Research

A major challenge in bone tissue engineering is the limited oxygen supply within large or poorly vascularized tissue constructs. Hypoxia can impair cell survival, proliferation, osteogenic differentiation, and ultimately hinder successful bone regeneration. Our research focuses on the development of oxygen-generating biomaterials that provide sustained oxygen release to engineered tissues during the critical early stages of healing. By alleviating oxygen deficiency, these advanced biomaterials enhance cell viability, promote vascularization, and support new bone formation. This strategy offers a promising approach to improving the effectiveness of bone grafts and tissue-engineered constructs, particularly for large bone defects where rapid vascularization remains a significant challenge.