Gene Regulation of Ethanol metabolism

There are 17 two component systems were found in A. baumannii. EmaSR was found to regulate ethanol and acetate metabolism in this lab. 

1.Y.-W. Huang; H.-Y. Shu; G.-H. Lin. 2024. Gene expression of ethanol and acetate metabolic pathways in the Acinetobacter baumannii EmaSR regulon. Microorganisms. 12(2):331 

2.H.-Y. Shu, ; Y.-W. Huang, ; P.-Y. Tsai, ; K.-S Hsieh.; G.-H. Lin. Role of EmaSR in Ethanol Metabolism by Acinetobacter baumannii. Int. J. Mol. Sci. 2022, 23, 12606. https://doi.org/10.3390/ijms232012606 

There are 7 genes were annotated as alcohol dehydrogenase (ADH) in A. baumannii. All of them were annotated as NAD+-dependent ADH. Three of them are iron-containing ADH and three of them are zinc-containg ADH. Only one of them are short-chain ADH. We are working on the elucidation of  the function of all of those genes. 

The study of three FeADH have been published in the following article:

G.-H. Lin,  M.-C. Hsieh, H.-Y. Shu*. 2021.Role of Iron-Containing Alcohol Dehydrogenases in Acinetobacter baumannii ATCC 19606 Stress Resistance and Virulence. International Journal of Molecular Sciences. 22(18) 9921. https://doi.org/10.3390/ijms22189921