Throughout her scientific career, Salome was consistently subject to misogynistic behaviour. She believes this problem for females in science starts from childhood (Zuckerman et al 1991). Girls who are interested in science, are selected from childhood. They must grow up fighting for themselves and be very competitive. On the other hand, this is not determined in early childhood for males. Men have more opportunities within the scientific community and do not experience the same constraints based on their upbringing. During the completion of her PhD, is when Salome began to experience workplace sexism. This occurred in the hands of Hans Spemann, a regarded male chauvinist. For her dissertation, she was assigned simple boring projects, while male colleagues were given exciting problems to solve. This problem was not uncommon for women at the time. 

After receiving her PhD, Salome started her job hunt. Despite her years of education and training, her hunt was unsuccessful. During one interview Salome was told, “You a woman and a Jew- forget about it” (Gilbert 1997). Later on, after fleeing to America, Salome again struggled to find employment. She spent years as nothing more than a lab technician, a job she was overqualified for. However, in 1936 she began her work as a research associate for L.C. Dunn. During this time, she often felt repressed and deprived of a career (Zuckerman et al 1991). Despite 19 years of ground-breaking work and discoveries, Salome was rejected for a promotion to faculty member (Silvers 2008). As per Columbia policy, she was told that no women would even be considered for a faculty position in the science department at Columbia University. One of her colleagues Sally Hughes-Schrader, a non-Jew, also faced similar sexist policies and limitations while at Columbia (Zuckerman et al 1991). Despite these challenges in her career Salome remained optimistic. She was able to use these adversities to educate and encourage women to chase after their dreams and pursue science (Silvers 2008).