Embedded Files
論文、著書、学会発表
＜論文＞
Arai Y, Nishino K. “Epigenetic mutagen-like environmental chemicals alter neural differentiation of human induced pluripotent stem cells” The Journal of Toxicological Sciences. 48:571-583. 2023.
Sekiya A, Takasawa K, Arai Y, Horike S, Akutsu H, Umezawa A, Nishino K. "Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells" Regenerative Therapy. 21, 620-630, 2022.
Shionoya K, Suzuki T, Takada M, Sato K, Onishi S, Dohmae N, Nishino K, Wada T, Linhardt RJ, Toida T, Higashi K. "Comprehensive analysis of chondroitin sulfate and aggrecan in the head cartilage of bony fishes: Identification of proteoglycans in the head cartilage of sturgeon" Int J Biol Macromol. 208, 333-342, 2022.
Nishino K, Takasawa K, Okamura K, Arai Y, Sekiya A, Akutsu H, Umezawa A. "Identification of an epigenetic signature in human induced pluripotent stem cells using a linear machine learning model." Human Cell. 34, 99-110, 2021.
Sekiya A, Takasawa K, Arai Y, Torisu S, Nishino K. "Dog Steroidogenic Factor-1: Molecular cloning and analysis of epigenetic regulation" J Vet Med Sci. 82(6): 681-689, 2020.
Arai Y, Umeyama K, Okazaki N, Nakano K, Nishino K, Nagashima H, Ohgane J. “DNA methylation ambiguity in the Fibrillin-1 (FBN1) CpG island shore possibly involved in Marfan syndrome” Scientific Reports. 10:5287. 2020.
Nishino K, Arai Y, Takasawa k, Toyoda M, Yamazaki-Inoue M, Sugawara T, Akutsu H, Nishimura K, Ohtaka M, Nakanishi M, Umezawa A. “Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors” Regenerative Therapy. 9: 71-78. 2018.
Takasawa K, Arai Y, Yamazaki-Inoue M, Toyoda M, Akutsu H, Umezawa A, Nishino K. “DNA hypermethylation enhanced telomerase reverse transcriptase expression in human induced pluripotent stem cells” Human Cell. 31(1): 78-86. 2018.
Wakitani S, Yokoi D, Hidaka Y, Nishino K. “The differentially DNA-methylated region responsible for expression of runt-related transcription factor 2”. J Vet Med Sci. 79(2):230-237. 2017.
Nishino K, Umezawa A. “DNA methylation dynamics in human induced pluripotent stem cells”. Hum Cell. 29(3): 97-100. 2016. Review.
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Imai H, Kano K, Fujii W, Takasawa K, Wakitani S, Hiyama M, Nishino K, Kusakabe KT, Kiso Y. “Tetraploid Embryonic Stem Cells Maintain Pluripotency and Differentiation Potency into Three Germ Layers”. PLoS One. 10(6): e0130585. 2015.
Kaneko S, Bonasio R, Saldaña-Meyer R, Yoshida T, Son J, Nishino K, Umezawa A, Reinberg D. “Interaction between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin”. Mol Cell. 53(2):290-300. 2014.
Yamagata Y, Nishino K, Takaki E, Sato S, Maekawa R, Nakai A, Sugino N. “Genome-wide DNA methylation profiling in cultured eutopic and ectopic endometrial stromal cells”. PLoS One. 9(1):e83612. 2014.
Wakitani S*, Torisu S*, Yoshino T, Hattanda K, Yamato O, Tasaki R, Fujita H, Nishino K. “Multiple acyl-CoA dehydrogenation deficiency (glutaric aciduria type II) with a novel mutation of electron transfer flavoprotein-dehydrogenase in a cat”. JIMD Reports. 13:43-51. 2014.
*These authors contributed equally to this work.
Yugawa T, Nishino K, Ohno SI, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T. “Non-canonical NOTCH signaling limits self-renewal of human epithelial and iPS cells through ROCK activation.” Mol Cell Biol. 33(22):4434-47. 2013.
Hiura H, Toyoda M, Okae H, Sakurai M, Miyauchi N, Sato A, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Nishino K, Umezawa A, Arima T. “Stability of genomic imprinting in human induced pluripotent stem cells”. BMC Genet. 14(1):32. 2013.
Michael IP, Monetti C, Chiu AC, Zhang P, Baba T, Nishino K, Agha-Mohammadi S, Woltjen K, Sung HK, Nagy A. “Highly efficient site-specific transgenesis in cancer cell lines”. Mol Cancer. 11(1):89. 2012.
Sugawara T, Nishino K, Umezawa A, Akutsu H. “Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells”. Stem Cell Res Ther. 3:8. 2012. Review
Nishino K, Hattori N, Sato S, Arai Y, Tanaka S, Nagy A, Shiota K. “Non-CpG methylation occurs in the regulatory region of Sry gene”. J Reprod Dev. 57(5), 586-593. 2011.
Nishino K, Toyoda M, Yamazaki-Inoue M, Fukawatase Y, Chikazawa E, Sakaguchi H, Akutsu H, Umezawa A. “DNA methylation dynamics in human induced pluripotent stem cells over time”. PLoS Genetics 7(5): e1002085. 2011.
Saito S, Onuma Y, Ito Y, Tateno H, Toyoda M, Akutsu H, Nishino K, Chikazawa E, Fukawatase Y, Miyagawa Y, Okita H, Kiyokawa N, Shimma Y, Umezawa A, Hirabayashi J, Horimoto K, Asashima M. “Possible linkages between the inner and outer cellular states of human induced pluripotent stem cells.” BMC Syst Biol 5 Suppl 1: S17. 2011.
Monetti C, Nishino K, Biechele S, Zhang P, Baba T, Woltjen K, Nagy A. “PhiC31 integrase facilitates genetic approaches combining multiple recombinases.” Methods. 53, 380-5. 2011.
Nishino K, Toyoda M, Yamazaki-Inoue M, Makino H, Fukawatase Y, Chikazawa E, Takahashi Y, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A.“Defining Hypo-Methylated Regions of Stem Cell-Specific Promoters in Human iPS Cells Derived from Extra-Embryonic Amnions and Lung Fibroblasts.” PLoS One 5(9): e13017. 2010.
Nagata S, Toyoda M, Yamaguchi S, Hirano K, Makino H, Nishino K, Miyagawa Y, Okita H, Kiyokawa N, Nakagawa M, Yamanaka S, Akutsu H, Umezawa A, Tada T. “Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.” Genes Cells. 14, 1395-404. 2009.
Makino H, Toyoda M, Matsumoto K, Saito H, Nishino K, Fukawatase Y, Machida M, Akutsu H, Uyama T, Miyagawa Y, Okita H, Kiyokawa N, Fujino T, Ishikawa Y, Nakamura T, Umezawa A.“Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS.” Exp Cell Res. 315, 2727-40. 2009.
Hattori N, Imao Y, Nishino K, Hattori N, Ohgane J, Yagi S, Tanaka S, and Shiota K. “Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.” Genes Cells. 12, 387-396. 2007.
Nakamura K, Murata C, Ito M, Iwamori T, Nishimura S, Hisamatsu S,Sonoki S, Nakayama A, Suyama E, Kawasaki H, Taira K, Nishino K, and Tachi C. “Design of hammerhead ribozymes that cleave murine Sry mRNA in vitro and in vivo.” J Reprod Dev. 52, 73-80. 2006.
Ko Y.G, Nishino K, Hattori N, Arai Y, Tanaka S, and Shiota K. "Stage-by-stage change in DNA methylation status of Dnmt1 locus during mouse early development." J Biol Chem 280, 9627-9634.2005.
Nishino K, Hattori N, Tanaka S, and Shiota K. "DNA methylation-mediated control of Sry gene expression in mouse gonadal development." J Biol Chem 279, 22306-22313.2004.
Hattori N, Nishino K, Ko Y.G, Ohgane J, Tanaka S, and Shiota K. "Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells." J Biol Chem 279, 17063-17069. 2004.
Yokouchi K, Ito M, Nishino K, Yamanouchi K, Naito K, Suzawa M, Kato S, Hakamata Y, Endo H, and Tojo H. "Stage-specific regulatory element of mouse Sry gene." Mol Reprod Dev 64, 389-396. 2003.
Shiota K, Kogo Y, Ohgane J, Imamura T, Urano A, Nishino K, Tanaka S, and Hattori N. "Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice." Genes Cells 7, 961-969. 2002.
Nishino K, Yamanouchi K, Naito K, and Tojo H. "Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry." Dev Growth Differ 44, 35-43. 2002.
Nishino K, Yamanouchi K, Naito K, and Tojo H. "Characterization of mesonephric cells that migrate into the XY gonad during testis differentiation." Exp Cell Res 267, 225-232. 2001.
Nishino K, Kato M, Yokouchi K, Yamanouchi K, Naito K, and Tojo H. "Establishment of fetal gonad/mesonephros coculture system using EGFP transgenic mice." J Exp Zool 286, 320-327. 2000.
Hirota O, Nishino K, Toyooka Y, Kodama T, Tanaka S, Yamanouchi K. Tojo H, Tachi C. "Effects of Transfected Human and Mouse SRY/Sry Genes upon the Expression of Hypothetical SRY-Cascade Genes in Cultured Mouse Sertoli Cell Line, TM-4." J Reprod Dev 42, 255-263. 1996.
＜著書＞
新井良和, 西野光一郎: "エピゲノム医療「再生医療に向けたエピゲノムによるiPS細胞の特性解析」", 遺伝子医学, 31号, 61-67, 2020. 1.1発行
関谷麻杜, 鳥巣至道, 西野光一郎: "コンパニオンアニマル再生医療における間葉系幹細胞 -自験例を中心に", 医学のあゆみ, Vol.272, 1075-1080, 2020.
高澤建, 新井良和, 西野光一郎: 「第6節 機械学習とiPS細胞研究から得られるバイオビッグデータの融合」, 再生医療の開発戦略と最新研究事例集, 298-305, 2019.2.28発刊 （株）技術情報協会
西野光一郎, 梅澤明弘: 「幹細胞・iPS細胞研究におけるエピジェネティクスと医療応用」, エピジェネティクスの産業応用, 362-369, 2014. 4月30日発行
梅澤明弘, 西野光一郎: 「再生医療」, エピジェネティクスキーワード事典, 235-241, 2013. 11月発行
梅澤明弘, 西野光一郎: "エピジェネティクスと病気「再生医療とエピジェネティクス」", 遺伝子医学MOOK, 第25巻, 271-276, 2013. 8月31日発行
Nishino K, and Umezawa A: “Induced Pluripotent Stem Cells from Human Extra-Embryonic Amnion Cells: Role of DNA Methylation in Maintaining Stemness” Stem Cells and Cancer Stem Cells. Vol. 4, 59-65, 2012.
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西野光一郎, 梅澤明弘:「iPS細胞におけるメチル化動態」, 医学のあゆみ, 第243,321-322,2012.10月27日
西野光一郎, 梅澤明弘: "幹細胞のメディカルサイエンス「iPS細胞とゲノムメチル化ダイナミクス」", 実験医学増刊, 第30巻, 1556-1561,2012.６月
西野光一郎, 梅澤明弘: "次世代iPS医療「iPS細胞とゲノムメチル化」", 医学のあゆみ, 第239,1259-1264,2011.12月
梅澤明弘, 西野光一郎:"エピジェネティクスと疾患「再生医療とエピジェネティクスの接点」", 実験医学増刊, 第28巻, 2546-2551,2010.
西野光一郎, 梅澤明弘:"広がる’エピジェネティック疾患'研究の世界「エピジェネティクスと再生医療」", 医学のあゆみ, 第225, 588-592,2008.
梅澤明弘, 西野光一郎:"エピジェネティクス-最近の動向と疾患—各種疾患におけるエピジェネティクス研究の新展開「再生医療とエピジェネティクス」", 最新医学, 第63巻, 833-841, 2008.
塩田邦郎, 田中智, 服部中, 大鐘潤, 今村拓也, 西野光一郎, 鈴木雅子, 小田真由美, 服部奈緒子, 冨川順子, ユリアクレメンスカ, 岩谷美沙:"DNAメチル化研究法", 学会出版センター, 2006.
Nishino K, Ohgane J, Suzuki M, Hattori N and Shiota K: “Methylation in Embryonic Stem cells in vitro.” Methods Mol Biol. Vol. 329, 421-425, 2006.
西野光一郎, 塩田邦郎："エピジェネティクスと遺伝子発現機構「DNAメチル化による発生プログラム」", 実験医学増刊, 第21号, 1499-1507, 2003.
＜学会発表＞
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