PUBLICATIONS

Recent publications:

58. Satou M, Wang J, Nakano-Tateno T, Teramachi M, Suzuki T, Hayashi K, Lamothe S, Hao Y, Kurata H, Sugimoto H, Chik C, Tateno T. 2020. L-type amino acid transporter 1, LAT1, in growth hormone-producing pituitary tumor cells. Mol Cell Endocrinol. Jun 21;515:110868. PMID: 32579901.

57. Li J, Maghera J, Lamothe SM, Marco EJ, H.T. Kurata. 2020. Heteromeric assembly of truncated neuronal Kv7 channels: implications for neurological disease and pharmacotherapy. Mol Pharmacol. Jun 24; PMID: 32580997.

56. Lamothe SM, H.T. Kurata. 2020 Slc7a5 alters Kvβ-mediated regulation of Kv1.2. J Gen Physiol. Jul 6;152(7). PMID: 32311044.

55. Kanyo R, Wang CK, Locskai LF, Li J, Allison WT, H.T. Kurata. 2020. Functional and behavioral signatures of Kv7 activator drug subtypes. Epilepsia. 2020 Jul 11; PMID: 32652600.

54. Yousuf MS, Samtleben S, Lamothe SM, Friedman TN, Catuneanu A, Thorburn K, Desai M, Tenorio G, Schenk GJ, Ballanyi K, Kurata HT, Simmen T, Kerr BJ. 2020. Endoplasmic reticulum stress in the dorsal root ganglia regulates large-conductance potassium channels and contributes to pain in a model of multiple sclerosis. FASEB J. Jul 17; PMID: 32677089.

53. H.T. Kurata. 2020. Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action. J Gen Physiol. 2020 Aug 3;152(8). PMID: 32484852.

52. Yousuf MS, Noh MC, Friedman TN, Zubkow K, Johnson JC, Tenorio G, Kurata HT, Smith PA, Kerr BJ. 2019. Sensory Neurons of the Dorsal Root Ganglia Become Hyperexcitable in a T-Cell-Mediated MOG-EAE Model of Multiple Sclerosis. eNeuro. Apr. 1 6(2). PMID: 30957012.

51. Baronas, V.A.,Yang, R.Y., Morales, L.C., Sipione, S., and H.T. Kurata. 2018. Slc7a5 regulators Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications. 9(1):4417. PMID: 30356053.

50. Wang,C.K., Wang,A.W., Yang,R.Y., H.T. Kurata. 2018.State-dependent actions of pore and voltage sensor targeted KCNQ openers. J. Gen Physiol. 150(12):1722-1734. PMID: 30373787.

49. Yau, M.C., Kim, R.Y., Wang,C.K., Li, J., Ammar, T.E., Yang,R.Y., Pless, S.A., H.T. Kurata. 2018. One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels. J. Gen Physiol. 150(10):1421-1431. PMID: 30166314.

48. Wang,A.W., Yau, M.C., Wang,C.K., Sharmin,N., Yang,R.Y., Pless, S.A., H.T. Kurata. 2018. Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener. J. Gen Physiol. 150(10):1432-1443. PMID: 30166313.

47. Macdonald, L.C., Kim, R.Y., Kurata, H.T., Fedida, D. 2018. Probing the molecular basis of hERG drug block with unnatural amino acids. Sci. Rep. 8(1): 289. PMID: 29321549

46. Kim R.Y.,and H.T. Kurata. 2018. Site-Directed Unnatural Amino Acid Mutagenesis to Investigate Potassium Channel Pharmacology in Xenopus laevis Oocytes. Methods Mol. Biol.1684: 253-263. PMID: 29058197

45. Kim, R.Y., Pless, S.A., and H.T. Kurata. 2017. PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels. PNAS. 114(45):E9702- E9711. PMID: 29078287

44. Baronas, V.A., Yang, R.Y., and H.T. Kurata. 2017. Extracellular redox sensitivity of Kv1.2 potassium channels. Sci. Rep. 7(1):9142. PMID: 28831076

43. Wrobel, E., Rothenberg, I., Krisp, C., Hundt, F., Fraenzel, B., Eckey, K., Linders, J.T., Gallacher, D.J., Towart, R., Pott, L., Pusch, M., Yang, T., Roden, D.M., Kurata, H.T., Schulze-Bahr, E., Strutz-Seebohm N., Wolters, D., and Seebohm, G. 2016. KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmalogical targeting. Nature Communications. 7:12795. PMID: 27731317.

42. H.T. Kurata. 2016. Emerging complexities of lipid regulation of potassium channels. J. Gen. Physiol. 148(3):201-5. PMID: 27574290.

41. Wang, A.W., Yang, R., and H.T. Kurata. 2016. Sequence determinants of subtype-specific actions of KCNQ channel openers. J. Physiol. Epub August 9, 2016. PMID: 27506413.

40. Baronas, V.A., Yang, R., Vilin, Y.Y., and H.T. Kurata. 2015. Determinants of frequency-dependent regulation of Kv1.2-containing potassium channels. Channels. Dec. 8:1-9. PMID: 26646078.

39. Kim, R.Y., Yau, M., Galpin, J.D., Ahern, C.A., Pless, S.A., and H.T. Kurata. 2015. Atomic basis for therapeutic activation of neuronal potassium channels. Nature Communications. 6:8116. PMID: 26333338.

38. Zhang, R.S., Wright, J., Pless, S.A., Nunez, J.J., Kim, R.Y., Li, J.B.W., Yang, R., Ahern, C.A., and H.T. Kurata. 2015. A conserved residue that governs kinetics of ATP-dependent gating of Kir6.2 potassium channels. J. Biol. Chem. 290(25):15450-61. PMID: 25934393.

37. Pless, S.A., Kim, R.Y., Ahern, C.A., and H.T. Kurata. 2015. Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology. J. Physiol. 593(12):2627-2634. PMID: 25640301.

36. Baronas, V., McGuinness, B.R., Brigidi, G.S., Gomm Kolisko, R.H., Vilin, Y.Y., Kim, R.Y., Lynn, F.C., Bamji, S.X., Yang, R.Y. and H.T. Kurata. 2015. Use-dependent activation of neuronal Kv1.2 channel complexes. J. Neurosci. 35(8):3515:3524. PMID: 25716850.

35. Harel, S., Cohen, A., Hussain, K., Flanagan, S., Schlade-Bartusiak, K., Li, J.B.W., Kurata, H.T., Ellard, S., Chanoine, J.P. and W.T. Gibson. 2015. Alternate hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H mutation of ABCC8: An unusual clinical picture. J Pediatr Endocrinol Metab. 28(3-4):345-351. PMID: 25720052.

34. Baronas, V., H.T. Kurata. 2014. Inward rectifiers and their regulation by endogenous polyamines. Review article in Frontiers in Physiology. 5:325. PMID: 25221519

33. Yang, Y.H.C., Vilin, Y.Y., Roberge, M., Kurata, H.T., and J.D. Johnson. 2014. Multi-parameter screening reveals a role for Na+ channels in cytokine-induced beta-cell death. Molecular Endocrinology. 28(3): 406-417. PMID: 24438339.

32. Bruin, J.E., Erener, S., Vela, J., Johnson, J.D., Hu, X., Kurata, H.T., Lynn, F.C., Piret, J.M, Rezania, A. and T.J. Kieffer. 2014. Modeling human fetal pancreas development in vitro using human embryonic stem cells. Stem Cell Research. 12(1):194-208. PMID: 24257076.

31. Pless, S.A., Galpin, J.D., Niciforovic, A.P, Kurata, H.T., and C.A. Ahern. 2013. Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels. ELife, 2(0):e01289. PMID: 24327560.

30. Pless, S.A., Elstone, F.A., Niciforovic, A.P., Galpin, J.D., Kurata, H.T., and C.A. Ahern. 2014. Functional contribution of acidic and aromatic side chains in sodium channel voltage-sensor domains. J. Gen. Physiol. 143(5):645-56. PMID: 24778431

29. Li, B.W., Huang, X., Zhang, R.S., Kim, R.Y., Yang, R., and H.T. Kurata. 2013. Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels. J. Biol. Chem., 288(32):23038-49. PMID: 23798684.

28. Vilin, Y.Y., Nunez, J.J., Kim, R.Y., and H.T. Kurata. 2013. Paradoxical activation of a Kir channel mutant by spermine: ‘(b)locking’ open the bundle crossing gate. Mol. Pharmacology, 84(4):572-81. PMID: 23887925.

27. Pless, S.A., Niciforovic, A.P., Galpin, J.D., Nunez, J.J., Kurata, H.T., and C.A. Ahern. 2013. A novel mechanism for regulating open state stability in a voltage-gated potassium channel. Nature Communications, 4:1784 PMID: 23653196.

26. Sala-Rabanal, M., Li, D.C., Dake, G.R., Kurata, H.T., Inyushin, M., Skatchkov, S.N., and C.G. Nichols. 2013. Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3. Mol. Pharm. 10(4):1450-8. PMID: 23458604.

25. Kurata H.T., Akrouh, A., Li, J.B.W., Marton, L.J., and C.G. Nichols. 2013. Scanning the topography of polyamine blocker binding in an inwardly-rectifying potassium channel. J. Biol. Chem. 288(9):6591-601. PMID: 23300089.

24. Ponce-Balbuena, D., Rodríguez-Menchaca, A.A., López-Izquierdo, A., Ferrer, T., Kurata, H.T., Nichols, C.G., and J.A. Sánchez-Chapula. 2012. Molecular mechanisms of the cardiac I_KATP (Kir6.2/SUR2A) channel inhibition by the antimalarial drug chloroquine. Mol. Pharmacology. 82(5):803-13. PMID: 22851715.

23. Khurana, A., Shao, E.S., Kim, R.Y., Vilin, Y.Y., Huang, X.,Yang., R.Y., and H.T. Kurata. 2011 Forced gating motions by a substituted titratable side chain in the bundle crossing of a potassium channel. J. Biol. Chem., 286(42):36686-93. PMID: 21878633.