業績 / Achievements

原著論文 / Original papaer

2024.4~

1. Shigehito Osawa, A water-soluble polymer having blue color and metal-ligand property derived from dipicolylamide structures. Polymer Journal, in press, https://doi.org/10.1038/s41428-025-01054-4

2. Victor Marx, Yuki Mochida, Shigehito Osawa, Theofilus A. Tockary, Jumpei Norimatsu, Hidetomo Yokoo, Makoto Oba, Satoshi Uchida. Poly(sarcosine) and poly(1-ethyl-1-oxazoline) tethered to mRNA provide stealth properties to mRNA polyplexes. ACS Appl. Nano Mater. 2025, 8, 27, 13628–13638  https://doi.org/10.1021/acsanm.5c00636

3. Yoshikatsu Akiyama*, Shigehito Osawa*, Ken Masamune, Yoshihiro Muragaki. Alternation of the upper critical solution temperature (UCST) behavior of the nonionic polymer poly(N-acryloyl-nipecotamide) by its terminal group. European Polymer Journal, 2024, 220, 113454. https://doi.org/10.1016/j.eurpolymj.2024.113454  

4. Ryota Teshima, Shigehito Osawa, Kaoru Hirose, Yayoi Kawano, Akihiko Kikuchi, Takehisa Hanawa, Hidenori Otsuka. Effect of CO2 release behavior on the crosslinking degree of algenate hydrogels prepared with CaCO3 and carbonated water. Materials Advances, 2024, 5, 6368-6372. https://doi.org/10.1039/D4MA00257A Selected as Front cover

5. Masahiro Asada, Hisakazu Tanaka, Yukie Suwa, Shigehito Osawa, Hidenor Otsuka. Improved pigment dispersibility in thick inks based on increased molecular dispersion of poorly water-soluble block copolymer. Dyes and Pigments, 2024, 226, 112140. https://doi.org/10.1016/j.dyepig.2024.112140

6. Masahiro Asada, Airi Wakai, Hisakazu Tanaka, Yukie Suwa, Yuuji Tamura, Mariko KouYama, Shigehito Osawa, Hidenor Otsuka. Investigation the effcet of the micelle structures of block and random copolymers on dye solubilization. Soft Matter, 2024, 20, 5040-5044. https://doi.org/10.1039/D4SM00009A

~2024.3

1. Shigehito Osawa* and Yoshikatsu Akiyama*. Mechanical properties of poly(N‐acryloyl‐glycinamide) hydrogels dependent on initiation number of the polymerization reaction. ChemistrySelect, 2024, 9(6), e202400244. https://doi.org/10.1002/slct.202400244

2. Ryota Teshima, Shigehito Osawa, Miki Yoshikawa, Yayoi Kawano, Hidenori Otsuka, and Takehisa Hanawa. Low-adhesion and low-swelling hydrogel based on alginate and carbonated water to prevent temporary dilation of wound sites. International Journal of Biological Macromolecules, 2024, 127928-127928. https://doi.org/10.1016/j.ijbiomac.2023.127928

3. Shohei Ishikawa, Kazutoshi Iijima, Kohei Sasaki, Masaaki Kawabe, Shigehito Osawa, and Hidenori Otsuka. Three-dimensional co-culture model employing silica nonwoven fabrics to enhance cell-to-cell communication of paracrine signaling between hepatocytes and fibroblasts. Biotechnology and Bioengineering, 2023, 120(7), 1961-1974. https://doi.org/10.1002/bit.28425 Selected as front cover.

4. Ryota Teshima, Shigehito Osawa, Yayoi Kawano, Takehisa Hanawa, Akihiko Kikuchi, and Hidenori Otsuka. Physicochemical properties of egg-box-mediated hydrogels with transiently decreased pH employing carbonated water. ACS Omega, 2023, 8(8), 7800-7807. https://doi.org/10.1021/acsomega.2c07552 Selected as supplementary cover.

5. Masahiko Asada, Hisakazu Tanaka, Yukie Suwa, Sachiko Irifune, Shigehito Osawa, and Hidenori Otsuka. Tuning pre-solution of an amphiphilic polymeric dispersant with low acid-value toward colored-ink preparation. Applied Sciences-Basel, 2023, 13(3), 1834, 1-14. https://doi.org/10.3390/app13031834

6. Shigehito Osawa*, Sosuke Kurokawa, and Hidenori Otsuka*. Controlled polymerization of metal complex monomers – fabrication of random copolymers comprising different metal species and nano-colloids. Chemical Communications, 2022, 58, 5273-5276. https://doi.org/10.1039/D1CC07265J

7. Shigehito Osawa*, Kenichi Kitanishi, Maho Kiuchi, Motoyuki Shimonaka, and Hidenori Otsuka*. Accelerated Redox reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain. Macromolecular Rapid Communications, 2021, 42, 2100274. https://doi.org/10.1002/marc.202100274 Selected as Back cover.

8. Shohei Ishikawa, Kazutoshi Iijima, Daisuke Matsukuma, Michihiro Iijima, Shigehito Osawa*, and Hidenori Otsuka*. An interpenetrating polymer network hydrogel with biodegradability through controlling self-assembling peptide behavior with hydrolyzable cross-linking networks. Materials Today Advances, 2021, 9, 100131, 1-8. https://doi.org/10.1016/j.mtadv.2021.100131  

9. Akira Matsumoto, Shigehito Osawa, Takahiro Arai, Yukie Maejima, Hidenori Otsuka, Yuji Miyahara. Potentiometric Determination of Circulating Glycoproteins by Boronic Acid End-Functionalized Poly(ethylene glycol)-Modified Electrode. Bioconjugate Chemistry, 2021, 32(2), 239-244. https://doi.org/10.1021/acs.bioconjchem.0c00657 Selected as Supplementary Cover.

10. Shigehito Osawa, Akira Matsumoto, Yukie Maejima, Toshihiro Suzuki, and Hidenori Otsuka. Direct observation of cell surface sialylation by atomic force microscopy employing boronic acid-sialic acid reversible interaction. Analytical Chemistry, 2020, 92(17), 11714-11720. https://doi.org/10.1021/acs.analchem.0c01705

11. Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A. Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada, and Kazunori Kataoka. Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Science Advances, 2020, 6, enab8133. https://doi.org/10.1126/sciadv.abb8133

12. Shigehito Osawa*, Masato Kashiwakura, Hiro Yamaguchi, and Hidenori Otsuka*. Influence of anchoring segments on methacrylate-based comb-type hydrophilic polymer segments coated on silica surfaces using the grafting-to method. Colloids and Interface Science Communications, 2020, volume 36, 100258. https://doi.org/10.1016/j.colcom.2020.100258

13. Beob Soo Kim, Shigehito Osawa, Jongmin Yum, Mitsuru Naito, and Kanjiro Miyata. Installation of a Thermoswitchable Hydrophobic Domain into a Unimer Polyion Complex for Enhanced Cellular Uptake of siRNA. Bioconjugate Chemistry, 2020, 31, 5, 1320-1326. https://doi.org/10.1021/acs.bioconjchem.0c00238

14. Shohei Ishikawa, Kazutoshi Iijima, Daisuke Matsukuma, Yukiyo Asawa, Kazuto Hoshi, Shigehito Osawa*, Hidenori Otsuka*. Interpenetrating Polymer Network Hydrogels via a One-pot and in Situ Gelation System Based on Peptide Self-Assembly and Orthogonal Cross-Linking for Tissue Regeneration. Chemistry of Materials, 2020, 32, 2353-2364. https://doi.org/10.1021/acs.chemmater.9b04725 Selected as Supplementary Cover. 

15. Shohei Ishikawa, Kazutoshi Iijima, Kohei Sasaki, Masaaki Kawabe, Shigehito Osawa, Hidenori Otsuka, Silica-based Nonwoven Fiber Fabricated by Electrospinning to promote Fibroblast Functions. Bulletin of the Chemical Society of Japan, 2020, 93(4), 477-481. https://doi.org/10.1246/bcsj.20190318

16. Shohei Ishikawa, Kazutoshi Iijima, Daisuke Matsukuma, Michihiro Iijima, Shigehito Osawa*, Hidenori Otsuka*. Enhanced function of chondrocytes in a chitosan‐based hydrogel to regenerate cartilage tissues by accelerating degradability of the hydrogel via a hydrolysable crosslinker. Journal of Applied Polymer Science, 2020, 137(19), 48893.https://doi.org/10.1002/app.48893

Selected as Front cover.

17. Beob Soo Kim, Shigehito Osawa, Mitsuru Naito, Satomi Ogura, Rimpei Kamegawa, Hiroki Ishida, Hyun Jin Kim, Satoshi Uchida, and Kanjiro Miyata. A 50‐nm‐Sized Micellar Assembly of Thermoresponsive Polymer‐Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration. Advanced Therapeutics, 2020, 3, 1900123. https://doi.org/10.1002/adtp.201900123 Selected as Front cover

18. Theofilus A. Tockary, Wanling Foo, Anjaneyulu Dirisala, Qixian Chen, Satoshi Uchida, Shigehito Osawa, Yuki Mochida, Xueying Liu, Hiroaki Kinoh, Horacio Cabral, Kensuke Osada, and Kazunori Kataoka. Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer. ACS Nano, 2019, 13, 12732-12742. https://doi.org/10.1021/acsnano.9b04676

19. Beob Soo Kim, Hyun Jin Kim, Shigehito Osawa, Kotaro Hayashi, Kazuko Toh, Mitsuru Naito, Hyun Su Min, Yu Yi, Ick Chan Kwon, Kazunori Kataoka and Kanjiro Miyata. Dually Stabilized Triblock Copolymer Micelles with Hydrophilic Shell and Hydrophobic Interlayer for Systemic Antisense Oligonucleotide Delivery to Solid Tumor. ACS Biomaterials Science and Engineering. 2019, 5, 5770-5780. https://doi.org/10.1021/acsbiomaterials.9b00384

20. Shohei Ishikawa, Daisuke Matsukuma, Kazutoshi Iijima, Michihiro Iijima, Shigehito Osawa*, Hidenori Otsuka*. N-Hydroxysuccinimide Bifunctionalized Triblock Cross-Linker Having Hydrolysis Property for a Biodegradable and Injectable Hydrogel System. ACS Biomaterials Science and Engineering. 2019, 5, 5759-5769.　https://doi.org/10.1021/acsbiomaterials.9b00218

21. Shigehito Osawa*, Riichi Takahashi, Remi Watanabe, Sayaka Kubo and Hidenori Otsuka*. Increase in the Apparent Intercalation Ability of a Platinum Complex via Multivalency by Installation into the Sidechain of a Graft Copolymer and Observation of Structural Changes in the Intercalated DNA. RSC Advances, 2019, 9, 26429-26434. https://doi.org/10.1039/C9RA03485D Selected as Editors’ Collection ‘Metals in medicine’. 

22. Anjaneyulu Dirisala, Satoshi Uchida, Theofilus Agrious Tockary, Naoto Yoshinaga, Junjie Li, Shigehito Osawa, Lahari Gorantla, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka, Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability. Journal of Drug Targeting. 2019, 27 Issue5-6, 670-680. https://doi.org/10.1080/1061186X.2018.1550646

23. Mitsuru Naito, Ryota Azuma, Hiroyasu Takemoto, Mao Hori, Naoto Yoshinaga, Shigehito Osawa, Rinpei Kamegawa, Hyun Jin Kim, Takehiko Ishii, Nobuhiro Nishiyama, Kanjiro Miyata and Kazunori Kataoka. Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer targeted siRNA delivery. Journal of Biomaterials Science, 2017, 28, 1109-1123. https://doi.org/10.1080/09205063.2017.1301775

24. Shigehito Osawa, Takehiko Ishii, Hiroyasu Takemoto, Kensuke Osada and Kazunori Kataoka. A facile amino-functionalization of poly(2-oxazoline)s’ distal end through sequential azido end-capping and Staudinger reaction. European Polymer Journal, 2017, 88, 553-561. https://doi.org/10.1016/j.eurpolymj.2016.11.029

25. Theofilus Agrios Tockary, Kensuke Osada, Yusuke Motoda, Shigehiro Hiki, Qixin Chen, Kaori Machitani Takeda, Anjaneyulu Dirisala, Shigehito Osawa and Kazunori Kataoka. Rod-to-grobule transition of pDNA/PEG-Poly(Lysine) polyplex micelles induced by a collapsed balance between DNA rigidity and PEG crowdedness. Small, 2016, 12, 1193-1200. Selected as Back Cover. https://doi.org/10.1002/smll.201501815

26. Shigehito Osawa, Kensuke Osada, Shigehiro Hiki, Anjaneyulu Dirisala, Takehiko Ishii and Kazunori Kataoka. Polyplex micelles with double-protective compartments of hydrophilic shell and thermo-switchable palisade of poly(oxazoline)-based block copolymers for promoted gene transfection. Biomacromolecules, 2016, 17, 354-361.https://doi.org/10.1021/acs.biomac.5b01456

27. Anjaneyulu Dirisala, Kensuke Osada, Qixin Chen, Theofilus Agrios Tockary, Kaori Machitani, Shigehito Osawa, Xueying Liu, Takehiko Ishii, Kanjiro Miyata, Makoto Oba, Satoshi Uchida, Keiji Itaka and Kazunori Kataoka. Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials, 2014, 15, 5359-5368. https://doi.org/10.1016/j.biomaterials.2014.03.037

28. Hiroyasu Takemoto, Kanjiro Miyata, Takehiko Ishii, Shota Hattori, Shigehito Osawa, Nobuhiro Nishiyama and Kazunori Kataoka. Accelerated polymer-polymer click conjugation by freeze-thaw treatment. Bioconjugate Chemistry, 2012, 23, 1503-1506. https://doi.org/10.1021/bc300182y Selected as Supplementary Cover.　 

総説 / Review

準備中