Publications

2025

Kim DH, Lee YC, Jin C, Kang SM, Kang SJ, Kang HS, Lee BJ. Structural and Functional Insight Into YefM-YoeB Complex of Toxin-Antitoxin System From Streptococcus pneumoniae. J Cell Biochem. 2025 Jan;126(1):e30672. doi: 10.1002/jcb.30672. Epub 2024 Nov 12. PMID: 39530329.

2024

Jin C, Jeon CH, Kim HW, Kang JM, Choi Y, Kang SM, Lee HH, Kim DH*, Han BW*, Lee BJ*. Structural insight into the distinct regulatory mechanism of the HEPN-MNT toxin-antitoxin system in Legionella pneumophila. Nat Commun. 2024 Nov 24;15(1):10188. doi: 10.1038/s41467-024-54551-0. PMID: 39582057; PMCID: PMC11586414.

Kang SM, Kang HS, Chung WH, Kang KT, Kim DH. Structural Perspectives on Metal Dependent Roles of Ferric Uptake Regulator. Biomolecules. 2024 Aug 9;14(8):981. doi: 10.3390/biom14080981. PMID: 39199369; PMCID: PMC11353095.

Tran DVH, Luong HX, Kim DH, Lee BJ, Kim YW. Lysine-homologue substitution: Impact on antimicrobial activity and proteolytic stability of cationic stapled heptapeptides. Bioorg Med Chem. 2024 May 15;106:117735. doi: 10.1016/j.bmc.2024.117735. Epub 2024 Apr 25. PMID: 38714021.

Jin C‡, Kang SM‡, Kim DH‡, Lee Y, Lee BJ. Discovery of Antimicrobial Agents Based on Structural and Functional Study of the Klebsiella pneumoniae MazEF Toxin-Antitoxin System. Antibiotics (Basel). 2024 Apr 26;13(5):398. doi: 10.3390/antibiotics13050398. PMID: 38786127; PMCID: PMC11117207.

Kang SJ‡, Kim DH‡, Lee BJ. Metallo-β-lactamase inhibitors: A continuing challenge for combating antibiotic resistance. Biophys Chem. 2024 Jun;309:107228. doi: 10.1016/j.bpc.2024.107228. Epub 2024 Mar 25. PMID: 38552402.

2023

Kim DH‡, Na Y‡, Chang H, Boo JH, Kang SM, Jin C, Kang SJ, Lee SY, Lee BJ. Domain swapping of the C-terminal helix promotes the dimerization of a novel ribonuclease protein from Mycobacterium tuberculosis. Protein Sci. 2023 Jun;32(6):e4644. doi: 10.1002/pro.4644. PMID: 37070717; PMCID: PMC10182728.

2022

Koo JS, Kang SM, Jung WM, Kim DH, Lee BJ. The Haemophilus influenzae HipBA toxin-antitoxin system adopts an unusual three-component regulatory mechanism. IUCrJ. 2022 Jul 29;9(Pt 5):625-631. doi: 10.1107/S205225252200687X. PMID: 36071804; PMCID: PMC9438503.

Kim DH, Kang SM, Baek SM, Yoon HJ, Jang DM, Kim HS, Lee SJ, Lee BJ. Role of PemI in the Staphylococcus aureus PemIK toxin-antitoxin complex: PemI controls PemK by acting as a PemK loop mimic. Nucleic Acids Res. 2022 Feb 28;50(4):2319-2333. doi: 10.1093/nar/gkab1288. PMID: 35141752.

2021

Kang SM, Kim DH. A Structural Approach into Drug Discovery Based on Autophagy. Life (Basel). 2021 Jun 4;11(6):526. doi: 10.3390/life11060526. PMID: 34199860; PMCID: PMC8226661. 

Jin C*, Kang SM*, Kim DH*, Lee BJ. Structural and functional analysis of the Klebsiella pneumoniae MazEF toxin-antitoxin system. IUCrJ. 2021 Mar 5;8(Pt 3):362-371. doi: 10.1107/S2052252521000452. PMID: 33953923; PMCID: PMC8086154. 

Kang SM, Moon H, Han SW, Kim BW, Kim DH, Kim BM, Lee BJ. Toxin-Activating Stapled Peptides Discovered by Structural Analysis Were Identified as New Therapeutic Candidates That Trigger Antibacterial Activity against Mycobacterium tuberculosisin the Mycobacterium smegmatis Model. Microorganisms. 2021 Mar 10;9(3):568. doi: 10.3390/microorganisms9030568. PMID: 33801872; PMCID: PMC8000039.

Kang SM, Jin C, Kim DH, Park SJ, Han SW, Lee BJ. Structure-based design of peptides that trigger Streptococcus pneumoniae cell death. FEBS J. 2021 Mar;288(5):1546-1564. doi: 10.1111/febs.15514. Epub 2020 Aug 31. PMID: 32770723; PMCID: PMC7984235.

2020

Kang SM‡, Jin C‡, Kim DH‡, Lee Y, Lee BJ. Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin-Antitoxin System, Including the Development of an Inhibitor That Activates VapC. J Med Chem. 2020 Nov 25;63(22):13669-13679. doi: 10.1021/acs.jmedchem.0c01118. Epub 2020 Nov 4. PMID: 33146528.

Kang SM, Moon H, Han SW, Kim DH, Kim BM, Lee BJ. Structure-Based De NovoDesign of Mycobacterium TuberculosisVapC-Activating Stapled Peptides. ACS Chem Biol. 2020 Sep 18;15(9):2493-2498. doi: 10.1021/acschembio.0c00492. Epub 2020 Sep 9. PMID: 32840352.

Kang SM, Koo JS, Kim CM, Kim DH, Lee BJ. mRNA Interferase Bacillus cereus BC0266 Shows MazF-Like Characteristics Through Structural and Functional Study. Toxins (Basel). 2020 Jun 8;12(6):380. doi: 10.3390/toxins12060380. PMID: 32521689; PMCID: PMC7354611.

Park JY, Kim HJ, Pathak C, Yoon HJ, Kim DH, Park SJ, Lee BJ. Induced DNA bending by unique dimerization of HigA antitoxin. IUCrJ. 2020 Jun 26;7(Pt 4):748-760. doi: 10.1107/S2052252520006466. PMID: 32695421; PMCID: PMC7340258.

2019

Kang SM‡, Kim DH‡, Jin C, Ahn HC, Lee BJ. The crystal structure of AcrR from Mycobacterium tuberculosis reveals a one-component transcriptional regulation mechanism. FEBS Open Bio. 2019 Oct;9(10):1713-1725. doi: 10.1002/2211-5463.12710. Epub 2019 Aug 20. PMID: 31369208; PMCID: PMC6768106.

2018

Kang SM‡, Kim DH‡, Jin C, Lee BJ. A Systematic Overview of Type II and III Toxin-Antitoxin Systems with a Focus on Druggability. Toxins (Basel). 2018 Dec 4;10(12):515. doi: 10.3390/toxins10120515. PMID: 30518070; PMCID: PMC6315513.

Luong HX, Kim DH, Lee BJ, Kim YW. Effects of lysine-to-arginine substitution on antimicrobial activity of cationic stapled heptapeptides. Arch Pharm Res. 2018 Nov;41(11):1092-1097. doi: 10.1007/s12272-018-1084-5. Epub 2018 Oct 25. PMID: 30361948.

Kim DH, Kang SM, Park SJ, Jin C, Yoon HJ, Lee BJ. Functional insights into the Streptococcus pneumoniae HicBA toxin-antitoxin system based on a structural study. Nucleic Acids Res. 2018 Jul 6;46(12):6371-6386. doi: 10.1093/nar/gky469. PMID: 29878152; PMCID: PMC6159526.

Jin H, Kim MG, Ko SB, Kim DH, Lee BJ, Macgregor RB Jr, Shim G, Oh YK. Stemmed DNA nanostructure for the selective delivery of therapeutics. Nanoscale. 2018 Apr 26;10(16):7511-7518. doi: 10.1039/c7nr08558c. PMID: 29637946.

2017

Luong HX, Kim DH, Lee BJ, Kim YW. Antimicrobial activity and stability of stapled helices of polybia-MP1. Arch Pharm Res. 2017 Dec;40(12):1414-1419. doi: 10.1007/s12272-017-0963-5. Epub 2017 Oct 26. PMID: 29075946.

Kim DH, Kang SM, Lee BJ. Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery. Molecules. 2017 Aug 31;22(9):1447. doi: 10.3390/molecules22091447. PMID: 28858250; PMCID: PMC6151718.

Kang SM, Kim DH, Lee KY, Park SJ, Yoon HJ, Lee SJ, Im H, Lee BJ. Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides. Nucleic Acids Res. 2017 Aug 21;45(14):8564-8580. doi: 10.1093/nar/gkx489. PMID: 28575388; PMCID: PMC5737657.

Luong HX, Kim DH, Mai NT, Lee BJ, Kim YW. Mono-substitution effects on antimicrobial activity of stapled heptapeptides. Arch Pharm Res. 2017 Jun;40(6):713-719. doi: 10.1007/s12272-017-0922-1. Epub 2017 May 25. PMID: 28547390.

Kim DH, Kang SJ, Lee KY, Jang SB, Kang SM, Lee BJ. Structure and dynamics study of translation initiation factor 1 from Staphylococcus aureus suggests its RNA binding mode. Biochim Biophys Acta Proteins Proteom. 2017 Jan;1865(1):65-75. doi: 10.1016/j.bbapap.2016.10.009. Epub 2016 Oct 23. PMID: 27784646.

~2016

Luong HX, Kim DH, Lee BJ, Kim YW. Antimicrobial and hemolytic activity of stapled heptapeptide dimers. Bull Korean Chem Soc. 2016; 37(8):1199-1203. 

Dinh TT, Kim DH, Nguyen TQ, Lee BJ, Kim YW. (2015). N-capping effects of stapled heptapeptides on antimicrobial and hemolytic activities. Bull Korean Chem Soc. 2015;36(10):2511-2515.

Dinh TT, Kim DH, Luong HX, Lee BJ, Kim YW. Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. doi: 10.1016/j.bmcl.2015.06.053. Epub 2015 Jun 19. PMID: 26235946.

Kim DH, Im H, Jee JG, Jang SB, Yoon HJ, Kwon AR, Kang SM, Lee BJ. β-Arm flexibility of HU from Staphylococcus aureus dictates the DNA-binding and recognition mechanism. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3273-89. doi: 10.1107/S1399004714023931. Epub 2014 Nov 28. PMID: 25478845.

Pham TK, Kim DH, Lee BJ, Kim YW. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. doi: 10.1016/j.bmcl.2013.10.031. Epub 2013 Oct 26. PMID: 24211019.

Kang SJ, Kim DH, Lee BJ. NMR study on small proteins from Helicobacter pylori for antibiotic target discovery: a review. Molecules. 2013 Oct 30;18(11):13410-24. doi: 10.3390/molecules181113410. PMID: 24177697; PMCID: PMC6269979.

Kim DH, Jang SB, Lee BJ. Backbone 1H, 15N, and 13C resonance assignments and secondary structure prediction of SAV2228 (translation initiation factor-1) from Staphylococcus aureus. J Kor Magn Reson Soc. 2012;16(2):162-171.

Jung O, Choi S, Jang SB, Lee SA, Lim ST, Choi YJ, Kim HJ, Kim DH, Kwak TK, Kim H, Kang M, Lee MS, Park SY, Ryu J, Jeong D, Cheong HK, Kim HJ, Park KH, Lee BJ, Schlaepfer DD, Lee JW. Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci. 2012 Dec 15;125(Pt 24):5960-73. doi: 10.1242/jcs.100586. Epub 2012 Oct 17. PMID: 23077174; PMCID: PMC4074290. 

Kang SJ, Kim DH, Mishig-Ochir T, Lee BJ. Antimicrobial peptides: their physicochemical properties and therapeutic application. Arch Pharm Res. 2012 Mar;35(3):409-13. doi: 10.1007/s12272-012-0302-9. Epub 2012 Apr 5. PMID: 22477186.

Jang SB, Ma C, Pathak CC, Kim DH, Lee BJ. 1H, 15N and 13C resonance assignment and secondary structure prediction of ss-DNA binding protein 12RNP2 precursor, HP0827 from Helicobacter pylori. J Kor Magn Reson Soc. 2011;15(1):69-79.