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Yuzo Takayama

National Institute of Advanced Industrial Science and Technology (AIST),
Biotechnology Research Institute for Drug Discovery,
Biotherapeutic Research Group,
Senior Researcher 
Central 5-41, Higashi 1-1-1, Tsukuba, Ibaraki 305-8565, Japan

Tel:+81-29-861-2620 Fax:+81-29-861-3000
E-mail: yuzo-takayama[at mark]aist.go.jp

Research Position 

Education 

Professional Soceity 


Awards 


Reserch Interests 

  • Construction of stem cell-derived 3-dimensional tissue structures using microfabrication techniques (2013.4 -)
  • Patterning cultured neuronal networks in microfluidic devices (2010.4 -)
  • Evaluation and control of cell differentiation processes using microfabrication techniques (2007.4 - )
  • Plasticity in neuronal networks (2004.4 - )

 

Journal Papers 

  24: Akira Wagatsuma, Yuzo Takayama, Takayuki Hoshino, Masataka Shiozuka, Shigeru Yamada, 
        Ryoichi Matsuda, Kunihiko Mabuchi, "Pharmacological targeting of HSP90 with 17-AAG 
       Molecular and Cellular Biochemistry, in press (2017). 

  23: Yohei Kondo, Yuichiro Yada, Tatsuya Haga, Yuzo Takayama, Takuya Isomura, Yasuhiko Jimbo, 
       Osamu Fukayama, Takayuki Hoshino*, Kunihiko Mabuchi, "Temporal relation between neural 
       electrode array", Biochemical and Biophysical Research Communications, vol. 486, 
       pp. 539-544, (2017).

  22: Yuzo Takayama, Tamami Wakabayashi, Hiroko Kushige, Yutaka Saito, Yoichiro Shibuya, Shinsuke 
       Shibata, Wado Akamatsu, Hideyuki Okano, Yasuyuki S. Kida*, "Brief Exposure to 
       Neural Crest-like Precursors", FEBS Letters, vol. 591, pp. 590-602, (2017).

  21: Yuzo Takayama* and Yasuyuki S Kida*, "In Vitro Reconstruction of Neuronal Networks 
       e0148559, (2016).

  20: Yoichiro Shibuya, Yuzo Takayama, Hiroko Kushige, Sandra Jacinto, Mitsuru Sekido, Yasuyuki S Kida*, 
       Laboratory Animals, vol. 50, pp. 308-311, (2016).

  19: Akira Wagatsuma, Masataka Shiozauka, Yuzo Takayama, Takayuki Hoshino, Kunihiko Mabuchi, 
       Molecular and Cellular Biochemistry, vol. 412, pp. 50-72, (2016).

  18: Takuya Isomura, Kenta Shimba, Yuzo Takayama, Akimasa Takeuchi, Kiyoshi Kotani, Yasuhiko Jimbo, 
        Journal of Neural Engineering, vol. 12, art. no. 066023, (2015).

   17: Kenta Shimba, Koji Sakai, Yuzo Takayama, Kiyoshi Kotani, Yasuhiko Jimbo, "Recording axonal 
         conduction to evaluate the integration of pluripotent cell-derived neurons into a neuronal network",
        Biomedical Microdevices, accepted, (2015).

   16: Atsushi Saito, Yutaro Nakashima, Kenta Shimba, Yuzo Takayama, Kiyoshi Kotani, Yasuhiko Jimbo,   
        network integration", Biomaterials Science, vol. 3, pp. 1228-1235, (2015).

   15: Yuzo Takayama*, Akira Wagatsuma, Takayuki Hoshino, Kunihiko Mabuchi, 
        electrical stimulation of C2C12 myotubes", Biotechnology Progress, vol. 31, pp. 220-225 (2015).

   14: Atsushi Saito*, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo, 
        IEEE Transactions on Biomedical Engineering,Vol.61, No.2, pp. 463-472, (2014).

  
   13: Tatsuya Haga*, Osamu Fukayama, Yuzo Takayama, Takayuki Hoshino, Kunihiko Mabuchi,     
       overlapped neural spikes", Journal of Neuroscience Methods, vol.219, No.1, PP. 92-103, (2013).


   12: Leo Miyashita, Yuzo Takayama*, Tatsuya Haga, Takafumi Suzuki, Kunihiko Mabuchi, "Effects of     
        IEEJ Transactions of Electrical and Electronic Engineering, Vol.8, No.S1, pp. S108-S109, (2013).


   11: Akane Yasukawa, Yuzo Takayama*, Takafumi Suzuki and Kunihiko Mabuchi, "Construction of an 
        microfabrication techniques", IEEJ Transactions on Electrical and Electronic       
        Engineering, accepted(2012).


   10: Akimasa Takeuchi*, Kenta Shimba, Masahide Mori, Yuzo Takayama, Hiroyuki Moriguchi, 
        Kiyoshi Kotani, Jong-Kook Lee, Makoto Noshiro and Yasuhiko Jimbo, "Sympathetic neurons 
       Integrative Biology, Vol. 4, pp. 1532-1539, (2012).


   9: Yuzo Takayama*, Naoki Kotake, Tatsuya Haga, Takafumi Suzuki and Kunihiko Mabuchi, 
       combining with micropatterning techniques", Journal of Bioscience and Bioengineering, 
       Vol. 114, No. 1, pp. 92-95 (2012).


   8: Yuzo Takayama*, Hiroyuki Moriguchi, Kiyoshi Kotani, Takafumi Suzuki, Kunihiko Mabuchi, 
       BioSystems, Vol. 107, No. 1, pp. 1-8 (2012). 


   7: Yuzo Takayama*, Atsushi Saito, Hiroyuki Moriguchi, Kiyoshi Kotani, Takafumi Suzuki, 
       Kunihiko Mabuchi and Yasuhiko Jimbo, "Simultaneous induction of calcium transients in 
       Journal of Bioscience and Bioengineering, Vol. 112, No. 6, pp. 624-629 (2011).


   6: Yuzo Takayama, Atsushi Saito, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo, "Ensemble 
       Electronics and Communications in Japan, Vol. 94, No. 4, pp. 9-19 (2011).


   5: Akimasa Takeuchi*, Shingo Nakafutami, Hiromasa Tani, Masahide Mori, Yuzo Takayama
       Hiroyuki Moriguchi, Kiyoshi Kotani, Keiko Miwa, Jong-Kook Lee and Yasuhiko Jimbo, "Device for 
       Lab on a Chip,Vol. 11, pp. 2268-2275 (2011).


   4: Atsushi Saito, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo*, "Effects of 
       Carcinoma Cells", IEEJ Transactions on Electrical and Electronic Engineering, Vol. 6, No. 2, 
        pp. 157-162 (2011).


   3: Yuzo Takayama*, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo, "Spontaneous Calcium 
       IEEE Transactions on Biomedical Engineering, Vol. 56, No. 12, pp. 2949-2956 (2009).


   2: Yuzo Takayama*, Hiroyuki Moriguchi, Atsushi Saito, Kiyoshi Kotani, Yasuhiko Jimbo, "Ensemble 
        Electrical and Electronic Engineering, Vol. 4, No. 6, pp. 734-735 (2009).



   1: Suzurikawa J*, Takahashi H*, Kanzaki R, Nakao M, Takayama Y, Jimbo Y, "Light-addressable 
      stimulation of cultured neurons.", Appl. Phys. Lett., 90, 093901, 2007. [Selected for Virtual 
      Journal of Biological Physics Research, 13 (March 1, 2007)].

Books 

 



International Conferences 

  38: Yuzo Takayama, Naoki Kotake, Tatsuya Haga, Takafumi Suzuki, Kunihiko Mabuchi, "Formation of one- 
       way-propagated cultured neuronal networks using micro-fabrication and -fluidics techniques", The 8th 
       Forum of European Neuroscience, Poster presentation (16 July), Poster No. 71.21, Barcelona, Spain, 
       2012. 

  37: Atsushi Saito, Lui Yoshida, Kenta Shimba, Aki Saito, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi 
       Kotani, Yasuhiko Jimbo, "Development of magnetic nanoparticle-based in vitro 3D neuronal and glial 
       networks", The 8th Forum of European Neuroscience, Poster presentation (18 July), Poster No. 140.22, 
       Barcelona, Spain, 2012. 

  36: Kenta Shimba, Atsushi Saito, Akimasa Takeuchi, Yuzo Takayama, Kiyoshi Kotani, Yasuhiko Jimbo, 
       "Signal propagation on in vitro stem cell transplantation model", The 8th Forum of European 
       Neuroscience, Poster presentation (16 July), Poster No. 48.32, Barcelona, Spain, 2012.

  35: Akimasa Takeuchi, Kenta Shimba, Yuzo Takayama, Kiyoshi Kotani, Jong-Kook Lee, Makoto Noshiro, 
       Yasuhiko Jimbo, "Sympathetic neurons modulate beat rate of pluripotent cell-derived cardiomyocytes 
       in vitro", The 8th Forum of European Neuroscience, Poster presentation (15 July), Poster No. 40.10, 
       Barcelona, Spain, 2012.

  34: Yuzo Takayama, Naoki Kotake, Tatsuya Haga, Takafumi Suzuki, Kunihiko Mabuchi, "Formation of 
       one-way-propagated cultured neuronal networks using micro-fabrication and -fluidics techniques", MEA 
       meeting 2012 - 8th International Meeting on Substrate-Integrated Micro Electrode Arrays -, Poster 
       presentation (12 July), (Proceeding)pp.334-335, Reutlingen, Germany, 2012. 


  33: Kenta Shimba, Atsushi Saito, Akimasa Takeuchi, Yuzo Takayama, Kiyoshi Kotani, Yasuhiko Jimbo, 
       "Functional connection between differentiated and primary neurons", MEA meeting 2012 - 8th 
       International Meeting on Substrate-Integrated Micro Electrode Arrays -, Poster presentation (12 July), 
       (Proceeding)pp.338-339, Reutlingen, Germany, 2012. 


  32: Akimasa Takeuchi, Kenta Shimba, Yuzo Takayama, Kiyoshi Kotani, Jong-Kook Lee, Yasuhiko Jimbo, 
       "Effect of electrical stimulation on beat rate of pluripotent cell-derived cardiomyocytes innervated by 
       sympathetic neurons", MEA meeting 2012 - 8th International Meeting on Substrate-Integrated Micro 
       Electrode Arrays -, Poster presentation (12 July), (Proceeding)pp.155-156, Reutlingen, Germany, 2012. 


  31: Atsushi Saito, Lui Yoshida, Kenta Shimba, Aki Saito, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi 
       Kotani, Yasuhiko Jimbo, "Modulation of neuronal network activities using magnetic force-based 
       astrocytic network integration", MEA meeting 2012 - 8th International Meeting on Substrate-
       Integrated Micro Electrode Arrays -, Poster presentation (12 July), (Proceeding)pp.138-139, 
       Reutlingen, Germany, 2012. 


  30: Tatsuya Haga, Yuzo Takayama, Osamu Fukayama, Takafumi Suzuki, Kunihiko Mabuchi, "Analysis of 
       time-varying connection properties of cultured neuronal network under diverse conditions of electrical 
       stimuli", MEA meeting 2012 - 8th International Meeting on Substrate-Integrated Micro Electrode 
       Arrays -, Poster presentation (12 July), (Proceeding)pp.72-73, Reutlingen, Germany, 2012. 


  29: Miho Goto, Lui Yoshida, Atsushi Saito, Aki Saito, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi Kotani, 
       Yasuhiko Jimbo, "Formation of neuronal networks in vitro and analysis of neuronal avalanches", MEA 
       meeting 2012 - 8th International Meeting on Substrate-Integrated Micro Electrode Arrays -, Poster 
       presentation (12 July), (Proceeding)pp.45-46, Reutlingen, Germany, 2012. 


  28: Yuzo Takayama, Naoki Kotake, Tatsuya Haga, Takafumi Suzuki, Kunihiko Mabuchi, "Microfabrication 
      and Mirofluidics-based Patterning of Cultured Neuronal Network", 33rd Annual International   
      Conference of the IEEE Engineering in Medicine and Biology Society, oral presentation (ThC15.6, 
      1 Sep.), pp. 3613-3616, Boston, MA USA, 2011.


  27: Akimasa Takeuchi, Masahide Mori, Kana Kitagawa, Kenta Shimba, Yuzo Takayama, Hiroyuki Moriguchi, 
       Keiko Miwa, Kiyoshi Kotani, Jong-Kook Lee, Makoto Noshiro, Yasuhiko Jimbo, "Autonomic Nervous 
       System Drived Cardiomyocyte in Vitro", 33rd Annual International Conference of the IEEE 
       Engineering in Medicine and Biology Society, poster presentation (WeP24.7, 31 Aug.), pp. 1945-1948, 
       Boston, MA USA, 2011.  [2nd prize of IEEE EMBS Japan Young Investigators Competition for 
         EMBS2011 (JpCOMPEmbs11)] 


  26: Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi Kotani, Takafumi Suzuki, Kunihiko Mabuchi, Yasuhiko Jimbo, 
       "Evaluation and Control of Neuronal Differentiation Processes by using Micro-fabrication Techniques", 
       The 5th International Workshop on Approaches to Single-Cell Analysis, Poster No. 44, Tokyo, Japan, 
       2011. 


  25: Masahide Mori, Akimasa Takeuchi, Yuzo Takayama, Hiromasa Tani, Jong-Kook Lee, Kiyoshi Kotani, 
       Yasuhiko Jimbo, "Effects of Electrical Stimulation on Beating Rhythm of Cultured Ventricular Myocytes", 
       The 3rd Biomedical Engineering International Conference (BMEiCON 2010), Kyoto, Japan, 2010. 


  24: Takayama Y, Moriguchi H, Saito A, Kotani K, Jimbo Y, "Interaction of P19 cell-Derived Neuoronal 
       Networks and Mouse Cortical Networks Co-cultured on Micro-Electrode Array", The 7th Forum of 
       European Neuroscience, Poster No. 192.54, Amsterdam, The Netherlands, 2010. 


  23: Goto M, Moriguchi H, Saito A, Takayama Y, Kotani K, Jimbo Y, "The Measurement of Neuronal-Network 
       Activity using "Micropipette Drawing"", The 7th Forum of European Neuroscience, Poster No. 130.26, 
       Amsterdam, The Netherlands, 2010. 


  22: Saito A, Takayama Y, Moriguchi H, Kotani K, Jimbo Y, "Evaluation of Neuronal Differentiation of P19EC 
       Cells after Alterning Current Magnetic Fields Exposure", The 7th Forum of European Neuroscience, 
       Poster No. 11.56, Amsterdam, The Netherlands, 2010. 


  21: Yuzo Takayama, Hiroyuki Moriguchi, Atsushi Saito, Kiyoshi Kotani, Yasuhiko Jimbo, "Interactions of P19 
       cell-Derived Neuronal Networks and Mouse Cortical Networks Co-cultured on Microelectrode Array", 
       MEA meeting 2010 - 7th International Meeting on Substrate-Integrated Micro Electrode Arrays -, 
       (Proceeding)pp.84-85, Reutlingen, Germany, 2010. 


  20: Miho Goto, Hiroyuki Moriguchi, Yuzo Takayama, Aki Saito, Kiyoshi Kotani, Yasuhiko Jimbo, "Recordings 
       of Electrical Activity in Neuronal Network Patterned on MEA using Micropipette Drawing Method", 
       MEA meeting 2010 - 7th International Meeting on Substrate-Integrated Micro Electrode Arrays -, 
       (Proceeding)pp.309-310, Reutlingen, Germany, 2010. 


  19: Aki Saito, Hiroyuki Moriguchi, Miho Goto, Atsushi Saito, Yuzo Takayama, Kiyoshi Kotani, Yasuhiko 
       Jimbo, "Electrical and Optical Recording of Interactions between Small Neuronal Networks using Needle-
       Type Microelectrodes", MEA meeting 2010 - 7th International Meeting on Substrate-Integrated Micro 
       Electrode Arrays -, (Proceeding)pp.273-274, Reutlingen, Germany, 2010. 


  18: Atsushi Saito, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo, "The Effects of AC 
       Magnetic Fields on Neuronal Differentiation and Network Activities of P19EC Cells", MEA meeting 2010 - 
       7th International Meeting on Substrate-Integrated Micro Electrode Arrays -, (Proceeding)pp.88-89, 
       Reutlingen, Germany, 2010. 


  17: Yuzo Takayama, Hiroyuki Moriguchi,, Kiyoshi Kotani, Yasuhiko Jimbo, "Ensemble Stimulation of 
       Embryoid Bodies using Microfabricated ITO Substrates", The 31th Annual International 
       Conference of the IEEE Engineering in Medicine and Biology Society, pp. 5993-5996, Minneapolis, USA, 
       2009. [2nd prize of IEEE EMBS Japan Young Investigators Competition for EMBS2009 
        (JpCOMPEmbs09)] 


  16: Atsushi Saito, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo, "Developmental 
       International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 5942-5945, 
       Minneapolis, USA, 2009. 


  15: Atsushi Saito, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo, "Effects of ELFMF 
       Exposure on Differentiation and Spontaneous Activity of P19EC-derived Neuronal Cells", The 3rd 
       International Symposium on Biomedical Engineering, pp. 113 - 117, Bangkok, Thailand, 2008. 


  14: Shinya Hirota, Hiroshi Okamoto, Yuzo Takayama, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo, 
       "Study of in vitro Reconstruction of Visual Information Processing System", The 3rd International 
       Symposium on Biomedical Engineering, pp. 304 - 308, Bangkok, Thailand, 2008. 


  13: Yuzo Takayama, Atsushi Saito, Hiroyuki Moriguchi, Kiyoshi Kotani, Yasuhiko Jimbo, "Spontaneous 
       Electrical Activity in Neurons Derived from P19 Embryonal Carcinoma Cells", CNSI/CNBI Symposium on 
       NanoBiotechnology, Tokyo, Japan, 2008.


  12: Takayama Y., Saito A., Moriguchi H., Kotani K., Jimbo Y., "Neurons Derived from P19 Embryonal 
       Carcinoma Cells Establish Functional Neuronal Network Properties", The 6th Forum of European 
       Neuroscience, Poster No. 110.29, Geneva, Switzerland, 2008. 


  11: Moriguchi H., Tamai N., Takayama Y., , Kotani K., Jimbo Y., "Hierarchic Oscillatory Patterns Observed 
       in the Spontaneous and Evoked Activity of Cultured Small Recurrent Networks", The 6th Forum of 
       European Neuroscience, Poster No. 80.7, Geneva, Switzerland, 2008. 


  10: Yuzo Takayama, Hiroyuki Moriguchi, Atushi Saito, Kiyoshi Kotani, Yasuhiko Jimbo, "Neurons Derived 
       from P19 Embryonal Carcinoma Cells Establish Functional Neuronal Network Properties", MEA metting 
       2008 - 6th International Meeting on Substrate-Integrated Micro Electrode Arrays -, 
       (Proceeding)pp.103-104, Reutlingen, Germany, 2008. 


   9: Hiroyuki Moriguchi, Yuzo Takayama, Kiyoshi Kotani, Yasuhiko Jimbo, "Extracellular Recording from Mass-
       produced Small Neuronal Networks using Mobile Metal Microelectrodes", MEA metting 2008 - 6th 
       International Meeting on Substrate-Integrated Micro Electrode Arrays -, (Proceeding)pp.267-270, 
       Reutlingen, Germany, 2008. 


   8: Yuzo Takayama, Atushi Saito, Hiroyuki Moriguchi and Yasuhiko Jimbo, "Developmental Activity Changes 
      in P19EC-derived Neurons Cultured on Microelectrode Array", International Symposium on Biological and 
      Physiological Engineering, (Abstract)pp.163-164, Harbin, China, 2008. 


   7: Hiroyuki Moriguchi, Nobuhiro Tamai, Yuzo Takayama, Kiyoshi Kotani, Yasuhiko Jimob, "Site-selective 
      Stimulation and Recording of the Electrical Activity of Cultured Neuronal Networks using Mobile 
      Microelectrodes", International Symposium on Biological and Physiological Engineering, (Abstract)
      pp.159-162, Harbin, China, 2008. 


   6: Yuzo Takayama, Hiroyuki Moriguchi, Yasuhiko Jimbo, "Spontaneous Calcium Dynamics in the 
      Development of Cultured Cortical Networks", The 3rd International IEEE EMBS Conference on 
      Neural Engineering, (Proceeding)pp.77-80, Hawaii, USA, 2007.


   5: Hiroyuki Moriguchi, Nobuhiro Tamai, Yuzo Takayama, Yasuhiko Jimbo, "Site-Selective Electrical 
      Microelectrodes", The 3rd International IEEE EMBS Conference on Neural Engineering, 
      (Proceeding)pp.494-497, Hawaii, USA, 2007. 


   4: Suzurikawa J, Takahashi H, Takayama Y, Warisawa S, Mitsuishi M, Nakao M, Jimbo Y, "Light-
      passivation layer for stimulation of cultured neurons.", The 28th Annual International Conference 
      of the IEEE Engineering in Medicine and Biology Society, (Proceeding)pp.648-651, NewYork, USA, 2006. 


   3: Ozaki T., Morimoto K., Kurashima T., Takayama Y., Jimbo Y., "Cardiac Cells in vitro - Contraction and 
       Intracellular Ca Dynamics-", The 20th International CODATA Conference, (Abstract)pp.57, Beiging, 
       China, 2006. 


   2: Takayama Y. and Jimbo Y., "Developmental Changes of Intracellular Ca Dynamics in Cultured Cortical 
       Networks", The 5th Forum of European Neuroscience, (Abstract)pp.400, Vienna, Austria, 2006. 


   1: Yuzo Takayama, Yasuhiko Jimbo, "Modification of Evoked Responses Induced by Correlated Stimuli in 
       Cultured Cortical Networks" MEA metting 2006 - 5th International Meeting on Substrate-Integrated 
       Micro Electrode Arrays -, (Proceeding)pp.22-24, Reutlingen, Germany, 2006.

 

Last update:22 December, 2017
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