Publications

Selected research publications

2024

1. Govindaraju G, Rajavelu A. Reading the Epitranscriptome of human malaria parasite. Biomed J. 2024 Feb 3:100703. In press.

2023

2. Jabeena CA, Rajavelu A*. Histone globular domain epigenetic modifications: The regulators of chromatin dynamics in malaria parasite. ChemBioChem. 2023 Dec 11: e202300569.

3. Vini R, Lekshmi A, Ravindran S, Thulaseedharan JV, Sujathan K, Rajavelu A*, Sreeja S. 27-Hydroxycholesterol represses G9a expression via oestrogen receptor alpha in breast cancer. J Cell Mol Med. 2023 Aug 23 (In press). *Corresponding author

4. Karthika CL, Venugopal V, Sreelakshmi BJ, Krithika S, Thomas JM, Abraham M, Kartha CC, Rajavelu A, Sumi S. Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations. Cell Mol Biol Lett. 2023 Mar 18;28(1):22. 

5. Kunert S, Emperle M, Adam S, Bräcker J, Brockmeyer J, Rajavelu A, Jeltsch A. The R736H cancer mutation in DNMT3A modulates the properties of the FF-subunit interface. Biochimie. 2023 May;208:66-74 

2022

6. Thomas JM, Sasankan D, Abraham M, Surendran S, Kartha CC*, Rajavelu A*. DNA methylation signatures on vascular differentiation genes are aberrant in vessels of human cerebral arteriovenous malformation nidus. Clinical Epigenetics. 2022, Oct 13;14(1):127. *Corresponding author.

7. Sethumadhavan DV, Tiburcio M, Kanyal A, Jabeena CA, Govindaraju G, Karmodiya K, Rajavelu A*. Chromodomain protein interacts with H3K9me3 and controls RBC rosette formation by regulating the expression of a subset of RIFINs in the malaria parasite. J Mol Biol, 2022 Apr 20, 434 (12); 167601. (Cover page article).

8. Ravindran V, Rajavelu A*, Sreeharshan S*. 27-hydroxycholesterol, the estrogen receptor modulator alters DNA methylation in breast cancer. Frontiers in Endocrinology. 2022 Mar 10, 13: 783823. *Corresponding authors.

2021

9. Gayathri G, Chavali S, Rajavelu A*. Plasmodium falciparum YTH2 domain binds to m6A containing mRNA and regulates translation. mBio. 2021 Dec 21, 12(6): e0136721. *Corresponding author.

10. Devadathan VS, CA Jabeena, Govindaraju G, Aparna S, Rajavelu A*. The severity of SARS-CoV-2 infection is dictated by host factors? Epigenetic perspectives. Current Research in Microbial Sciences, 2021 Dec 2; 100079. *Corresponding author.

11. Mukesh RK, Kalam AA, Nag J, Jaikumar VS, Kunnakkadan U, Suma NM, Rajavelu A, Johnson JB. Chandipura virus induces cell death in cancer cell lines of human origin and promotes tumor regression in vivo. Molecular Therapy – Oncolytics, 2021, Dec 17; Vol 23; 254 -265.

12. Devadathan VS, Govindaraju G, CA Jabeena, Rajavelu A*. The SET2 domain is allosterically regulated by its PHD domain to methylate at H3K36 in Plasmodium falciparum. BBA Gene Regulatory Mechanisms, 2021 oct; 1865(10): 194744. *Corresponding author.

13. Khan MIK, Charles RCM, Ramachandran R, Gupta S, Govindaraju G, Mishra R, Rajavelu A, Coumar MS, Chavali S, Dhayalan A. The ribosomal protein eL21 interacts with the protein lysine methyltransferase SMYD2 and regulates its steady state levels. Biochim Biophys Acta Mol Cell Res. 2021 Aug;1868(9):119079.

14. Jabeena CA, Govindaraju G, Devadathan VS, Soundararajan G, Jaleel A, Dhakshmi S, Rajavelu A*. Dynamic association of the H3K64 trimethylation mark on the genes encoding exported proteins in Plasmodium falciparum. J Biol Chem. 2021 Apr 8; 296:100614. *Corresponding author. 

15. Thomas JM, Surendran S, Abraham M, Rajavelu A*, Kartha CC*. Aberrant regulation of retinoic acid signaling genes in cerebral Arterio Venous Malformation nidus and neighbouring astrocytes. Journal of Neuroinflammation. 2021, Mar 1; 18(1): 61. *Corresponding author.

16. Verma M, Khan MI, Chakrapani B, Awasthi S, Mahesh A, Govindaraju G, Chavali PL, Rajavelu A, Chavali S, Dhayalan A. PRMT3 interacts with ALDH1A1 and regulates gene expression by inhibiting retinoic acid. Communications Biology, 2021 Jan 25; 4 (1): 109.

2020

17.  Chakrapani B, Khan MI, Verma M, Awasthi S, Govindaraju G, Mahesh A, Rajavelu A, Chavali S, Dhayalan A. The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions. Life Science Alliance, 2020 Dec 29; 4(3): e202000699.

18.  12.  Govindaraju G, Varma RSK, Jabeena CA, Devadathan VS, Chavali S, Rajavelu A*. N6-Adenosine methylation, a regulatory mark on mRNA is recognized by YTH domain protein in human malaria parasite P. falciparum. Epigenetics & Chromatin, 2020, 13 (1), 33. *Corresponding author.

19.  13.  Mahesh A, Khan MI, Govindaraju G, Verma M, Awasthi S, Chavali PL, Chavali S, Rajavelu A*, Dhayalan A*. SET7/9 interacts and methylates the ribosomal protein, eL42 and regulates protein synthesis. BBA – Molecular Cell Research. 2020 Feb;1867(2):118611. *Corresponding authors.

2019

20.  14.  Jabeena CA, Rajavelu A*. Epigenetic players of chromatin structure regulation in Plasmodium falciparum. ChemBioChem. 2019, 15, 20(10). *Corresponding author.  

2018

21.  15.  Awasthi S, Verma M, Mahes A, Khan MI, Govindaraju G, Rajavelu A, Chaval PL, Chavali S, Dhayalan A. DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA. Nucl Acid Res. 2018, Mar 30. 46(12):6304-6317.

22.  16.  Rajavelu A, Lungu C, Emperle M, Dukatz M, Bröhm A, Broche J, Hanelt I, Parsa E,  Schiffers S,  Karnik R, Meissner A,  Carell T,  Rathert P, Jurkowska RZ, Jeltsch A. Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucl Acid Res. 2018 Sep 28; 46 (17):9044-9056.

23.  17.  Emperle M, Dukatz M, Kunert S, Holzer K, Rajavelu A, Jurkowska RZ, Jeltsch A. The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes. Sci Rep. 2018 Sep 5;8(1):13242. 

24.  18.  Emperle M, Rajavelu A, Kunert S, Arimondo PB, Reinhardt R, Jurkowska RZ, Jeltsch A. The DNMT3A R882H mutant displays altered flanking sequence preferences. Nucl Acid Res. 2018 Apr 6;46(6):3130-3139.

25.  19.  Thomas JM, Surendran S, Abraham M, Rajavelu A*, Kartha CC*. Gene expression analysis of nidus of cerebral arteriovenous malformations reveals vascular structures with deficient differentiation. Plos One, 2018, 13; 13 (6). *Corresponding authors.

2017

26.  20.  Govindaraju G, Jabeena CA, Sethumadhavan DV, Rajaram N, Rajavelu A*. DNA methyltransferase homologue TRDMT1 in Plasmodium falciparum specifically methylates endogenous aspartic acid tRNA. BBA – Gene Regulatory Mechanisms. 2017 Oct; 1860(10): 1047-1057. *Corresponding author.

27.  21.  Verma M, Chandar R, Chakrapani B, Coumar MS, Govindaraju G, Rajavelu R, Chavali S, Dhayalan A. PRMT7 interacts with ASS1 and citrullinemia mutations disrupt the Interaction. J Mol Biol. 2017, 429 (15): 2278 – 2289.

2016

28.  22.  Thomas JM, Surendran S, Abraham M, Rajavelu A*, Kartha CC*. Genetic and Epigenetic mechanisms in the development of arteriovenous malformation in the brain. Clinical Epigenetics. 2016, 8 (1), 78. *Corresponding authors.