Shakira has ventured into many other businesses and industries. She appeared in the Colombian telenovela El Oasis in 1994, playing the character of Luisa Maria.^[157]

Shakira began her own beauty line, "S by Shakira", with parent company Puig, in 2010.^[158] Among the first perfumes it released included "S by Shakira" and "S by Shakira Eau Florale", along with lotions and body sprays. As of 2019, she has released 25 fragrances, not counting deluxe editions.^[159] On 17 September 2015, she was featured as a playable bird in the game Angry Birds POP! for a limited time, and also in a special tournament in the game Angry Birds Friends after a few weeks. On 15 October 2015, Love Rocks starring Shakira was the first video game that featured the pop star.^[160]

On 14 August 2015, at Disney's D23 Expo, it was announced that Shakira would play a character in the Disney animated movie Zootopia; in it, she would give voice to Gazelle, the biggest pop star in Zootopia. Shakira also contributed an original song to the film, titled "Try Everything", which was written and composed by Sia and Stargate.^[161][162] The film received universal critical acclaim with praise directed toward its animation, voice cast, characters, humor, screenplay, and themes about discrimination and social stereotypes.^[163][164] It opened to a record-breaking box office success in several countries and earned a worldwide gross of over $1 billion, making it the fourth highest-grossing film of 2016 and the 37th highest-grossing film of all time. The film was chosen by the American Film Institute as one of the top ten films of 2016.^[165]