Yang Z‡, LaRivere M ‡, Ko J ‡, Till J, Christensen T, Yee S, Black T, Tien K, Bhagwat N, Lin A, Adallah A, O’Hara MH, Vollmer CM, Katona BW, Stanger BZ, Issadore D, Carpenter EL, A multi-analyte, liquid biopsy approach for diagnosing and staging of pancreatic adenocarcinoma. Clinical Cancer Research, 2020
Highlighted in U.S.News, Science EurekAlert, Penn Medicine News, ANI News
This work has initialized clinical collaboration with UnitedHealth Group on lung cancer screening involving > 500 patients
This work initiated alpha-type commercialized products for Point-of-Care start-up ChipDiagnostics Inc. (raised $8,000,000 funding so far)
2. Yang Z‡, Atiyas Y‡, Siedlik M J, Shen H, Wu J, Beard K, Sonar G, Dolls J P, Smith D H, Eberwine J H, Meaney DF, Issadore D, Ultrasensitive Single Extracellular Vesicle Detection Using High Throughput Droplet Digital Enzyme-Linked Immunosobrbent Assay, Nano Letter, 2022
This work has been awarded for Penn Health Tech Pioneer Award ($50,000)
This work has made the finalist of 2021 Nokia Bell Labs Prize for Innovators (6 out of 108 projects worldwide)
3. Beard K‡, Yang Z‡, Haber M, Flamholz M, Diaz-Arrastia R, Sandsmark D, Meaney DF, Issadore D, Extracellular vesicles and plasma as distinct biomarker reservoirs for mild traumatic brain injury, Brain Communication, 2021
4. Iyer V‡, Yang Z‡, Ko J‡, Weisslleder R, Issadore D, Advancing microfluidic diagnostic chips for clinical use, Lab on a Chip, 2022
5. Lu L‡, Yang Z‡, Mecham K, Cvetkovic C, Corbin E, Guardado AV, Xue M, Yin L, Boroumand J, Pakeltis G, Yu KJ, Chanda D, Bashir R, Gereau RW, Sheng X, Rogers JA, Biodegradable monocrystalline silicon photovoltaic microcells as power supplies for transient biomedical implants. Advanced Energy Materials, 2018
6. Hui F‡, Yu KJ‡, Closchat C‡, Yang Z, Song E, Chiang CH, Zhao J, Won SM, Trumpis M, Zhong Y, Han SW, Xue Y, Xu D, Choi SW, Cauwenberghs G, Kay M, Huang Y, Viventi J, Efimov IR, Rogers JA. Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology. Nature Biomedical Engineering, 2017
Highlighted in Nature Biomedical Engineering, IEEE Spectrum, MRS Bulletin, Med Device Online
7. Siedlik MJ, Yang Z, Kadam PS, Eberwine J, Issadore D, Micro and Nano devices for studying subcellular biology, Small, 2021
8. Muraoka S, DeLeo, AM, Yang Z, Tatebe H, Yukawa K, Ikezu S, Tokuda T, Issadore D, Stern R, Ikezu T, Proteomic characterization of plasma-derived extracellular vesicles from former National Football League players at risk for chronic traumatic encephalopathy, Aging and Disease, 2020.
9. Muraoka S, DeLeo AM, Sethi MK, Takamatsu KY, Yang Z, Ko J, Hogan J, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantia S, Gendelman HE, Issadore D, Zaia J, Ikezu T, Proteomic profiling and biological characterization of extracellular vesicles isolated from human Alzheimer’s disease brain tissues, Alzheimer’s and Dementia, 2020.
10. Ko J, Hemphill M, Yang Z, Beard K, Sewell E, Shallcross J, Schweizer M, Sandsmark DK, Diaz-Arrastia R, Kim J, Meaney D, Issadore D, Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics. Journal of Neurotrauma, 2019.
11. Ko J, Hemphill M, Yang Z, Sewell E, Sandsmark DK, Haber M, Fisher SA, Torre EA, Svane KC, Omelchenko A, Firestein BL, Diaz-Arrestia R, Kim J, Meaney DF, Issadore D. Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles, Lab on a Chip, 2018
12. Chang JK, Emon MA B, Li CS, Yang Q, Chang HP, Yang Z, Wu CI, Said MT Rogers JA. Cytotoxicity and in vitro degradation kinetics of fundry-compatible semiconductor nanomembranes and electronic microcomponents. ACS Nano, 2018
13. Hui F, Zhao J, Yu KJ, Song E, Farimani AB, Chiang CH, Xin J, Xue Y, Xu D, Du W, Seo KJ, Zhong Y, Yang Z, Won SM, Fang G, Choi SW, Chaudhuri S, Huang Y, Alam MA, Viventi J, Aluru NR, Rogers JA. Ultrathin, transferred layers of thermally grown silicon dioxide as biofluid barriers for biointegrated flexible electronic systems. Proceedings of the National Academy of Sciences, 2016
14. Xu L, Gutbrod SR, Ma Y, Petrossians A, Liu Y, Webb RC, Fan JA, Yang Z, Xu R, Whalen JJ, Weiland JD, Huang Y, Efimov IR, Rogers JA. Materials and Fractal Designs for 3D Multifunctional Integumentary Membranes with Capabilities in Cardiac Electrotherapy. Advanced Materials, 2015
Featured on Journal Front Cover