Parkinson's disease (PD), the second-most prevalent neurodegenerative disorder in the United States after Alzheimer's disease, primarily affects individuals aged 60 and older, although 5 to 10 percent receive a diagnosis before reaching 50.

Transcranial Direct Current Stimulation (tDCS) has garnered attention in recent studies as a potential therapeutic intervention for depression in individuals afflicted with Parkinson's Disease (PD). A burgeoning body of research has explored the efficacy of tDCS in ameliorating depressive symptoms in this specific patient population. 

Our research team is investigating the best way to reduce the symptoms of depression for people living with PD without medication. That's why we are studying tDCS as a safe, effective way to provide symptom improvement.

Transcranial direct current stimulation, or tDCS for short, is like a gentle way to give the brain a tiny boost of electricity. Imagine a small battery that sends a soft, safe flow of electric current through special pads placed on the head. This little bit of electricity doesn't hurt; instead, it can help the brain work a bit better. Doctors and scientists use tDCS to help people think clearer or improve their mood, and it's even being studied to see if it can help with learning and memory. It's a cool way scientists are trying to help our brains!

• Parkinson's disease (PD) is primarily known for its motor symptoms, but it can also manifest various psychological symptoms. Non-motor symptoms in patients with Parkinson's disease (PD) are often poorly recognized, significantly impair quality of life and cause severe disability. Currently, there is limited evidence to guide treatment of associated psychiatric and cognitive problems(2). The most common psychological symptoms associated with Parkinson's disease include:

• Depression: Individuals with PD often experience depressive symptoms, including persistent sadness, loss of interest or pleasure in activities, and changes in appetite and sleep patterns.

• Apathy: Apathy is a common psychological symptom in PD, characterized by a lack of motivation, interest, or enthusiasm. It can contribute to decreased engagement in daily activities.

• Anxiety: Anxiety disorders are prevalent among individuals with PD, leading to excessive worry, restlessness, and feelings of tension. Anxiety can exacerbate motor symptoms and impact overall well-being.

• Cognitive Impairment: PD can be associated with cognitive decline, including difficulties with memory, attention, and executive functions. In some cases, this may progress to dementia known as Parkinson's disease dementia (PDD).

• This study is approved by the University of South Alabama Internal Review Board (IRB) and is an approved, registered clinical trial with with National Institutes of Health.

• tDCS has been used with thousands of patients all over the world, and is generally recognized as safe. Some possible side effects are tingling of the scalp and irritation of the skin. These are rare, and the study team would always have your safety and comfort as our top priority.

This study is run by a team of licensed professionals and experienced researchers.

Principal Investigators: John Shelley-Tremblay, Ph.D.

University of South Alabama

Chair, Department of Psychology

 251-460-6883, jstremblay@southalabama.edu

Benjamin Hill Ph.D., Licensed Clinical Neuropsychologist

Professor, University of South Alabama

Department of Psychology

 251-460-6371, bdhill@southalabama.edu

Andrew Romeo, M.D., Board Certified Neurosurgeon

USA College of Medicine

Department of Neurosurgery

aromeo@health.southalabama.edu

Olivier Darbin, Ph.D.

USA College of Medicine

Researcher, Department of Neurosurgery

odarbin@southalabama.edu