Select Publications

• 1. Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential. Strachan E, Clemente-Casares X, Tsai S. Front Immunol. 2023 Mar 22;14:1146082. doi: 10.3389/fimmu.2023.1146082. eCollection 2023.

  2. Mechanosensing in macrophages and dendritic cells in steady-state and disease. Lee M, Du H, Winer DA, Clemente-Casares X, Tsai S. Front Cell Dev Biol. 2022 Nov 17;10:1044729. doi: 10.3389/fcell.2022.1044729. eCollection 2022.

  3. SARS-CoV-2 infection downregulates myocardial ACE2 and potentiates cardiac inflammation in humans and hamsters. Viveiros A, Noyce RS, Gheblawi M, Colombo D, Bilawchuk LM, Clemente-Casares X, Marchant DJ, Kassiri Z, Del Nonno F, Evans DH, Oudit GY. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1262-H1269. doi: 10.1152/ajpheart.00578.2022. Epub 2022 Nov 11.

  4. Novel lipid emulsion for total parenteral nutrition based on 18-carbon n-3 fatty acids elicits a superior immunometabolic phenotype in a murine model compared with standard lipid emulsions. Lucchinetti E, Lou PH, Holtzhauer G, Noureddine N, Wawrzyniak P, Hartling I, Lee M, Strachan E, Clemente-Casares X, Tsai S, Rogler G, Krämer SD, Hersberger M, Zaugg M. Am J Clin Nutr. 2022 Dec 19;116(6):1805-1819. doi: 10.1093/ajcn/nqac272.

  5. PDMS hydrogel-coated tissue culture plates for studying the impact of substrate stiffness on dendritic cell function. Lee M, Chu K, Chakraborty M, Kotoulas N, Akbari M, Goh C, Clemente-Casares X, Winer DA, Shrestha A, Tsai S. STAR Protoc. 2022 Mar 17;3(2):101233. doi: 10.1016/j.xpro.2022.101233. eCollection 2022 Jun 17. 

  6. Mechanical Stiffness Controls Dendritic Cell Metabolism and Function. Chakraborty M, Chu K, Shrestha A, Revelo XS, Zhang X, Gold MJ, Khan S, Lee M, Huang C, Akbari M, Barrow F, Chan YT, Lei H, Kotoulas NK, Jovel J, Pastrello C, Kotlyar M, Goh C, Michelakis E, Clemente-Casares X, Ohashi PS, Engleman EG, Winer S, Jurisica I, Tsai S, Winer DA. Cell Rep. 2021 Jan 12;34(2):108609. doi: 10.1016/j.celrep.2020.108609. 

  7. Gut-associated IgA+ immune cells regulate obesity-related insulin resistance. Luck H, Khan S, Kim JH, Copeland JK, Revelo XS, Tsai S, Chakraborty M, Cheng K, Tao Chan Y, Nøhr MK, Clemente-Casares X, Perry MC, Ghazarian M, Lei H, Lin YH, Coburn B, Okrainec A, Jackson T, Poutanen S, Gaisano H, Allard JP, Guttman DS, Conner ME, Winer S, Winer DA. Nat Commun. 2019 Aug 13;10(1):3650. doi: 10.1038/s41467-019-11370-y.

  8. Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity. Lin YH, Luck H, Khan S, Schneeberger PHH, Tsai S, Clemente-Casares X, Lei H, Leu YL, Chan YT, Chen HY, Yang SH, Coburn B, Winer S, Winer DA. Int J Obes (Lond). 2019 Apr 3. doi: 10.1038/s41366-019-0340-1. 

  9. ֍ Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction. Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S. Nat Immunol. 2019 Jan;20(1):29-39. doi: 10.1038/s41590-018-0272-2. Epub 2018 Dec 11. Erratum in: Nat Immunol. 2019 Mar 12;:.

  10. The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4). Lavine KJ, Pinto AR, Epelman S, Kopecky BJ, Clemente-Casares X, Godwin J, Rosenthal N, Kovacic JC. J Am Coll Cardiol. 2018 Oct 30;72(18):2213-2230. doi: 10.1016/j.jacc.2018.08.2149. Review.

  11. Isolation and Identification of Extravascular Immune Cells of the Heart. Aronoff L, Epelman S, Clemente-Casares X. J Vis Exp. 2018 Aug 23;(138). doi: 10.3791/58114.

  12. Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection. Tsai S, Clemente-Casares X, Zhou AC, Lei H, Ahn JJ, Chan YT, Choi O, Luck H, Woo M, Dunn SE, Engleman EG, Watts TH, Winer S, Winer DA. Cell Metab. 2018 Dec 4;28(6):922-934.e4. doi: 10.1016/j.cmet.2018.08.003. Epub 2018 Aug 30.

  13. ֍ A CD103+ Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis. Clemente-Casares X, Hosseinzadeh S, Barbu I, Dick SA, Macklin JA, Wang Y, Momen A, Kantores C, Aronoff L, Farno M, Lucas TM, Avery J, Zarrin-Khat D, Elsaesser HJ, Razani B, Lavine KJ, Husain M, Brooks DG, Robbins CS, Cybulsky M, Epelman S. Immunity. 2017 Nov 21;47(5):974-989.e8. doi: 10.1016/j.immuni.2017.10.011.

  14. A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis. Hebbandi Nanjundappa R, Ronchi F, Wang J, Clemente-Casares X, Yamanouchi J, Sokke Umeshappa C, Yang Y, Blanco J, Bassolas-Molina H, Salas A, Khan H, Slattery RM, Wyss M, Mooser C, Macpherson AJ, Sycuro LK, Serra P, McKay DM, McCoy KD, Santamaria P. Cell. 2017 Oct 19;171(3):655-667.e17. doi: 10.1016/j.cell.2017.09.022.

  15. ֍ Expanding antigen-specific regulatory networks to treat autoimmunity. Clemente-Casares X, Blanco J, Ambalavanan P, Yamanouchi J, Singha S, Fandos C, Tsai S, Wang J, Garabatos N, Izquierdo C, Agrawal S, Keough MB, Yong VW, James E, Moore A, Yang Y, Stratmann T, Serra P, Santamaria P. Nature. 2016 Feb 25;530(7591):434-40. doi: 10.1038/nature16962. Epub 2016 Feb 17.

  16. Are obesity-related insulin resistance and type 2 diabetes autoimmune diseases? Tsai S, Clemente-Casares X, Revelo XS, Winer S, Winer DA. Diabetes. 2015 Jun;64(6):1886-97. doi: 10.2337/db14-1488. Review.

  17. Regulation of obesity-related insulin resistance with gut anti-inflammatory agents. Luck H, Tsai S, Chung J, Clemente-Casares X, Ghazarian M, Revelo XS, Lei H, Luk CT, Shi SY, Surendra A, Copeland JK, Ahn J, Prescott D, Rasmussen BA, Chng MH, Engleman EG, Girardin SE, Lam TK, Croitoru K, Dunn S, Philpott DJ, Guttman DS, Woo M, Winer S, Winer DA.

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