Research

Polycystic kidney disease (PKD) is a common genetic disorder and is manifested by defects in renal epithelial cells. PKD is a systemic disorder which is characterized by cysts in the kidney, liver and pancreas. Multiple mechanisms contribute to PKD, including increased proliferation and apoptosis, also dedifferentiation and loss of epithelial polarity. 

In end-stage renal disease (ESRD) of ADPKD, many patients depend on hemodialysis to attenuate renal failure of transplantation, but thus far, no suitable treatment has been developed.

Our Research

● Screening of Therapeutic Targets for PKD

Identification of mechanism of renal failure which is related to cyst formation

Research of functional genomics of kidney disease using gene targeted mouse model

Investigation of gene network mapping related to renal cyst formation

Confirmation of effect of new therapeutic targets for PKD

● Study of Epigenetic Regulation of PKD

Investigation of new miNAs related to renal cyst

Genome-wide profiling of DNA methylation patters of cystogenesis-associated genes in ADPKD

● Identification of Cilia Function in PKD

Research of cilia assembly or disassembly mechanism in PKD

Identification of cystogenesis mechanism in mouse model with defective cilia

Breast Cancer is the most frequently diagnosed cancers in women worldwide. Classically, breast cancer is hormone dependent tumor in presence of estrogen which interacts with its receptor. Approximately 70% of breast cancer patients were classified to estrogen receptora (ERa

-positive so diverse treatments focused on targeting ERa

Tamoxifen, antagonist of the ER, is broadly used in adjuvant treatment for ERa-positive breast cancer patients. Unfortunately, resistance to ERa

-targeted therapy is main barrier in spite of advanced endocrine therapy in breast cancer. In various types of endocrine therapy resistance, the reduced estrogen dependence due to loss of ERa is one of the important reasons.

Our Research

Research of Breast Cancer & Epigenetics

Epigenetic regulatory mechanism of breast cancer oncogene

Genome-wide profiling of DNA methylation patterns of breast cancer.

Identification of endocrine resistance in breast cancer

Study of Breast Cancer Stemness & miRNAs

Finding of new miRNAs related to breast cancer

Validation of new miRNA functions in xenograft model

Identification of recovery mechanism of chemo-resistant

Polycystic kidney disease (PKD) is a common genetic disorder and is manifested by defects in renal epithelial cells. PKD is a systemic disorder which is characterized by cysts in the kidney, liver and pancreas. Multiple mechanisms contribute to PKD, including increased proliferation and apoptosis, also dedifferentiation and loss of epithelial polarity. 

In end-stage renal disease (ESRD) of ADPKD, many patients depend on hemodialysis to attenuate renal failure of transplantation, but thus far, no suitable treatment has been developed.

Our Research

● Screening of Therapeutic Targets for PKD

Identification of mechanism of renal failure which is related to cyst formation

Research of functional genomics of kidney disease using gene targeted mouse model

Investigation of gene network mapping related to renal cyst formation

Confirmation of effect of new therapeutic targets for PKD