Marisol Jimenez Garcia

Renee C. Geck, Naomi G. Moresi, Leah M. Anderson, yEvo Students, Rebecca Brewer, Timothy R. Renz, M. Bryce Taylor, Maitreya J. Dunham

Summary: 

Yeast can adapt to grow in high concentrations of caffeine. In collaboration with high school students, we grew yeast in increasing concentrations of caffeine to select for ones better adapted to caffeine. We sequenced these yeast to identify mutations that promote growth in caffeine, and showed they are related to pumping caffeine out of the cell, or changing pathways within the cell that are otherwise blocked by caffeine.

Complete Paper is available on the on the bioRxiv preprint server for Biology and is titled “Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways”