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Zimei Bu, PhD
卜子梅
Professor and Laboratory Director
Department of Chemistry
Marshak Science Building 1336
City College of New York
160 Convent Avenue
New York, NY 10031
zbu at ccny dot cuny dot edu
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Nanoscale protein dynamics: A new frontier for neutron spin echo spectroscopy
Neutron spin echo spectroscopy (NSE) is the only experimental technique that can determine protein motion on nano length and time scales. Such motions have long been hypothesized to be the most significant modes for protein function. We have developed a theoretical framework that allows one to interpret the NSE data. Our theoretical framework uses simple concepts from nonequilibrium statistical mechanics, and does not require elaborate molecular dynamics simulations, complex fits to rotational motion, or elastic network models. In combination with our experimental methodology of selective deuterium labeling, our work clears significant hurdles to the understanding of this very important problem.
cover article A brief introduction to
neutron spin echo spectroscopy
and protein dynamics
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Z. Bu, J. Cook, D.J.E. Callaway. J. Mol. Biol. (2001) 312, 865-873.
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Jianquan Li, David J.E. Callaway,and Zimei Bu. J Mol Biol. Sep 11, 2009; 392(1): 166?180.
DOI: 10.1016/j.jmb.2009.07.005
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Another recent publication and HERE! and HERE!
Structure-specific DNA induced conformational changes in Taq polymerase revealed by small angle neutron scattering.
D. L. Ho, W. M. Byrnes, W. P. Ma, Y. Shi, D.J.E. Callaway (co-corresponding), Zimei Bu. J. Biol. Chem., 2004 Sep 10;279(37):39146-54.
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Bhattacharya S, Dai Z, Li J, Baxter S, D.J.E. Callaway (co-corresponding), Cowburn D, Bu Z. J Biol Chem. 2010 Mar 26;285(13):9981-94.
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Li J, Dai Z, Jana D, Callaway DJ, Bu Z. J Biol Chem. 2005 Nov 11;280(45):37634-43.
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Callaway DJE, Bu Z. Biophys Rev. 2015 Jun;7(2):165-174.
Biophysical Reviews ISSN 1867-2450
DOI: 10.1007/s12551-015-0162-x
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Callaway DJE, Bu Z. Methods in Enzymology.
Isotope Labeling of Biomolecules - Applications. Volume 566, 2016, Pages 253 -270.
ISBN: 978-0-12-803049-3
DOI: 10.1016/bs.mie.2015.05.011
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Jayasundar JJ, Ju JH, He L, Liu D, Meilleur F, Zhao J, Callaway DJ, Bu Z. J Biol Chem. 2012 Oct 26;287(44):37119-33.
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Li J, Poulikakos PI, Dai Z, Testa JR, Callaway DJ, Bu Z. J Biol Chem. 2007 Sep 14;282(37):27086-99
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article Callaway DJE, Bu Z. Current Opinion in Structural Biology 2017,42:1-5.
DOI: 10.1016/j.sbi.2016.10.001
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Xiaodong Chen, Jahan Ali Khajeh, Jeong Ho Ju, Yogesh K. Gupta, Christopher B. Stanley, Changwoo Do, William T. Heller, Aneel K. Aggarwal,
David J. E. Callaway and Zimei Bu
J Biol Chem. 2015 Mar 6;290(10):6639-52
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Assembling amyloid fibrils from designed structures containing a significant Alzheimer beta-peptide fragment.
L.O. Tjernberg, A. Tjernberg, N. Bark, Y. Shi, B. P. Ruzsicska, Z. Bu, J. Thyberg, D.J.E. Callaway.
Biochem. J. (2002) 366, 343-351.
Another recent publication HERE! and HERE!
Shi Y, Stouten PF, Pillalamarri N, Barile L, Rosal RV, Teichberg S, Bu Z, D.J.E. Callaway.
Quantitative determination of the topological propensities of amyloidogenic peptides.
Biophys Chem. 120 (2006), 55-61.
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