;10(1):19065. doi: 10.1038/s41598-020-76107-0. PubMed PMID: 33149218; PubMed Central PMCID: PMC7642422.

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Smith LR, Meyer GA. Skeletal muscle explants: ex-vivo models to study cellular behavior in a complex tissue environment. Connect Tissue Res. 2020 May-Jul;61(3-4):248-261. doi: 10.1080/03008207.2019.1662409. Epub 2019 Sep 6. PubMed PMID: 31492079.

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Smith LR, Kok HJ, Zhang B, Chung D, Spradlin RA, Rakoczy KD, Lei H, Boesze-Battaglia K, Barton ER. Matrix Metalloproteinase 13 from Satellite Cells is Required for Efficient Muscle Growth and Regeneration. Cell Physiol Biochem. 2020 Apr 11;54(3):333-353. doi: 10.33594/000000223. PubMed PMID: 32275813; PubMed Central PMCID: PMC7293591.

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Kestenbaum B, Gamboa J, Liu S, Ali AS, Shankland E, Jue T, Giulivi C, Smith LR, Himmelfarb J, de Boer IH, Conley K, Roshanravan B. Impaired skeletal muscle mitochondrial bioenergetics and physical performance in chronic kidney disease. JCI Insight. 2020 Mar 12;5(5). doi: 10.1172/jci.insight.133289. PubMed PMID: 32161192; PubMed Central PMCID: PMC7141399.

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Smith LR, Pichika R, Meza RC, Gillies AR, Baliki MN, Chambers HG, Lieber RL. Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy. Connect Tissue Res. 2019 Nov 28;:1-12. doi: 10.1080/03008207.2019.1694011. [Epub ahead of print] PubMed PMID: 31779492; PubMed Central PMCID: PMC7253322.

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Barton ER, Pham J, Brisson BK, Park S, Smith LR, Liu M, Tian Z, Hammers DW, Vassilakos G, Sweeney HL. Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. Muscle Nerve. 2019 Oct;60(4):464-473. doi: 10.1002/mus.26641. Epub 2019 Jul 30. PubMed PMID: 31323135; PubMed Central PMCID: PMC6771521.

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Xia Y, Pfeifer CR, Zhu K, Irianto J, Liu D, Pannell K, Chen EJ, Dooling LJ, Tobin MP, Wang M, Ivanovska IL, Smith LR, Greenberg RA, Discher DE. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019 Aug 5;218(8):2545-2563. doi: 10.1083/jcb.201811100. Epub 2019 Jun 25. PubMed PMID: 31239284; PubMed Central PMCID: PMC6683732.

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Smith LR, Irianto J, Xia Y, Pfeifer CR, Discher DE. Constricted migration modulates stem cell differentiation. Mol Biol Cell. 2019 Jul 22;30(16):1985-1999. doi: 10.1091/mbc.E19-02-0090. Epub 2019 Jun 12. PubMed PMID: 31188712; PubMed Central PMCID: PMC6727770.

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Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol. 2018 Nov 5;217(11):3796-3808. doi: 10.1083/jcb.201711161. Epub 2018 Aug 31. PubMed PMID: 30171044; PubMed Central PMCID: PMC6219729.

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Smith LR, Barton ER. Regulation of fibrosis in muscular dystrophy. Matrix Biol. 2018 Aug;68-69:602-615. doi: 10.1016/j.matbio.2018.01.014. Epub 2018 Feb 2. Review. PubMed PMID: 29408413; PubMed Central PMCID: PMC6519730.

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Ban E, Franklin JM, Nam S, Smith LR, Wang H, Wells RG, Chaudhuri O, Liphardt JT, Shenoy VB. Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. Biophys J. 2018 Jan 23;114(2):450-461. doi: 10.1016/j.bpj.2017.11.3739. PubMed PMID: 29401442; PubMed Central PMCID: PMC5984980.

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Smith LR, Cho S, Discher DE. Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics. Physiology (Bethesda). 2018 Jan 1;33(1):16-25. doi: 10.1152/physiol.00026.2017. Review. PubMed PMID: 29212889; PubMed Central PMCID: PMC5866410.

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Smith L, Cho S, Discher DE. Mechanosensing of matrix by stem cells: From matrix heterogeneity, contractility, and the nucleus in pore-migration to cardiogenesis and muscle stem cells in vivo. Semin Cell Dev Biol. 2017 Nov;71:84-98. doi: 10.1016/j.semcdb.2017.05.025. Epub 2017 Jun 3. Review. PubMed PMID: 28587976; PubMed Central PMCID: PMC5659905.

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Alvey CM, Spinler KR, Irianto J, Pfeifer CR, Hayes B, Xia Y, Cho S, Dingal PCPD, Hsu J, Smith L, Tewari M, Discher DE. SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors. Curr Biol. 2017 Jul 24;27(14):2065-2077.e6. doi: 10.1016/j.cub.2017.06.005. Epub 2017 Jun 29. PubMed PMID: 28669759; PubMed Central PMCID: PMC5846676.

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Discher DE, Smith L, Cho S, Colasurdo M, García AJ, Safran S. Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer. Annu Rev Biophys. 2017 May 22;46:295-315. doi: 10.1146/annurev-biophys-062215-011206. Review. PubMed PMID: 28532215; PubMed Central PMCID: PMC5444306.

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Smith LR, Hammers DW, Sweeney HL, Barton ER. Increased collagen cross-linking is a signature of dystrophin-deficient muscle. Muscle Nerve. 2016 Jun;54(1):71-8. doi: 10.1002/mus.24998. Epub 2016 Feb 22. PubMed PMID: 26616495; PubMed Central PMCID: PMC5067682.

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Philippou A, Minozzo FC, Spinazzola JM, Smith LR, Lei H, Rassier DE, Barton ER. Masticatory muscles of mouse do not undergo atrophy in space. FASEB J. 2015 Jul;29(7):2769-79. doi: 10.1096/fj.14-267336. Epub 2015 Mar 20. PubMed PMID: 25795455; PubMed Central PMCID: PMC4478801.

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Smith LR, Barton ER. SMASH - semi-automatic muscle analysis using segmentation of histology: a MATLAB application. Skelet Muscle. 2014;4:21. doi: 10.1186/2044-5040-4-21. eCollection 2014. PubMed PMID: 25937889; PubMed Central PMCID: PMC4417508.

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Ceco E, Bogdanovich S, Gardner B, Miller T, DeJesus A, Earley JU, Hadhazy M, Smith LR, Barton ER, Molkentin JD, McNally EM. Targeting latent TGFβ release in muscular dystrophy. Sci Transl Med. 2014 Oct 22;6(259):259ra144. doi: 10.1126/scitranslmed.3010018. PubMed PMID: 25338755; PubMed Central PMCID: PMC4337885.

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Smith LR. Influencing the secretion of myogenic factors from mesenchymal stem cells. Stem Cell Res Ther. 2014 Aug 13;5(4):96. doi: 10.1186/scrt485. PubMed PMID: 25157834; PubMed Central PMCID: PMC4282150.

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Smith LR, Barton ER. Collagen content does not alter the passive mechanical properties of fibrotic skeletal muscle in mdx mice. Am J Physiol Cell Physiol. 2014 May 15;306(10):C889-98. doi: 10.1152/ajpcell.00383.2013. Epub 2014 Mar 5. PubMed PMID: 24598364; PubMed Central PMCID: PMC4024713.

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Smith, Lucas R, Barton, Elisabeth R. SMASH - semi-automatic muscle analysis using segmentation of histology: a MATLAB application. 2014; doi: 10.6084/m9.figshare.1247634.

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Lei H, Leong D, Smith LR, Barton ER. Matrix metalloproteinase 13 is a new contributor to skeletal muscle regeneration and critical for myoblast migration. Am J Physiol Cell Physiol. 2013 Sep;305(5):C529-38. doi: 10.1152/ajpcell.00051.2013. Epub 2013 Jun 12. PubMed PMID: 23761625; PubMed Central PMCID: PMC3761151.

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Smith LR, Chambers HG, Lieber RL. Reduced satellite cell population may lead to contractures in children with cerebral palsy. Dev Med Child Neurol. 2013 Mar;55(3):264-70. doi: 10.1111/dmcn.12027. Epub 2012 Dec 5. PubMed PMID: 23210987; PubMed Central PMCID: PMC4054943.

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Smith LR, Lieber RL. Skeletal Muscle Changes due to Cerebral Palsy . In: Cerebral Palsy in Infancy. 1 ed. Shepherd RB, editor. Philadelphia, PA 19103: Elsevier Health Sciences; 2013. Chapter 6; p.135-156. 339p.

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Smith LR, Meyer G, Lieber RL. Systems analysis of biological networks in skeletal muscle function. Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb;5(1):55-71. doi: 10.1002/wsbm.1197. Epub 2012 Nov 27. Review. PubMed PMID: 23188744; PubMed Central PMCID: PMC4076960.

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Smith LR, Chambers HG, Subramaniam S, Lieber RL. Transcriptional abnormalities of hamstring muscle contractures in children with cerebral palsy. PLoS One. 2012;7(8):e40686. doi: 10.1371/journal.pone.0040686. Epub 2012 Aug 16. PubMed PMID: 22956992; PubMed Central PMCID: PMC3431909.

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Smith L, Fowler-Gerace L, Lieber R. Response to Letter to the Editor: ‘Poisson's ratios in anisotropic materials at finite strains; comment on short communication by Smith et al. (2011)’. Journal of Biomechanics. 2012 June; 45(10):1859-1860. doi: 10.1016/j.jbiomech.2012.01.044.

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Smith L, Fowler-Gerace L, Lieber R. Corrigendum to “Muscle extracellular matrix applies a transverse stress on fibers with axial strain” [J. Biomech. 44 (2011) 1618–1620]. Journal of Biomechanics. 2012 January; 45(1):207-. doi: 10.1016/j.jbiomech.2011.10.006.

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Gillies AR, Lieber RL. Structure and function of the skeletal muscle extracellular matrix. Muscle Nerve. 2011 Sep;44(3):318-31. doi: 10.1002/mus.22094. Review. PubMed PMID: 21949456; PubMed Central PMCID: PMC3177172.

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Smith LR, Fowler-Gerace LH, Lieber RL. Muscle extracellular matrix applies a transverse stress on fibers with axial strain. J Biomech. 2011 May 17;44(8):1618-20. doi: 10.1016/j.jbiomech.2011.03.009. Epub 2011 Mar 29. PubMed PMID: 21450292; PubMed Central PMCID: PMC3085660.

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Smith LR, Lee KS, Ward SR, Chambers HG, Lieber RL. Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length. J Physiol. 2011 May 15;589(Pt 10):2625-39. doi: 10.1113/jphysiol.2010.203364. Epub 2011 Mar 21. PubMed PMID: 21486759; PubMed Central PMCID: PMC3115830.

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Gillies AR, Smith LR, Lieber RL, Varghese S. Method for decellularizing skeletal muscle without detergents or proteolytic enzymes. Tissue Eng Part C Methods. 2011 Apr;17(4):383-9. doi: 10.1089/ten.TEC.2010.0438. Epub 2010 Dec 6. PubMed PMID: 20973753; PubMed Central PMCID: PMC3065727.

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Smith LR, Pontén E, Hedström Y, Ward SR, Chambers HG, Subramaniam S, Lieber RL. Novel transcriptional profile in wrist muscles from cerebral palsy patients. BMC Med Genomics. 2009 Jul 14;2:44. doi: 10.1186/1755-8794-2-44. PubMed PMID: 19602279; PubMed Central PMCID: PMC2722667.

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Smith L, Tainter C, Regnier M, Martyn DA. Cooperative cross-bridge activation of thin filaments contributes to the Frank-Starling mechanism in cardiac muscle. Biophys J. 2009 May 6;96(9):3692-702. doi: 10.1016/j.bpj.2009.02.018. PubMed PMID: 19413974; PubMed Central PMCID: PMC3325146.

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Martyn DA, Smith L, Kreutziger KL, Xu S, Yu LC, Regnier M. The effects of force inhibition by sodium vanadate on cross-bridge binding, force redevelopment, and Ca2+ activation in cardiac muscle. Biophys J. 2007 Jun 15;92(12):4379-90. doi: 10.1529/biophysj.106.096768. Epub 2007 Mar 30. PubMed PMID: 17400698; PubMed Central PMCID: PMC1877787.