Investigación

Las actividades de investigación, en nuestras palabras...

En nuestro grupo de investigación aplicamos los conocimientos de la química farmacéutica para la búsqueda y optimización de moléculas activas contra padecimientos crónico-degenerativos:

• Epilepsia

• Enfermedades autoinmunes

• Obesidad

• Hipertensión

Adicional a estas líneas principales, y dado a la experiencia inicial en química farmacéutica del fundador del grupo, también siguen activas las líneas de enfermedades parasitarias y cáncer. Asimismo, en estrecha colaboración con otros grupos de investigación, se tiene la línea de farmacología in silico de productos naturales.

Publicaciones científicas desde la fundación del grupo:

• Aguilera-Durán, G.; Hernández-Castro, S.; Loera-García, B.V.; Rivera-Vargas, A.; Alvarez-Baltazar, J.M.; Cuevas-Flores, M.R.; Romo-Mancillas, A. Ursolic acid interaction with transcription factors BRAF, V600E, and V600K: a computational approach towards new potential melanoma treatments. Journal of Molecular Modeling (2024) 30, 373. 

• Loera-García, B.V.; Leyva-Ramos, S.; Cardoso-Ortiz, J.; Noriega, S.; Romo-Mancillas, A.; Baines, K. M.; McOnei, S.L. An Alternative Method for the Selective Synthesis of Ortho-nitro Anilines Using Bismuth Nitrate Pentahydrate. Current Organic Synthesis (2024), 21, 1-9.

• Gonzalez-Llerena, J.L.; Espinosa-Rodriguez, B.A.; Treviño-Almaguer, D.; Mendez-Lopez, L.F.; Carranza-Rosales, P.; Gonzalez-Barranco, P.; Guzman-Delgado, N.E.; Romo-Mancillas, A.; Balderas-Renteria, I. Cordycepin Triphosphate as a Potential Modulator of Cellular Plasticity in Cancer via cAMP-Dependent Pathways: An In Silico Approach. International Journal of Molecular Sciences (2024), 25, 5692.

• Domínguez-Chavarría, J.A.; García, A.; Romo-Mancillas, A.; Reyes-Melo, K. Y.; Chávez-Villareal, K. G.; Vázquez-Ramírez, A.L.; Ávalos-Alanís, F.G.; Cabral-Romero, C.; Hernández-Delgadillo, R.;  García-Cuellar, C. M.; Camacho-Corona, M. R. Cytotoxicity Activity of Some meso-Dihydroguaiaretic Acid Derivatives and Mode of Action of the Most Active Compound. Chemitry & Biodiversity (2024), 21(2), e202301930.

• Ignacio-Mejía, I., Contreras-García, I.J., Mendoza-Torreblanca, J. G., Medina-Campos, O. N., Pedraza-Chaverri, P., García-Cruz, M. E., Romo-Mancillas, A., Gómez-Manzo, S., Bandala, C., Sánchez-Mendoza, M. E., Pichardo-Macías, L. A., Cárdenas-Rodríguez, N. Evaluation of the Antioxidant Activity of Levetiracetam in a Temporal Lobe Epilepsy Model. Biomedicines (2023) 11(3):848.

• Villegas-Ruíz, V., Romo-Mancillas, A., Medina-Vera, I., Castro-López, K. A., Ramirez-Chiquito, J. C., Fonseca-Montaño, M. A., García-Cruz, M. E., Rivera-Luna, R., Mendoza-Torreblanca, J. G., Juárez-Méndez, S. The Proliferating Cell Nuclear Antigen (PCNA) Transcript Variants as Potential Relapse Markers in B-Cell Acute Lymphoblastic Leukemia Cells (2022) 11(20): 3205.

• Huerta-García, C. S., Pérez, D. J., Velázquez-Martínez, C. A., Tabatabaei Dakhili, S. A., Romo-Mancillas, A., Castillo, R., Hernández-Campos, A. Structure–Activity Relationship of N-Phenylthieno[2,3-b]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring Pharmaceuticals (2022) 15(3): 283.

• Contreras-García, I.J.; Cárdenas-Rodríguez, N.; Romo-Mancillas, A.; Bandala, C.; Zamudio, S.R.; Gómez-Manzo, S.; Hernández-Ochoa, B.; Mendoza-Torreblanca, J.G.; Pichardo-Macías, L.A. Levetiracetam Mechanisms of Action: From Molecules to Systems. Pharmaceuticals (2022), 15, 475. 

• Betancourt-Conde, I., Avitia-Domínguez, C., Hernández-Campos, A., Castillo, R., Yépez-Mulia, L., Oria-Hernández, J., Méndez, S.T., Sierra-Campos, E., Valdez-Solana, M., Martínez-Caballero, S., Hermoso, J.A., Romo-Mancillas, A., Téllez-Valencia, A. Benzimidazole Derivatives as New and Selective Inhibitors of Arginase from Leishmania mexicana with Biological Activity against Promastigotes and Amastigotes. International Journal of Molecular Sciences (2021); 22(24):13613. 

• Valencia-Guzmán, C. J.; Castro-Ruiz, J. E.; García-Gasca, T.; Rojas-Molina, A.; Romo-Mancillas, A.; Luna-Vázquez, F. J.; Rojas-Molina, J. I.; Ibarra-Alvarado, C. Endothelial TRP channels and cannabinoid receptors are involved in affinin-induced vasodilation, Fitoterapia (2021);153,104985.

• Aguilera-Durán, G.; Romo-Mancillas, A. Behavior of Chemokine Receptor 6 (CXCR6) in Complex with CXCL16 Soluble form Chemokine by Molecular Dynamic Simulations: General Protein‒Ligand Interaction Model and 3D-QSAR Studies of Synthetic Antagonists. Life (2021); 11, 346.

• Stefani, T.; Romo-Mancillas, A.; Carrizales-Castillo, J.J.J.; Arredondo-Espinoza, E.; Ramírez-Estrada, K.; Alcantar-Rosales, V.M.; González-Maya, L.; Sánchez-Carranza, J.N.; Balderas-Renterías, I.; Camacho-Corona, M.d.R. Cytotoxic Fractions from Hechtia glomerata Extracts and p-Coumaric Acid as MAPK Inhibitors. Molecules (2021); 26, 1096.

• Nocedo-Mena, D.,  Arrasate, S., Garza-González, E., Rivas-Galindo, V. M., Romo-Mancillas, A., Munteanu, C. R., Sotomayor, N., Lete, E., Barbolla, I., Martín, C. A., Camacho-Corona, M. R. Molecular docking, SAR analysis and biophysical approaches in the study of the antibacterial activity of ceramides isolated from Cissus incisa. Bioorganic Chemistry (2021); 109, 104745. 

• Becerra, E.; Aguilera-Durán, G.; Berumen, L.; Romo-Mancillas, A.; García-Alcocer, G. Study of Endogen Substrates, Drug Substrates and Inhibitors Binding Conformations on MRP4 and Its Variants by Molecular Docking and Molecular Dynamics. Molecules (2021); 26, 1051.

• Buitrón-González, I., Aguilera-Durán, G., Romo-Mancillas, A.  In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex. Results in Chemistry (2021); 3, 100094.

• Aguilera-Durán, G., Romo-Mancillas, A. Computational Study of C-X-C Chemokine Receptor (CXCR)3 Binding with Its Natural Agonists Chemokine (C-X-C Motif) Ligand (CXCL)9, 10 and 11 and with Synthetic Antagonists: Insights of Receptor Activation towards Drug Design for Vitiligo. Molecules (2020); 25(19), 4413.

• Rodríguez-Cruz, A., Romo-Mancillas, A., Mendiola-Precoma, J., Escobar-Cabrera, J.E., García-Alcocer, G., Berumen, L.C. Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson's disease. IBRO Reports (2020); 8: 28-35.

• Gutiérrez-Gutiérrez, F., Romo-Mancillas, A., Puebla-Pérez, A.M., Hernández-Hernández, J.M., Castillo-Romero, A. Identification and molecular characterization of the tubulin-podophyllotoxin-type lignans binding site on Giardia lamblia. Chemical Biology and Drug Design (2019); 94 (6): 2031-2040.

• Medina-Ruiz, D., Erreguin-Luna, B., Luna-Vázquez, F., Romo-Mancillas, A., Rojas-Molina, A., Ibarra-Alvarado, C. Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H2S/KATP Pathways and Blockade of α1-Adrenoceptors and Calcium Channels. Molecules (2019); 24(5): 987.

• Romo-Mancillas, A., Lemus, R., Pérez-Estrada, R., Kuribreña-Romero de Terreros, F., Domínguez-Ramírez, L. Molecular dynamics simulations of the catalytic subunit of Calpains 1, 2, 5 and 10: structural analysis with an aim towards drug design. Chemical Biology and Drug Design (2018); 93(1): 38-49.

• Chávez-Villareal, K.G., García, A., Romo-Mancillas, A., Garza-González, E., Waskman de Torres, N., Miranda, L. D., Moo-Puc, R. E., Chale-Dzul, J., Camacho-Corona, M.R. Synthesis, antimycobacterial evaluation and QSAR analysis of meso-dihydroguaiaretic acid derivatives. Medicinal Chemistry Research (2018); 27, 1026-1042.

• Trejo-Soto, P.J., Hernández-Campos, A., Romo-Mancillas, A., Medina-Franco, J.L., Castillo, R. In search of AKT kinase inhibitors as anticancer agents: structure-based design, docking, and molecular dynamics studies of 2,4,6-trisubstituted pyridines. Journal of Biomolecular Structure and Dynamics (2018); 36: 423-442.

• Reyes-Melo, K., García, A., Romo-Mancillas, A., Garza-González, E., Rivas-Galindo, V.M., Miranda, L.D., Vargas-Villareal, J., Favela-Hernández, J.M., Camacho-Corona, M.R. meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity. Bioorganic & Medicinal Chemistry (2017); 25: 5247-5259.

• Santes-Palacios, R.; Romo-Mancillas, A.; Camacho-Carranza, R.; Espinoza-Aguierra, J. J. Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds Toxicology Lettlers (2016); 258:267-275.

• Luna-Vázquez, F.J.; Ibarra-Alvarado, C.; Rojas-Molina, A.; Romo-Mancillas, A.; López-Vallejo, F.H.; Solís-Gutiérrez, M.; Rojas-Molina, J.I.; Rivero-Cruz, F. Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits. Molecules (2016); 21:78-95.

• Correa-Basurto, J., Cuevas-Hernández, R., Phillips-Farfán, B., Martínez-Archundia, M., Romo-Mancillas, A., Ramírez-Salinas, G., Pérez-González, Ó., Trujillo-Ferrara, J., Mendoza-Torreblanca, J. Identification of the antiepileptic racetam binding site in the synaptic vesicle protein 2A by molecular dynamics and docking simulations. Frontiers in Cellular Neuroscience (2015); 9:1-12.