Chandrasekaran Lab

Publications

viswanathan chandrasekaran - Search Results - PubMed

2023

Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT - Nature Structural & Molecular BiologyUsing cryo-EM, the authors show that the mammalian CCR4–NOT complex specifically recognizes stalled translating ribosomes similar to the yeast complex, locks them in a translation-incompetent state and coordinates their ubiquitylation, highlighting its central role in linking translation to mRNA stability.

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2022

Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targetingThe nascent polypeptide–associated complex regulates signal recognition particle function and controls endoplasmic reticulum targeting.

2021

Visualizing formation of the active site in the mitochondrial ribosomeGTPBP7, NSUN4, and MTERF4 facilitate maturation of the peptidyl transferase center of the mitochondrial ribosome.

2020

Elongational stalling activates mitoribosome-associated quality controlElongationally stalled mitochondrial ribosomes are rescued by a mitoribosome-associated quality control pathway.

TTC5 mediates autoregulation of tubulin via mRNA degradation

2019

Mechanism of ribosome stalling during translation of a poly(A) tail - Nature Structural & Molecular BiologyBiochemical and structural analysis demonstrate that simultaneous detection of poly-lysine in the exit tunnel and poly(A) in the decoding center allows ribosomes to detect aberrant mRNAs, stall elongation and trigger downstream quality control pathways.

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2018

linkinghub.elsevier.com/retrieve/pii/S1097-2765(18)30697-X

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

PhD Work

2016

Primate TRIM5 proteins form hexagonal nets on HIV-1 capsidsTo protect mammals against retroviral infections, TRIM5 restriction factors recognize viral capsids by forming complementary hexagonal nets that can adapt to the patterns of capsid protein subunits on the viral capsid surface.

2014

PNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.

2011

PNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.

2008

Biochemical Characterization of a Recombinant TRIM5α Protein That Restricts Human Immunodeficiency Virus Type 1 Replication | Journal of Virology ABSTRACT The rhesus monkey intrinsic immunity factor TRIM5αrh recognizes incoming capsids from a variety of retroviruses, including human immunodeficiency virus type 1 (HIV-1) and equine infectious anemia virus (EIAV), and inhibits the accumulation of ...

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