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Our research aims to develop innovative synthetic methodologies, therapeutic approaches, and chemical biology tools, and apply them to solving pressing problems of biological and medical importance. New synthetic strategies (e.g. late-stage C–H functionalization and electrocatalysis) are applied to develop new reaction methods for the controlled and sustainable synthesis of complex organic molecules including those with biological activity. In addition, our exploration of new therapeutic approaches (e.g. targeted covalent inhibition and targeted protein degradation) provides new opportunities to address traditionally “undruggable” disease targets. We combine these efforts to achieve the research goal of identifying small-molecule probes and drug candidates that specifically remove/inhibit disease-causing proteins in cells and animal models and ultimately impact human health. Representative research directions include:
Organoboron chemistry and its applications in drug discovery
Late-stage functionalization & Electrocatalysis
Targeted protein inhibition and degradation for COVID-19 and cancer drug discovery
Group News
Group News
2025/01 We are excited to welcome undergraduate students Alexander Entchev and Shaili Gandhi!
2024/10 We are excited to welcome graduate students Ifeoluwa Adedotun, Victor Nwankwo, and Amritha Sajeevan!
2024/08 We are excited to welcome undergraduate students Saimon Yohannes and Leia Bowden!
2024/07 We are excited to welcome summer graduate student Griffin Batson!
2024/05 We are excited to welcome Ryan Pohorenec in TAMU MD-PhD program for summer research!
2023/10 We are excited to welcome first-year graduate students: Thinh (John) Nguyen, Sophea Pa, and Ramy Yousef!
© Xu Group
© Xu Group
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