発表論文等

27. Karube R, Koike M, Ikuta T, Shiizaki K

Abortion in AhR-knockout mice and fetomaternal immunity

Reproductive Biology 2024 24, Issue 4 

26. Ito-Harashima S, Matano M, Onishi K, Nomura T, NakajimaS, Ebata S, Shiizaki K, Kawanishi M, Yagi T

Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids

Genes and Environment 2020 volume 42, Article number: 20

25.Totsuka Y, Maesako Y, Ono H, Nagai M, Kato M, Gi M, Wanibuchi H, Fukushima S, Shiizaki K, Nakagama H.

Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane.

Proc Jpn Acad Ser B Phys Biol Sci. 2020 96(5):180-187.

24. Shiizaki K.

Post-labeling/PAGE method for detection of DNA adducts DNA Electrophoresis, Methods and protocol

Methods in Moleculer biology 2020 Mar 2　pp 213-226

23. Shiizaki K, Kido K, Mizuta Y.

Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells

PLoS ONE 2019 14(11): e0224613.

22. Nozomi Akiba, Kazuhiro Shiizaki, Yoshitaka Matsushima, Osamu Endo, Kazuho Inaba, Yukari Totsuka. Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and　1,2-dichloropropane.

Mutagenesis 2017 May 17 Volume 32 Issue 4.

21. Shiizaki K, Kawanishi M, Yagi T.

Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor

Genes Environ. 2017 Apr 10;39:14. Review.

20. Matsui S, Ito-Harashima S, Sugimoto Y, Takada E, Shiizaki K, Kawanishi M, Yagi T. Development of yeast reporter assays for the enhanced detection of environmental ligands of thyroid hormone receptors α and β from Xenopus tropicalis.

Toxicol In Vitro. 2016 Aug 18;37:15-24.

19. Ito-Harashima S, Shiizaki K, Kawanishi M, Kakiuchi K, Onishi K, Yamaji R, Yagi T.

Construction of sensitive reporter assay yeasts for comprehensive detection of ligand activities of human corticosteroid receptors through inactivation of CWP and PDR genes.

J Pharmacol Toxicol Methods. 2015 Jul-Aug;74:41-52

18. Shiizaki K, Kawanishi M, Yagi T.

Microbial Metabolites of Omeprazole Activate Murine Aryl Hydrocarbon Receptor In Vitro and In Vivo.

Drug Metab Dispos. 2014 42(10):1690-1697.

17. Shiizaki K, Yoshikawa T, Takada E, Hirose S, Ito-Harashima S, Kawanishi M, Yagi T.

Development of yeast reporter assay for screening specific ligands of retinoic acid and retinoid X receptor subtypes.

J Pharmacol Toxicol Methods. 2014 69(3):245-52.

16. Shiizaki K, Ohsako S, Kawanishi M, Yagi T.

Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.　

Mol Pharmacol 2014 85(2):279-89.

15.　Ikuta T., Kobayashi Y., Kitazawa M., Shiizaki K., Itano N., Noda T., Pettersson S., Poellinger L., Fujii-Kuriyama Y., Taniguchi S., Kawajiri K.

ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice.

Carcinogenesis 2013 34(7):1620-7

14. Shiizaki K., Kawanishi M, YagiT.

Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells.

Mutation research 2013 750(1-2):77-85.

13. Shiizaki K, Asai S, Ebata S, Kawanishi M, Yagi T.

Establishment of Yeast Reporter Assay Systems to Detect Ligands of Thyroid Hormone Receptors alpha and beta.

Toxicol In Vitro. 2010 24(2):638-44.

12. Chu WL, Shiizaki K, Kawanishi M, Kondo M, Yagi T.

Differential response of various pharmaceuticals to human estrogen receptor a and b in newly-constructed yest reporter assays.

Genes and Environment Vol. 31 2009 , No. 3 p.80-86

11. Kawakami T, Ito T, Ohsako S, Shiizaki K, Murakami Y, Hirowatari K, Sato M, Tohyama C.

Possible Involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats,

J Toxicol Sci. 2009 34(2):209-220.

10. Chu WL, Shiizaki K, Kawanishi M, Kondo M, Yagi T.

Validation of a New Yeast-based Reporter Assay Consisting of Human Estrogen Receptors alpha/beta and Coactivator SRC-1: Application for Detection of Estrogenic Activity in Environmental Samples.

Environmental Toxicology 2009 Volume 24, Issue 5, pages 513–521\

9.　Shiizaki K, Ohsako S, Kawanishi M, Yagi T.

Omeprazole Alleviates Benzo[a]pyrene Cytotoxicity by Inhibition of CYP1A1 Activity in Human and Mouse Hepatoma Cells.

Basic &Clinical Pharmacology & Toxicology，2008 103(5):468-475.

8.　Kawanishi M, Kondo M, Shiizaki K, Chu WL, Terasoma Y, Yagi T.

Construction of a Reporter Yeast Strain to Detect Estrogen Receptor Signaling through Aryl Hydrocarbon Receptor Activation.

Environmental Science & Technology, 2008 42 (18), 6897–6902

7.　Goryo K, Suzuki A, Del Carpio CA, Siizaki K, Kuriyama E, Mikami Y, Kinoshita K, Yasumoto K, Rannug A, Miyamoto A, Fujii-Kuriyama Y, Sogawa K.

Identification of amino acid residues in the Ah receptor involved in ligand binding.

Biochem Biophys Res Commun. 2007 Mar 9;354(2):396-402.

6.　Sarkar P, Shiizaki K, Yonemoto J, Sone H.

Activation of telomerase in BeWo cells by estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin in co-operation with c-Myc.

Int J Oncol. 2006 28(1):43-51.

5.　Shiizaki K, Ohsako S, Koyama T, Nagata R, Yonemoto J, Tohyama C.

Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.

Toxicol Lett. 2005 160(1):22-33.

4.　Suzuki Y, Goto K, Shiizaki K, Omiya Y, Ishige A, Komatsu Y, Kamei J.

Antinociceptive effect of U-50488H, a kappa-opioid agonist, in streptozotocin-induced diabetic mice.

J Pharm Pharmacol. 2001 53(4):521-526.

3.　Shiizaki K,Goto K, Ishige A.

Identification of differentially expressed gene in ovariectomized rat pituitary normalized by Unkei-to. Res Commun. Pharmcology and Toxicology. 2001 NOS;6 (1,2):125-133

2.　Shiizaki K, Muramatsu M, Ogawa S, Inoue S, Goto K, Ishige A, Sasaki H.

Phytoestrogen activity of Emodin, an anthraquinone derivative isolated from Rheum palamatum.　Res Commun. Pharmcology and Toxicology. 2000 NOS;5(3,4):179-189

1.　Shiizaki K, Goto K, Ishige A, Komatsu Y.

Bioassay of phytoestrogen in herbal medicine used for postmenopausal disorder using transformed MCF-7 cells.

Phytother Res. 1999 13(6):498-503.

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