Publications

Publications:

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1. Pederson JL, Padwal RS, Wagg A, Holroyd-Leduc JM, Wang X, Majumdar SR, Khadaroo RG. Delayed mobilization in elderly abdominal surgery patients and readmission or death after discharge. PLOSOne (submitted Jan 2020).
2. Salim SY, Al-Khathiri O, Tandon P, Baracos VE, Churchill TA, Warkentin LM, Khadaroo RG. Thigh ultrasound used to identify frail sarcopenic elderly surgical patients: A pilot study. Journal of Surgical Research (accepted with revisions Jan 2020).
3. Young PY, Mueller T, Banu S, Churchill TA, Khadaroo RG. Oncostatin M plays a critical role in survival following acute intestinal ischemia reperfusion injury. Surgical Infections Published Online: 05 May 2020 https://doi.org/10.1089/sur.2019.193.
4. Hofmeister M, Khadaroo RG, Holroyd-Leduc J, Padwal R, Wagg A, Warkentin L, Clement F. Cost-effectiveness Analysis of the Elder-friendly Approaches to the Surgical Environment (EASE) Intervention for Emergency Abdominal Surgical Care of Adults Aged 65 Years and Older. JAMA Network OPEN 2020 Apr 1;3(4):e202034. doi: 10.1001/jamanetworkopen.2020.2034.
5. Khadaroo RG, Warkentin LM, Wagg AS, Padwal RS, Clement F, Wang X, Buie W, Holroyd-Leduc J. Clinical effectiveness of the Elder-friendly Approaches to the Surgical Environment (EASE) initiative in Emergency General Surgery: a prospective cohort study. JAMA Surgery. Published online 12 Feb 2020. doi:10.1001/jamasurg.2019.6021.
6. Purdy K, Anderson D, Camicioli R, Khadaroo RG. Can osmotic demyelination syndrome be a complication of liver failure? eNeuologicalSci. Volume 18, March 2020. https://doi.org/10.1016/j.ensci.2020.100223.
7. Bhullar AS, Anoveros-Barrera A, Dunichand-Hoedl A, Martins K, Bigam D, Khadaroo RG, McMullen T, Bathe O, Putman CT, Clandinin MT, Baracos V, Mazurak VC. Lipid is heterogenously distributed in muscle and associates with low radiodensity in cancer patients. Journal of Cachexia, Sarcopenia and Muscle. E-pub ahead of print 27 Jan 2020. https://doi.org/10.1002/jcsm.12533.
8. Anoveros-Barrera A, Bhullar AS, Stretch C, Esfandiari N, Dunichand-Hoedl A, Martins KJB, Bigam D, Khadaroo RG, McMullen T, Bathe OF, Damaraju S, Skipworth RJ, Putman CT, Baracos VE, Mazurek VC. Clinical and biological characterization of skeletal muscle tissue biopsies of surgical cancer patients. Journal of Cachexia, Sarcopenia and Muscle. DOI: 10.1002/jcsm.12466 (E-pub 15 Jul 2019)
9. Noble RMN, Salim SY, Walker B, Khadaroo RG, Chiarella AB, Gragasin FS, Bourque SL. Survival of Staphylococcus epidermidis in Propofol and Intralipid in the Dead Space of Intravenous Injection Ports. Anesthesia and Analgesia. 129(1)e20-e22, Jul 2019.
10. Muscedere J, Kim P, Afilalo J, Balion C, Baracos V, Bowdish D, Cesari M, Erusalimsky J, Fülöp T, Heckman G, Howlett S, Khadaroo RG, Kirkland J, Rodriguez Mañas L, Marzetti E, Paré G, Raina P, Rockwood K, Sierra F, Sinclair A, Skappak C, Verschoor C, Walter S. Identifying biomarkers of frailty to support frailty risk assessment, diagnosis and prognosis, Proceedings of the Canadian Frailty Network Workshop, January 15, 2018. The Journal of Frailty and Aging, 2019; 8(3): 106-11.
11. Eamer G, Clement F, Holroyd-Leduc J, Wagg A, Padwal R, Khadaroo RG. Frailty predicts increased costs in emergent general surgery patients: A prospective cohort cost analysis. Surgery 2019 July; 166(1): 82-87
12. Saravana-Bawan B, Warkentin LM, Rucker D, Carr F, Churchill TA, Khadaroo RG. Incidence and Predictors of Post-operative Delirium in the Elderly Acute Care Surgery Population: A Prospective Study. Canadian Journal of Surgery 62(1):33-38, Feb 2019
13. Abdelrasoul GN, MacKay S, Salim SY, Ismond K, Tamura M, Khalifa C, Mannan E, Lin D, Mandal T, Montgomery R, Wishart D, Chen J, Khadaroo RG. Non-invasive point-of-care device to diagnose acute mesenteric ischemia. ACS Sensors. 3(11); 2296-2302, Nov. 2018.
14. Mueller K, Kokotilo MS, Carter J, Thiesen A, Madsen KL, Studzinski J, Khadaroo RG, Churchill TA. Creatine-loading preserves intestinal barrier function during organ preservation. Cryobiology. (84): 69-76, Oct. 2018
15. Eamer GJ, Al-Amoodi M, Holroyd-Leduc JM, Rolfson DB, Warkentin LM, Khadaroo RG. Review of Risk Assessment Tools to Predict Morbidity and Mortality in Elderly Surgical Patients. The American Journal of Surgery. 216(3) 585-594, Sept. 2018.
16. Macala K, Khadaroo RG, Panahi S, Gragasin FS, Bourque SL. Low dose intralipid resuscitation improves survival compared to ClinOleic in propranolol overdose in rats. PLoS One. 13(8) e-collection Aug 30 2018.
17. McComb A, Warkentin LM, McNeely M, Khadaroo RG. Development of a Reconditioning Program for Elderly Abdominal Surgery Patients: the Elder-friendly Approaches to the Surgical Environment - BEdside reconditioning for Functional ImprovemenTs (EASE-BE FIT) Pilot Study. World Journal of Emergency Surgery. 13:21 (E-collection), May 21 2018.
18. Pilieci S, Salim SY, Heffernan DS, Itani K, Khadaroo RG. A Randomized Controlled Trial of Video Education versus Skill Demonstration: Which is More Effective in Teaching Sterile Surgical Technique? Surgical Infections (Larchmt). 19(3):303-312, Apr. 2018.
19. Li Y, Pederson JL, Churchill TA, Wagg AS, Holroyd-Leduc JM, Alagiakrishnan K, Padwal RS, Khadaroo RG. Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study. CMAJ. 190(7):E184-E190, Feb 20 2018.
20. Eamer GJ, Clement F, Pederson JL, Church TA, Khadaroo RG. Analysis of Post-Discharge Costs Following Emergent General Surgery in the Elderly. Canadian Journal of Surgery. 61(1):19-27, Feb. 2018.
21. Eamer GJ, Taheri A, Chen SS, Daviduck Q, Chambers T, Shi X, Khadaroo RG. Comprehensive geriatric assessment for older people admitted to a surgical service. Cochrane Database Syst Rev. Jan 31 2018.
22. Eamer GJ, Gibson JA, Gillis C, Hsu AT, Krawczyk M, MacDonald E, Whitlock R, Khadaroo RG. Is current preoperative frailty assessment adequate? Canadian Journal of Surgery. 60(6):367-368, Dec. 2017.
23. Anderson D, Beecher G, Emery D, Khadaroo, RG. Teaching NeuroImages: Brain imaging findings in acute methanol toxicity. Neurology. 89(22):e264, Nov. 2017.
24. Eamer GJ, Saravana-Bawan B, Van Der Westhuizen B, Chambers T, Ohinmaa A, Khadaroo RG. Economic Evaluations of Comprehensive Geriatric Assessment in Surgical Patients: A Systematic Review. Journal of Surgical Research. Vol 218: 9-17, Oct. 2017.
25. Hanson H, Warkentin LM, Wilson R, Sandhu N, Slaughter S, Khadaroo RG. Facilitators and barriers of change toward an elder-friendly surgical environment: perspectives of clinician stakeholder groups. BMC Health Services Research. 17(1):596, Aug 24 2017.
26. Eamer GJ, Gibson JA, Gillis C, Hsu AT, Kraczyk M, MacDonald E, Whitlock R, Khadaroo RG. Surgical Frailty Assessment: A Missed Opportunity. BMC Anesthesiology. 17(1):99, July 2017.
27. Rochwerg B, Hylands M, Moller M, Asfar P, Cohen D, Khadaroo RG, Laake JH, Perner A, Tanguay T, Widder S, Vandvik P, Kristiansen A, Lamontagne F. CCCS-SSAI WikiRecs Clinical Practice Guideline: Vasopressor blood pressure targets in critically ill adults with hypotension. Canadian Journal Anaesthesia. 64(7): 763-765, July 2017.
28. Rochwerg B, Hylands M, Moller M, Asfar P, Cohen D, Khadaroo RG, Laake JH, Perner A, Tanguay T, Widder S, Vandvik P, Kristiansen A, Lamontagne F. CCCS-SSAI WikiRecs Clinical Practice Guideline: Vasopressors in early traumatic shock. Canadian Journal Anaesthesia. 64(7): 766-768, July 2017.
29. Rochwerg B, Hylands M, Moller M, Asfar P, Cohen D, Khadaroo RG, Laake JH, Perner A, Tanguay T, Widder S, Vandvik P, Kristiansen A, Lamontagne F. CCCS-SSAI WikiRecs Clinical Practice Guideline: Vasopressor blood pressure targets in critically ill adults with hypotension and vasopressor use in early traumatic shock. Intensive Care Medicine. 43 (7): 1062-64, July 2017.
30. Khadaroo RG, Salim SY, Tso V, Madsen KL, Lukowski CM, Churchill TA. Metabolomic profiling to characterize acute intestinal ischemia/reperfusion injury. PloSOne. 12 (6): ecollection, June 29 2017.
31. Alghamdi MH, Khadaroo RG, Fathimani K. Complicated sigmoid diverticulitis presenting as severe necrotizing soft tissue infection. Surgical Infections Case Reports. 2(1):14-16, 2017
32. Salim SY, Young PY, Li Y, Churchill TA, Khadaroo RG. Urine Intestinal Fatty Acid Binding Protein (I-FABP) Predicts Acute Mesenteric Ischemia in Patients. Journal of Surgical Research. 209: 258-265, Mar. 2017.
33. Eamer GJ, Taheri A, Chen SS, Daviduck Q, Chambers T, Shi X, Khadaroo RG. Comprehensive geriatric assessment for improving outcomes in elderly patients admitted to a surgical service. Cochrane Database of Systematic Reviews. Issue 1, 3 January 2017
34. Wilson R, Slaughter SE, Forbes D, Hanson H, Khadaroo RG. Experiences of a novice researcher conducting focus group interviews. International Journal of Nursing Student Scholarship, Vol. 3 (2016)
35. Pilieci S, Taheri A, Khadaroo RG. Occult Perforation at the Ligament of Treitz in a Patient with Cirrhosis: A Case Report and Literature Review. Surgical Infections Case Reports. 1(1): 88-92, 2016.
36. Leggett LE, Khadaroo RG, Holroyd-Leduc J, Lorenzetti DL, Hanson H, Wagg A, Padwal R, Clement F. Measuring resource utilization: A systematic review of validated self-reported questionnaires. Medicine. 95 (10): e2759, Mar. 2016.
37. Ali TF, Warkentin LM, Gazala S, Wagg, AS, Padwal RS, Khadaroo RG. Self-Reported Outcomes in Individuals Aged 65 and Older Admitted for Treatment to an Acute Care Surgical Service: A 6-Month Prospective Cohort Study. Journal of the American Geriatrics Society. 63(11): 2388-94, Nov. 2015.
38. Khadaroo RG, Padwal RS, Wagg AS, Clement F, Warkentin LM, Holroyd-Leduc J. Optimizing senior's surgical care - Elder-friendly Approaches to the Surgical Environment (EASE) Study: rationale and objectives. BMC Health Services Research. 15(1):338 21 Aug 2015 E-released.
39. Lees M, Merani S, Tauh K, Khadaroo RG. Perioperative Factors Predicting Poor Outcome in Elderly Patients Following Emergency General Surgery: A Multivariate Analysis. Canadian Journal of Surgery. 58(5): 312-7, Oct. 2015.
40. Beed M, Khadaroo RG, Singh G, Brindley PG. Chapter 11-Cardiothoracic: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 10(2): 6-19, 2015
41. Mapiour D, Brindley PG, Brisebois R, Khadaroo RG, Brindley PG. Chapter 10-Trauma: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 10(1): 6-17, 2015.
42. Kinnaird A, Fairey A, Rourke K, Khadaroo RG, Brindley PG. Chapter 9-Urology: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 9(4): 7, 2015.
43. Fortis S, Khadaroo RG, Haitsma J, Zhang H. Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis. Acta Anaesthesiologica Scandinavica. 59 (2): 170-5, Feb. 2015
44. Kupper S, Karvellas C, Khadaroo RG*, Widder S. Increased Health Services use by severely obese patients undergoing emergency surgery: A retrospective cohort study. Canadian Journal of Surgery. 58(1): 41-7, Feb. 2015.
45. Khadaroo RG*, Fortis S, Salim SY, Streutker C, Zhang H. I-FABP as a biomarker for acute mesenteric ischemia and resultant lung injury. Plos One. 9(12): 1-16, Dec. 2014.
46. Khadaroo RG, Shapiro JA, Brindley, PG. Chapter 8-Liver, Biliary System and Pancreatic: Surgical Insights for the Non-Surgeon. Canadian Journal of Gen Internal Medicine. 9(3):79-89, 2014.
47. Web Publication: Khadaroo RG. National Association of Biomedical Research (NABR) Liaison Report, Surgical Infection Society Meeting, Nov. 2014.
48. Khadaroo RG, Karvellas C, Brindley PG. Chapter 7-Liver and Portal venous: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 9(2): 45-51, 2014.
49. Du Y, Baracos VE, Karvellas CJ, Williams DC, Khadaroo RG. Sarcopenia is a Predictor of Outcomes in Very Elderly Patients Undergoing Emergency Surgery. Surgery. 156(3): 521-7, Sept. 2014.
50. Merani S, Payne J, Padwal R, Hudson D, Widder S, Khadaroo RG. Predictors of in-hospital mortality and complications in very elderly patients undergoing emergency surgery. World Journal of Emergency Surgery. 9(43), July 2014.
51. Mueller S, Brindley PG, Khadaroo RG. Chapter 6-Colon: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 9(1): 4-9, 2014.
52. Khadaroo RG, Fathimani K, Brindley PG. Chapter 5-Small Bowel: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 8(3):97-100, Oct. 2013.
53. Wong SK, Young PY, Widder S, Khadaroo RG. A descriptive survey study on the effect of age on quality of life following stoma surgery. Ostomy and Wound Management. 59(12): 16-23, 2013.
54. Salim SY, Young PY, Lukowski CM, Madsen KL, Churchill TA, Khadaroo RG. VSL#3 probiotics provide protection against acute intestinal ischemia/reperfusion injury. Beneficial Microbes. 4(4):357-65, Dec. 2013.
55. Lim D, Ozegovic D, Khadaroo RG*, Widder S. The Impact of an Acute Care Surgery Model with a Dedicated Daytime Operating Theatre on Outcomes and Timelines of Care in Patients with Biliary Tract Disease. World Journal of Surgery. 37(10): 2266-72, Oct. 2013.

56. Khadaroo RG, Fathimani K, Brindley PG. Chapter 4-Stomach: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 8(2):59-64, Aug. 2013.

57. Khadaroo RG, Williams DC, Brindley PG. Chapter 3-Head and Neck: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 8(2):53-57, Aug. 2013.

58. Brindley PG, Khadaroo RG, Sutherland D. Chapter 2-Tubes, Drains & Ostomies: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine. 8(1):21-25, Apr. 2013.

59. Brindley PG, Khadaroo RG, Sutherland D. Chapter 1-Introduction and Definitions: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine 8(1):16-18, Apr. 2013.

60. Gazala S, Tul Y, Wagg A, Widder S, Khadaroo RG. Quality of Life and long-term Outcomes of Octo- and Nonagenarians following Acute Care Surgery. World Journal of Emergency Surgery. 8(1):23, Jul. 2013

61. Dixon E, Cheadle WG, Khadaroo RG: Is chlorhexidine alcohol more effective than povidone iodine? Journal of the American College of Surgery. 214(3): 374-6, Mar. 2012.

62. Primrose M, McDermid RC, Tredget EE, Khadaroo RG: Orthostatic convulsive syncope in a burn patient. Journal of Burn Care & Research. 33(1):e14-6, Jan. 2012.

63. Dixon E, Cheadle WG, Khadaroo RG: Members of the Evidence-Based Reviews in Surgery Group: Preventing Postoperative Surgical Site Infection. Journal of the American College of Surgery. 212(3): 418-20, Mar. 2011.

64. Kokotilo MS, Schlachter K, Carter J, Thiesen A, Khadaroo RG, Churchill TA: Comparing the effects of Dextran 70 and Hydroxyethyl starch in an intestinal storage solution. Cryobiology. 61(3): 254-62, Dec. 2010.

65. Kokotilo MS, Carter J, Thiesen A, Chen MH, Ochs A, Khadaroo RG, Churchill TA: Optimizing the concentration of Hydroxethylstarch in a novel intestinal-specific preservation solution. Cryobiology. 61(3): 236-42, Dec. 2010.

66. Schlachter K, Kokotilo MS, Carter J, Thiesen A, Ochs A, Khadaroo RG, Churchill TA: Redefining the properties of an osmotic impermeant for intraluminal preservation solutions employed during cold storage of the intestine. World Journal of Gastroenterology. 7;16(45):5701-9, Dec 2010.

67. Khadaroo RG, Marshall JC: Gastrointestinal Dysfunction in the Critically Ill: Can We Measure It? Critical Care. 12: 180, Sept. 2008.

68. Powers, KA, Szaszi K, Khadaroo RG, Tawadros PS, Marshall JC, Kapus A, Rotstein OD: Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages. J Exp Med. 203(8): 1951-61, Aug. 2006.

69. Powers KA, Zurawska J, Szasi K, Khadaroo RG, Kapus Z, Rostein OD: Hypertonic resuscitation of hemorrhagic shock prevents alveolar macrophage activation by preventing systemic oxidative stress due to gut ischemia/reperfusion. Surgery. 137(1):66-74, Jan. 2005.

70. Khadaroo RG, He R, Parodo J, Powers KA, Kapus Z, Rotstein OD: The role of the Src family of tyrosine kinases following oxidant induced lung injury in vivo. Surgery 136(2):483-8, Aug. 2004.

71. Khadaroo RG, Fan J, Powers KA, Kapus A, Rotstein OD: Impaired Induction of IL-10 Expression in the Lung Folowing Hemorrhagic Shock. Shock 22(4):333-9, Oct. 2004.

72. Oreopoulos G, Wu H, Szaszi K, Fan J, Marshall JC, Khadaroo RG, He R, Kapus A, Rotstein OD: Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion: A role for interleukin-10. Hepatology 40(1):211-20, Jul. 2004.

73. Khadaroo RG, Kapus A, Powers KA, Cybulsky MI, Marshall JC, Rotstein OD: Oxidative stress reprograms LPS signaling via Src kinase-dependent pathway in Raw 264.7 macrophage cell line. J Biol Chem. 278(48):47834-41, Nov. 2003.

74. Powers KA, Kapus Z, Khadaroo RG, He R, Lindsay T, Rotstein OD: 25% Albumin prevents lung injury following shock/resuscitation. Critical Care Medicine 31(9): 2355-63, Sep. 2003.

75. Khadaroo RG, Parodo J, Powers KA, Papia G, Marshall JC, Kapus A, Rotstein OD: Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through a Src dependent pathway. Surgery. 134:212-46, Aug.2003.

76. Powers KA, Woo J, Khadaroo RG, Papia G, Kapus Z, Rotstein OD: Hypertonic resuscitation of hemorrhagic shock upregulates the anti-inflammatory response by alveolar macrophages. Surgery. 134:312-8, Aug. 2003.

77. Chan CW, Kay LS, Khadaroo RG, Chan MW, Lakatoo S, Young KJ, Zhang L, Gorczynski RM, Cattral M, Rotstein O, Levy GA. Soluble fibrinogen-like protein 2/fibroleukin exhibits immunosuppressive properties: suppressing T cell proliferation and inhibiting maturation of bone marrow-derived dendritic cells. Journal of Immunology. 170(8): 4036-44, Apr. 2003.

78. Khadaroo RG, Rotstein OD: Are clinician scientists an endangered species: Barriers to Clinician Scientist Training. Clinical Investigative Medicine. 25(6):260-61, Dec. 2002.

79. Khadaroo RG, Kneteman N, Joy S, Nguyen GK: Macrocystic serous adenoma of the pancreas: Pathology Research and Practice. 198(7):485-88, 2002.

80. Khadaroo RG, Lu Z, Powers KA, Papia G, Kapus Z, Rotstein OD: Impaired activation of mitogen activated protein kinases after hemorrhagic shock. Surgery. 132(2):360-64, Aug. 2002.

81. Powers KA, Kapus Z, Khadaroo RG, Papia G, Rotstein OD: 25% Albumin modulates adhesive interaction between neutrophils and the endothelium following shock/resuscitation. Surgery. 132(2):391-398, Aug. 2002.

82. Khadaroo RG, Marshall JC: ARDS and the Multiple Organ Dysfunction Syndrome. Common mechanisms of a common systemic process. Critical Care Clinics. 18(1):127-41, Jan. 2002.

83. Oreopoulos GD, Bradwell S, Lu Z, Fan J, Khadaroo RG, Marshall JC, Hua Y, Rotstein OD: Synergistic induction of IL-10 by hypertonic saline solution and lipopolysaccharides in murine peritoneal macrophages. Surgery. 130:157-65, Aug. 2001.

84. Khadaroo RG, Evans MG, Honore LH, Bhargava R, Phillipos E: Fetus-in-fetu presenting as cystic meconium peritonitis. The Journal of Pediatric Surgery. 35(5): 721-23, May 2000.

85. Thoma A, Khadaroo RG, Grigenas O, Archibald S, Jackson S, Young JE, Veltri K: Oromandibular reconstruction with the radial-forearm osteocutaneous flap: Experience with 60 consecutive cases. Plastic and Reconstructive Surgery. 104(2):368-78, Aug. 1999.

86. Khadaroo RG, Walton JM, Ramsay JA, Hicks MJ, Archibald SD: A mucoepidermoid carcinoma of the parotid gland: A rare presentation in a young child. The Journal of Pediatric Surgery. 33(6):893-95, June. 1998.

Submitted Refereed Papers

1. Eamer GJ, Holroyd-Leduc J, Wagg A, Padwal R, Khadaroo RG. Frailty Predicts Increased Costs in Emergent General Surgery Patients: A Prospective Cohort Cost Analysis Canadian Journal of Surgery (submitted).
2. Pederson JL, Padwal RS, Warkentin LM, Holroyd-Leduc JM, Wagg A, Khadaroo RG. Delayed mobilization following emergency abdominal surgery in elderly patients and outcomes after discharge: A prospective cohort study. Annals of Surgery Journal (submitted).
3. Bergman S, Khadaroo RG, Johnson P, Holroyd-Leduc J. What is the optimal preoperative assessment for elderly surgical patients? Canadian Journal of Surgery 2017.

Book Chapters:

1. Young PY, Khadaroo RG: Surgical Site Infections. Surgical Clinics of North America, (Sawyer & Hedrick), 94:1245–1264, 2014.
2. Khadaroo RG, Marshall JC: What Is The Role Of Source Control In Sepsis? Evidence-Based Practice of Critical Care (Deutschman CS and Neligan PJ). Saunders, Chapter 33, pp. 218-226. 2010.
3. Khadaroo RG, Nathens AB, Rotstein OD: Intraabdominal Abscesses. Infectious Diseases in Medicine and Surgery 3rd Edition (Gorbach SL, Bartlett JG, and Blacklow NR, eds). Acad. Press, Philadelphia PA 2004

Published Abstracts:

1. Ali G, Dunichand-Hoedl A, Salim SY, Mazurak VC, Baracos VE, Khadaroo RG. Paradoxical relationship of muscle fibre cross-sectional area in older emergency surgery patients. Highlights of the Canadian Frailty Network (CFN) Highly Qualified Personnel Poster Session. Canadian Geriatrics Journal Vol 22 (2), 2019.
2. Alghamdi M, Baracos VE, Karvellas T, Churchill TA, Khadaroo RG. The role of body composition in predicting outcomes in the elderly following acute abdominal surgery. Highlights of the Canadian Frailty Network (CFN) Highly Qualified Personnel Poster Session. Canadian Geriatrics Journal Vol 22 (2), 2019.
3. Ali G, Anoveros-Barrera A, Dunichand-Hoedl A, Khadaroo RG, Mazurak VC, Baracos VE. Skeletal muscle radiodensity and cross-sectional area predicts functional outcomes in elderly patients undergoing emergency surgery. Highlights of the Canadian Frailty Network (CFN) Highly Qualified Personnel Poster Session. Canadian Geriatrics Journal Vol 22 (2), 2019.
4. Macala KF, Khadaroo, RG, Panahi S, Gragasin FS, Bourque S. Cinaciguat Confers a Survival Advantage in Sepsis in Young and Aged Mice. Anesthesiology Annual Meeting, October 2017
5. Eamer GJ, Brisebois R, Clement F, Khadaroo RG. Surgical costs increase with age in emergency but not elective general surgery. Canadian Journal of Surgery 60:4 (Suppl 1) S131, August 2017
6. Pederson JL, Padwal RS, Wagg A, Holroyd-Leduc JM, Wang X, Majumdar SR, Khadaroo RG. Delayed mobilization and length of stay in elderly surgical patients: prospective cohort study. 21st IAGG World Congress of Gerontology and Geriatrics, San Francisco, CA, July 23-27, 2017
7. Pederson JL, Padwal RS, Warkentin L, Holroyd-Leduc JM, Wagg A, Khadaroo RG. Late mobilization in elderly surgical patients predicts readmission or death after discharge. Innovative Aging 2017 June 30; 1 (Suppl 1): 4.
8. Eamer GJ, Saravana-Bawan B, Van Der Westhuizen B, Chambers T, Ohinmaa A, Khadaroo RG. Economic Evaluations of Comprehensive Geriatric Assessment in Surgical Patients: A Systematic Review. Academic Surgical Congress, 15.10, February 2017
9. Eamer GJ, Taheri A, Chen SS, Daviduck Q, Chambers T, Khadaroo RG. Comprehensive Geriatric Assessment Improves Surgical Outcomes: A Systematic Review and Meta-analysis. Academic Surgical Congress, 73.08, February 2017
10. Li Y, Pederson JL, Churchill TA, Wagg AS, Holroyd-Leduc JS, Alagiakrishnan K, Padwal RS, Khadaroo RG. Pre-Admission Frailty Predicts Post-Discharge Adverse Events in Acute Care Surgery Patients. Academic Surgical Congress, 52.12, February 2017
11. McComb A, Daviduck Q, Eamer GJ, Warkentin L, Churchill TA, McNeely M, Khadaroo RG. Characterizing postoperative function in frail emergency abdominal surgery patients. Journal of the American College of Surgeons, 223 (4): e18, October 2016.
12. Macala KF, Khadaroo RG, Panahi S, Gragasin FS, Bourque SL. Intralipid Resuscitation Confers Survival Advantage Compared to ClinOleic in Rats Overdosed with Propranolol. American Society of Anaesthesiologists, Oct 2016.
13. Eamer GJ, Clement F, Pederson JL, Churchill TA, Khadaroo RG. Readmission is the greatest burden on post-discharge cost to the elderly following emergency general surgery, Canadian Journal of Surgery 59 (4 Suppl 1) S92, Aug 2016.
14. Eamer GJ, Clement F, Pederson JL, Churchill TA, Khadaroo RG. Readmission is the greatest burden on post-discharge cost to the elderly following emergency general surgery, Journal of the American College of Surgeons 223: 4(Suppl 1) S59-60, 2016.
15. McComb A, McNeely M, Khadaroo RG. Elder-friendly Approaches to the Surgical Environment: Bedside Reconditioning For Functional Improvements. Medicine and Science in Sports and Exercise. 48(5 Suppl 1):68, May 2016
16. Eamer GJ, Warkentin LM, Churchill TA, Clement F, Khadaroo RG. Post-Operative Costs to the Elderly Following Emergency Surgery; a Prospective Cost Analysis. Academic Surgical Congress, http://www.asc-abstracts.org/ #65.14, Feb 2016.
17. Alkathiri O, Salim SY, Warkentin LM, Gallivan A, Tandon P, Churchill TA, Baracos VE, Khadaroo RG. Ultrasound of Thigh Muscle Can Predict Frailty in Elderly Patients but Not Sarcopenia. Journal of Surgical Research, Academic Surgical Congress, http://www.asc-abstracts.org/ #11.16, Feb 2016.
18. Salim SY, Young PY, Li Y, Churchill TA, Khadaroo RG. Urine Intestinal Fatty Acid Binding Protein (I-FABP) Predicts Acute Mesenteric Ischemia in Patients. Journal of Surgical Research, Academic Surgical Congress, http://www.asc-abstracts.org/ #46.06, Feb 2016.
19. AlMalki N, Salim SY, Emberg M, Churchill TA, Khadaroo RG. OSMR Deficiency Provides Protection in Sepsis-Induced Morbidity & Mortality in both Young and Adult Mice. American College of Surgeons, 221 (4) e8, Oct 2015.
20. Alkathiri O, Salim SY, Warkentin L, Churchill TA, Tandon P, Khadaroo RG. Ultrasound Diagnosis of Sarcopenia is Predictive of Post-Operative Complications. American College of Surgeons, 221 (4) e18, Oct 2015.
21. Macala KF, Khadaroo RG, Panahi S, Gragasin FS, Bourque SL. Intralipid Resuscitation Confers Survival Advantage Compared to ClinOleic in Rats Overdosed with Propranolol. Critical Care Canada Forum, ePoster library, Oct 2015.
22. AlMalki N, Salim SY, Churchill TA, Khadaroo RG. Deficiency in Oncostatin M Receptor Results in Improved Survival in Older Mice Following Sepsis Through Down-Regulation of IL-10. Surgical Infections, 16 (S1), S-10, Apr 2015.
23. Salim SY, AlMalki N, Khadaroo RG, Churchill T. Oncostatin M Receptor Deficiency Results in Attenuated Peritoneal Inflammatory response enhanced survival in a murine sepsis model. Surgical Infections, 16 (S1), S-26, Apr 2015.
24. Salim SY, AlMalki N, Churchill TA, Khadaroo RG. Oncostatin M Receptor Deficiency Protects Against Sepsis in Older Mice. Academic Surgical Congress, #61.16, 72, Feb 2015.
25. Warkentin LM, Ali TF, Gazala S, Wagg A, Padwal R, Khadaroo RG. Change in Functional Status and Quality of Life in Elders Admitted to an Acute Care Surgery Service. Academic Surgical Congress, #64.19 75, Feb 2015.
26. Pedrycz B, Young PY, Compston CA, Luyckx V, Ho J, Mas V, Zhu LF, Grynoch D, Khadaroo RG, Mueller TF. Oncostatin M receptor is a sensitive and early marker of kidney injury. Swiss Medical Weekly. 144 (Suppl. 208): 20S, Nov. 2014.
27. Khadaroo RG, Young PY, Mian QN, Young JC, Compston CA, Mueller, TF. Oncostatin M Primes Macrophages for an Enhanced Pro-Inflammatory Response. American College of Surgeons, 219 3S: S42, Sept 2014.
28. Young PY, Salim SY, Compston CA, Mueller TF, Khadaroo RG. Oncostatin M modulates early inflammatory responses in a fluid resuscitated model of sepsis. Canadian Journal of Surgery. 57 (4 Suppl. 1): S115, Aug. 2014
29. Young PY, Salim SY, Compston CA, Mueller TF, Khadaroo RG. Oncostatin M modulates immune cell recruitment and bacterial translocation in a murine model of sepsis. Surgical Infections. 15(Suppl 1): S16, Apr 2014.
30. Young PY, Mueller TF, Luyckx VA, Compston CA, Churchill TA, Khadaroo RG. Oncostatin M modulates the inflammatory response in intestinal ischemia reperfusion injury. Journal of Surgical Research. 186 (2): 510, Feb 2014.
31. Du Y, Baracos VE, Karvellas CJ, Williams DC, Khadaroo RG. Sarcopenia is a Predictor of Outcomes in Very Elderly Patients Undergoing Emergency Surgery. Journal of Surgical Research. 186(2): 675, Feb 2014.
32. Lees M, Merani S, Tauh K, Khadaroo RG. Perioperative Factors Predicting Poor Outcome in Elderly Patients Following Emergency General Surgery: A Multivariate Analysis Study. Journal of Surgical Research. 186(2): 687, Feb 2014.
33. Young PY, Mian QN, Compston CA, Mueller TF, Khadaroo RG. The Role of Oncostatin M in macrophage activation. Canadian Journal of Surgery. 56 (4 Suppl. 3): S83, Aug. 2013
34. Young PY, Mian QN, Compston CA, Mueller TF, Khadaroo RG. Oncostatin M primes macrophage-epithelial cell interactions to lipopolysaccharide. Surgical Infections. 14 (Suppl 1): S11, Apr 2013.
35. Powers KA, Szaszi K, Khadaroo RG, Tawadros P, Marshall JC, Kapus A, Rotstein O. Hemorrhagic shock recruits, Toll-like receptor 4 to the plasma membrane in macrophages: A novel mechanism of cell priming for LPS signaling. Journal of the American College of Surgeons, 215 (5), 270, Nov 12.
36. Young PY, Mueller TF, Lucykx VA, Lukowski CM, Compston CA, Churchill TA, Khadaroo RG. Oncostatin M receptor deficiency results in increased mortality in an intestinal ischemia reperfusion model in mice. Canadian Journal of Surgery. 55 (4Suppl 1) Aug. 2012.
37. Payne JRM, Widder S, Tul Y, Primrose M, Hudson D, Khadaroo RG. Acute surgical outcomes in the 80 plus population. Canadian Journal of Surgery. 55(4 Suppl.1) Aug. 2012.
38. Merani S, Switzer N, Tul Y, Khadaroo RG, Widder S. Predicting discharge of elderly patients to prehospitalization residence following emergency general surgery. Canadian Journal of Surgery. 55(4 Suppl.1) Aug. 2012.
39. Young PY, Pedrycz B, Lucykx VA, Compston CA, Lukowski CM, Mueller TF, Khadaroo RG. Oncostatin M receptor deficiency provides a survival advantage in a septic shock model. Surgical Infections. 13 (Suppl 1): S12, Apr. 2012.
40. Young PY, Groeneveld A, Chan P, Smith S, Khadaroo RG: Risk factors for surgical site infections following colon surgery: a retrospective chart review. Canadian Journal of Surgery. 54 (Suppl): S17, Aug. 11.
41. Khadaroo RG, Lukowski CM, Churchill TA, Fedorak RN, Madsen KL: Metabolomic profiling to characterize acute intestinal ischemia/reperfusion injury. Surgical Infections. 12 (S1): S-32, Apr. 11
42. Khadaroo RG, Fortis S, Streutker C, Zhang H. Ileal fatty acid binding protein (I-FABP) a novel biomarker for acute intestinal ischemia and resultant lung injury. Surgical infections, 11 (2): 220, Apr 10.
43. Powers KA, Fan B, Szaszi K, Khadaroo RG, Kapus A, Rotstein OD: Stilbazulenyl nitrone (STAZN), a novel azulenyl nitrone antioxidant prevents lung injury following hemorrhagic shock and alters TLR4 distribution in alveolar macrophages. Journal of the American College of Surgeons, 199 (3) 40, Sept 2004.
44. Khadaroo RG, He R, Powers KA, Marshall JC, Kapus A, Rotstein OD: Altered LPS signaling in triple Src knock-out mice following oxidant stress. Surgical Infection, 5(1):90, spring 04
45. Powers KA, Khadaroo RG, Szaszi K, Kapus A, Rotstein OD: Oxidant stress induces Src kinase dependent upregulation of surface toll like receptor 4 (TLR4) expression on RAW 264.7 macrophages. Surgical Infection, 5(1):95, spring 04
46. Khadaroo RG, Parodo J, Powers KA, Papia G, Kapus A, Rotstein: The involvement of phosphatidylinositol 3-kinase (PI3-K)/Akt pathway in oxidative-induced reprogramming of LPS signaling. Clinical & Investigative Medicine, Aug 03
47. Khadaroo RG, Powers KA, Kapus A, Rotstein OD: Oxidant-induced priming of the macrophage involves activation of phosphatidylinositol 3-kinase (PI3-K) AND p38 through a Src dependent pathway. Surgical Infection, 4(1):89, spring 03
48. Khadaroo RG, Lu Z, Kapus A, Powers KA, Papia G, Rotstein OD: Oxidant stress reprograms LPS-induced NF-kB translocation to signal via Src kinases. Journal of the American College of Surgeons, 195(3):S83, 2002
49. Khadaroo RG, Lu Z, Kapus A, Powers KA, Papia G, Rotstein OD: The role of Src kinases in oxidant-induced priming of macrophages. Surgical Infection, 3(1):74, spring 02
50. Powers KA, Kapus A, Khadaroo RG, Papia G, Rotstein OD: Oxidants alter toll-like receptor 4 (TLR4) expression during shock/resuscitation. Surgical Infection, 3(1):89, spring 02
51. Papia G, Fan J, He R, Powers KA, Khadaroo RG, Kapus A, Rotstein OD: IL-10 treatment reverses failed upregulation of LPS-induced I-kappa B alpha mRNA following shock/resuscitation in alveolar macrophages. Surgical Infection, 3(1):70, spring 02
52. Khadaroo RG, Rotstein OD, Marshall JC: Neutralizing TNF in the treatment of sepsis and septic shock: A meta-analysis. Critical Care Medicine, 29(suppl. 12):A19, Dec.01
53. Khadaroo RG, Fan J, Lu Z, Powers K, Rotstein OD: Hemorrhagic shock fails to upregulate counterinflammatory cytokine IL-10. Clinical & Investigative Medicine, vol. 24, Aug. 01
54. Khadaroo RG, Lu Z, Fan J, Powers K, Rotstein OD: Xanthine oxidase-induced oxidative stress primes macrophages for increased LPS responsiveness. Surgical Infection, 2(1):84, spring 01
55. Powers K, Fan J, Kapus A, Khadaroo RG, Rotstein OD: 25% albumin prevents lung injury in a resuscitated shock animal model. Surgical Infection, 2(1): 77, spring 01
56. Khadaroo RG, Thoma A, Grigenas O: Mandible reconstruction with the free radial forearm osteocutaneous flap: 60 consecutive cases. The Canadian Journal of Plastic Surgery, 5(2):135, 97
57. Grigenas O, Thoma A, Khadaroo RG, Veltri K: Mandibular reconstruction using the radial forearm and fibular flap. Is it safe in elderly patients? The Canadian Journal of Plastic Surgery, 5(1):53, 97