Publications and Patents
2024
55. T. Yang, S. Tang, J. Feng, X. Yan, Lipid Isobaric Mass Tagging for Enhanced Relative Quantification of Unsaturated sn-Positional Isomers. ACS Measurement Science Au. 2024, 4, 213–222. DOI: 10.1021/acsmeasuresciau.3c00062
54. Kar, N., Huang, C., Sridhar, S., Edwards, M., Marie, M., Paranzino, B., Yan, X., Willets, K., Ye, X., Skrabalak, S. Magnifying Minds: Exploring the Concepts of Size and Scale with a Public Mural and Integrated Activities. J. Chem. Educ. 2024. DOI: 10.1021/acs.jchemed.4c00111.
53. K. Kulesa, E. Hirtzel, V. Nguyen, D. Freitas, M. Edwards, X. Yan, L. Baker. Interfacing High-Throughput Electrosynthesis and Mass Spectrometric Analysis of Azines. Anal. Chem. 2024, 96, 21, 8249–8253. DOI: 10.1021/acs.analchem.4c01110
52. J. Y. Noh, N.Farhataziz, M. T. Kinter, X. Yan, Y. Sun, Colonic Dysregulation of Major Metabolic Pathways in Experimental Ulcerative Colitis. Metabolites 2024, 14, 194. DOI:10.3390/metabo14040194
51. Y. J. Sheng, S. A. Kuo, T. Yang, H. E. Zhang, D. H. Russell, X. Yan, S. Xu, W. R. Liu, C. A. Fierke, BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease. Biochemistry 2024, 63, 402–406. DOI: 10.1021/acs.biochem.3c00685
2023
50. H. Chen, et. al. Meeting Report on the 3rd Chinese American Society for Mass Spectrometry Conference—Advancing Biological and Pharmaceutical Mass Spectrometry, Biomedical Chromatography, 2023, e5795. DOI:10.1002/bmc.5795
49. M.E. Edwards, D.P. Freitas, E.A. Hirtzel, N. White, H. Wang, L.A. Davidson, R.S Chapkin, Y Sun, X. Yan, Interfacial Electromigration for Analysis of Biofluid Lipids in Small Volumes. Anal. Chem. 2023, 95, 18557–18563. DOI: 10.1021/acs.analchem.3c04309.
48. A. Sengupta, M. E. Edwards, X. Yan, Dual Metal Electrolysis in Theta Capillary for Lipid Analysis, Int. J. Mass Spectrom. 2023, 494, 117137. DOI: 10.1016/j.ijms.2023.117137 (Invited article in honor of Lidia Gall and Vicki Wysocki, the recipients of the 2022 Thomson Medal)
47. E. Hirtzel, M. Edwards, D. Freitas, Z. Liu, F. Wang, X. Yan, Aziridination-Assisted Mass Spectrometry of Nonpolar Sterol Lipids with Isomeric Resolution, J. Am. Soc. Mass Spectrom. 2023, 34, 1998-2005. DOI: 10.1021/jasms.3c00161. Published in the special focus issue “Ion Chemistry and Electrospray Ionization” in honor of Evan Williams.
46. T. Qiao, M. E. Edwards, X. Tang, X. Yan, D. H. Son, Efficient and Selective Photogeneration of Stable N-Centered Radicals via Controllable Charge Carrier Imbalance in Cesium Lead Halide Nanocrystals, J. Am. Chem. Soc. 2023, 145, 16862–16871. DOI: 10.1021/jacs.3c05323.
45. D. P. Freitus, X. Chen, E. A. Hirtzel, M. E. Edwards, J. Kim, H. Wang, Y. Sun, K. I. Kocurek, D. Russell, X. Yan, In Situ Droplet-Based On-Tissue Chemical Derivatization for Lipid Isomer Characterization using LESA, Anal. Bioanal. Chem. 2023, 415, 4197–4208. DOI: 10.1007/s00216-023-04653-3 (Collection of Young Investigators in (Bio-) Analytical Chemistry) Selected as a Paper in Forefront.
44. K. S. Yang, L. R. Blankenship, S. Kuo; Y. Sheng; P. Li; C. A. Fierke; D. H. Russell; X. Yan; S. Xu; W. R. Liu, A Novel Y-Shaped, S–O–N–O–S-Bridged Cross-Link between Three Residues C22, C44, and K61 Is Frequently Observed in the SARS-CoV-2 Main Protease, ACS Chem. Biol. 2023, 18, 449–455. DOI: 10.1021/acschembio.2c00695
2022
43. T. Yang, S. Tang, S. Kuo, D. Freitas, M. Edwards, H. Wang, Y. Sun, X. Yan. Lipid Mass Tags via Aziridination for Probing Isomeric Structures and Accurate Quantification. Angew. Chem. Int. Ed. 2022, 61, e202207098. DOI: 10.1002/ange.202207098.
42. H. Cheng, T. Yang, M. Edwards, S. Tang, S. Xu, X. Yan. Picomole-Scale Transition Metal Electrocatalysis Screening Platform for Discovery of Mild C–C Coupling and C–H Arylation through in Situ Anodically Generated Cationic Pd. J. Am. Chem. Soc. 2022, 144, 1306–1312. DOI: 10.1021/jacs.1c11179
41. S. Kuo, S. Tang, D. H. Russell, X. Yan. Characterization of Lipid Carbon–Carbon Double-Bond Isomerism via Ion Mobility-Mass Spectrometry (IMS-MS) Combined with Cuprous Ion-Induced Fragmentation. Int. J. Mass Spectrom. 2022, 479, 116889. DOI: 10.1016/j.ijms.2022.116889
40. K. S. Yang, S. Kuo, L. R. Blankenship, Z. Z. Geng, S. G. Li, D. H. Russell, X. Yan, S. Xu, W. R. Liu. Repurposing Halicin as a potent covalent inhibitor for the SARS-CoV-2 main protease. CRCHBI. 2022, 2, 100025. DOI: 10.1016/j.crchbi.2022.100025.
39. S. Tang, X. Chen, Y. Ke, F. Wang, X. Yan. Voltage-Controlled Divergent Cascade of Electrochemical Reactions for Characterization of Lipids at Multiple Isomer Levels Using Mass Spectrometry. Anal. Chem. 2022, 94, 12750–12756. DOI: 10.1021/acs.analchem.2c02375.
38. X. Chen. S. Tang, D. Freitas, E. Hirtzel, H. Cheng, X. Yan. Characterization of Glycerophospholipids at Multiple Isomer Levels via Mn(II)-Catalyzed Epoxidation. Analyst, 2022, 147, 4838-4844. DOI: 10.1039/D2AN01174C
37. Y. Zhu, S. Schrecke, S. Tang, M.T. Odenkirk, T. Walker, L. Stover, J. Lyu, T. Zhang, D. Russell, E.S. Baker, X. Yan, A. Laganowsky. Cupric Ions Selectively Modulate TRAAK-Phosphatidylserine Interactions. J. Am. Chem. Soc. 2022, 144, 7048-7053. DOI: 10.1021/jacs.2c00612
2021
36. D. Kuai, H. Cheng, K. Kuan, X. Yan. Accelerated Five-Component Spiro-Pyrrolidine Construction at The Air-Liquid Interface. Chem. Commun. 2021, 57, 3757-3760. DOI: 10.1039/D1CC00574J
35. S. Tang, L. Fan, H. Cheng, X. Yan. Incorporating Electro-Epoxidation into Electrospray Ionization Mass Spectrometry for Simultaneous Analysis of Negatively and Positively Charged Unsaturated Glycerophospholipids. J. Am. Soc. Mass Spectrom. 2021, 32, 2288-2295. DOI: 10.1021/jasms.0c00356
34. D. Freitas, X. Chen, H. Cheng, A. Davis, B. Fallon, X. Yan. Recent Advances of In‐Source Electrochemical Mass Spectrometry. ChemPlusChem 2021, 86, 434-445. DOI: 10.1002/cplu.202100030
33. X. Yan. Emerging microdroplet chemistry for synthesis and analysis. Int. J. Mass Spectrom. 2021, 468, 116639. DOI: 10.1016/j.ijms.2021.116639
32. D. A. Murphy, H. Cheng, T. Yang, X. Yan, Isaac M. Adjei. Reversing Hypoxia with PLGA-Encapsulated Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response to Tumor Spheroids. Mol. Pharmaceutics 2021, 18, 2935-2946. DOI: 10.1021/acs.molpharmaceut.1c00085
2020
31. H. Cheng, S. Tang, T. Yang, S. Xu, X. Yan. Accelerating Electrochemical Reactions in a Voltage-Controlled Interfacial Microreactor. Angew. Chem. Int. Ed. 2020, 59, 19862-19867. DOI: 10.1002/anie.202007736
30. S. Tang, H. Cheng, X. Yan. On‐Demand Electrochemical Epoxidation in Nano‐Electrospray Ionization Mass Spectrometry to Locate Carbon‐Carbon Double Bonds. Angew. Chem. Int. Ed. 2020, 59, 209-214. DOI: 10.1002/anie.201911070
29. X. Yan, X. Zhao, Z. Zhou, A. McKay, A. Brunet, R. N. Zare. Cell-Type-Specific Metabolic Profiling Achieved by Combining Desorption Electrospray Ionization Mass Spectrometry Imaging and Immunofluorescence Staining. Anal. Chem. 2020, 71, 31-51. DOI: 10.1021/acs.analchem.0c02519
28. Z. Wei, Y. Li, R. G. Cooks, X. Yan. Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments. Annu. Rev. Phy. Chem. 2020, 71, 31-51. DOI: 10.1146/annurev-physchem-121319-110654
27. E. Gnanamani, X. Yan, R. N. Zare. Chemoselective N‐Alkylation of Indoles in Aqueous Microdroplets. Angew. Chem. Int. Ed. 2020, 59, 3069-3072. DOI: doi.org/10.1002/anie.201913069
26. X. Zhang, X.Ren, K. Chingin, J. Xu, X. Yan, H. Chen. Mass spectrometry distinguishing C=C location and cis/trans isomers: A strategy initiated by water radical cation. Anal. Chim. Acta 2020, 1139, 146-154. DOI: 10.1016/j.aca.2020.09.027
2019
25. Z. Jiang, K. Pflug, S. M. Usama, D. Kuai, X. Yan, R. Sitcheran, K. Burgess. Cyanine-Gemcitabine Conjugates as Targeted Theranostic Agents for Glioblastoma Tumer Cells. J. Med. Chem. 2019, 62, 9236-9245. doi: 10.1021/acs.jmedchem.9b01147
Pre Texas A&M Publications
24. S. Banerjee, A.C.Y. Wong, X. Yan, B. Wu, H. Zhao, R. J. Tibshirani, R.N. Zare, J. D. Brooks. Early detection of unilateral ureteral obstruction by desorption electrospray ionization mass spectrometry. Sci. Rep. 2019, 9, 11007. DOI: 10.1038/s41598-019-47396-x
23. D. Gao, F. Jin, X. Yan, and R. N. Zare. Selective synthesis in microdroplets of 2-phenyl-2,3-dihydrophthalazine-1,4-dione from phenyl hydrazine with phthalic anhydride or phthalic acid. Chem. Eur. J. 2019, 25, 1466-1471. DOI: 10.1002/chem.201805585
2018
23. X. Yan, Y. Lai, R. N. Zare. Preparative microdroplet synthesis of carboxylic acids from aerobic oxidation of aldehydes. Chem. Sci. 2018, 9, 5207-5211. DOI: 10.1039/C8SC01580E
21. Z. Zhou, X. Yan, Y. Lai, R. N. Zare. Fluorescence polarization anisotropy in microdroplets. J. Phys. Chem. Lett. 2018, 9, 2928-2932. DOI: 10.1021/acs.jpclett.8b01129
20. R. G. Cooks, X. Yan. Mass Spectrometry for Synthesis and Analysis. Annu. Rev. Anal. Chem. 2018, 11, 1-28. DOI: 10.1146/annurev-anchem-061417-125820
2017
19. X. Yan, X. Li, R. G. Cooks. Ambient ionization mass spectrometry measurement of aminotransferase activity. J. Am Soc. Mass. Spectrom. 2017, 28, 1175-1181. DOI: 10.1007/s13361-016-1591-x
18. X. Yan, H. Y. Cheng, S. Banerjee, R. N. Zare. Two-phase reactions in microdroplets without the use of a catalyst. Angew. Chem. Int. Ed. 2017, 56, 3562-3565. DOI: 10.1002/anie.201612308
17. H. Cheng, X. Yan, R. N. Zare. Two new devices for identifying electrochemical reaction intermediates with desorption electrospray ionization mass spectrometry. Anal. Chem. 2017, 89, 3191-3198. DOI: 10.1021/acs.analchem.6b05124
16. S. Banerjee, E. Gnanamani, X. Yan, R. N. Zare. Can all bulk-phase reactions be accelerated in microdroplets? Analyst 2017, 142, 1399-1402. DOI: 10.1039/C6AN02225A
15. X. Li, X. Yan, R. G. Cooks. Functionalization of saturated hydrocarbons using nitrogen ion insertion reactions in mass spectrometry. Int. J. Mass Spectrom. 2017, 418, 79-85. DOI: 10.1016/j.ijms.2016.11.017
2016
14. X. Yan, R. M. Bain, R. G. Cooks. Reaction acceleration in microdroplets revealed by mass spectrometry. Angew. Chem. Int. Ed. 2016, 55, 12960-12972. DOI: 10.1002/anie.201602270
13. X. Yan, R. M. Bain, Y. Li, R. Qiu, T. G. Flick, R. G. Cooks. On-line inductive electrospray ionization mass spectrometry as a process analytical technology tool to monitor the synthetic route to Anagliptin. Org. Process Res. Dev. 2016, 20, 940-947. DOI: 10.1021/acs.oprd.6b00039
12. R. M. Bain, X. Yan, S. A. Raab, S. T. Ayrton, T. G. Flick, R. Graham Cooks. On-line and off-line chiral analysis of reaction mixtures using the kinetic method. Analyst 2016, 141, 2441-2446. DOI: 10.1039/C6AN00100A
11. Y. Li, X. Yan, R. G. Cooks. The role of the interface in thin film and droplet accelerated reactions studied by competitive substituent effects. Angew. Chem. Int. Ed. 2016, 55, 3433-3437. DOI: 10.1002/anie.201511352
Before 2015
10. X. Yan, E. Sokol, X. Li, G. Li, S. Xu, R. G. Cooks. On-line reaction monitoring and mechanistic studies by mass spectrometry: Negishi cross-coupling, hydrogenolysis and reductive amination. Angew. Chem.Int. Ed. 2014, 23, 5931-5935. DOI: 10.1002/anie.201310493
9. R. D. Espy, M. Wleklinski, X. Yan, R. G. Cooks. Beyond the flask: reactions on the fly in ambient mass spectrometry. Trends Anal. Chem. 2014, 57,135-146. DOI:10.1016/j.trac.2014.02.008
8. R. Bain, C. J. Pulliam, X. Yan, K. Moore, R. G. Cooks. Mass spectrometry in organic synthesis: Claisen-Schmidt base-catalyzed condensation and Hammett equation. J. Chem. Ed. 2014, 91,1985-1989. DOI: 10.1021/ed500288m
7. X. Yan, R. Augusti, X. Li, R. G. Cooks. Chemical reactivity assessment using reactive paper spray mass spectrometry: Katritzky reaction. ChemPlusChem 2013, 78, 1142-1148. DOI: 10.1002/cplu.201300172
6. X. Yan, Y. Zhou, S. Liu. Optical imaging of tumors with copper-labeled rhodamine derivatives by targeting mitochondria. Theranostics 2012, 2, 988-998. DOI: 10.7150/thno.4818
5. Y. Zhou, Y. Kim, X. Yan, O. Jacobson, X. Chen, S. Liu. 64Cu-labeled lissamine rhodamine B: a promising PET radiotracer targeting tumor mitochondria. Mol. Pharm. 2011, 8, 1198-1208. DOI: 10.1021/mp200025m
4. S. Xu, X. Yan, Y. Chen, P. Xia, Z. Qian, D. Yu, Yi Xia, Z. Yang, S. L. Morris-Natschke, K.H. Lee. Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'- monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs. Bioorg. Med. Chem. 2010, 18, 7203-7211. DOI: 10.1016/j.bmc.2010.08.031
3. X. Yan, S. Xu, J. Wang, Y. Chen, P. Xia. Methyl 3β-methoxycarbonyl-4,4-dimethyl-17-oxo-16α-(3-oxobutyl)-16β-carboxylate. Acta Crystallogr. Sect. E 2009, E65, o1283. DOI: 10.1107/S1600536809017243
2. X. Yan, S. Xu, J. Wang, Y. Chen, P. Xia. N-tert-Butyl-5a-androstane-17ß-carboxamide. Acta Crystallogr. Sect. E, 2009, E65, o587. DOI: 10.1107/S1600536809005741
1. S. Xu, X. Yan, Q. Zhang, P. Xia, Y. Chen. Unexpected rearrangement in the reaction of 7-mercapto-4-methylcoumarin with 1-mono- and 1,1-dimethyl propargyl alcohols. Synth. Commun. 2007, 37, 3801-3808 . DOI: 10.1080/00397910701571615
Patents
5. Tandem Mass Tag for Lipid Quantitation, US Patent application number: US 63/171,846
4. On-Demand Electrochemical Reactions in Nano-Electrospray Ionization Mass Spectrometry for Biomolecular Analysis, United States provisional patent application number: 62/924,889
3. Reaction monitoring, US Patent App. 15/672,862
2. Synchronization of ion generation with cycling of a discontinuous atmospheric interface, PCT international application number: 13/887,911.1.
1. Ambient surface cleaning and sampling with continuous mass spectrometric analysis, PCT international application number: 62/036,186.