許元銘 Yuan-Ming Hsu | 研究成果 Publications

A. 期刊論文 Journal Articles

1. Wu TJ, Huang HH, Hsu YM, Lyu SR, Wang YJ. A novel method of encapsulating and cultivating adherent mammalian cells within collagen microcarriers. Biotechnology and Bioengineering. 2007 Oct 15;98(3):578-85. (SCI/EI; IF=3.946)

2. Chang SH, Hsu YM, Wang YJ, Tsao YP, Tung KY, Wang TY. Fabrication of pre-determined shape of bone segment with collagen-hydroxyapatite scaffold and autogenous platelet-rich plasma. Journal of Materials Science. Materials in Medicine. 2009 Jan;20(1):23-31. (SCI/EI; IF=2.316)

3. Hsu YM, Chang SH, Ko YC, Wang YJ. Prefabrication of vascularized bone segment with collagen microspheres and autogenous platelet-rich plasma. Bone, 2009 June;44:S272. (SCI; IF=4.023)

4. Hsu YM, Chen CN, Chiu JJ, Chang SH, Wang YJ. The effects of fiber size on MG63 cells cultured with collagen based matrices. Journal of Biomedical Material Research. Part B, Applied Biomaterials. 2009 Nov;91(2):737-45. (SCI; IF=2.147)

5. Chang CH, Liao TC, Hsu YM, Fang HW, Chen CC, Lin FH. A poly(propylene fumarate)--calcium phosphate based angiogenic injectable bone cement for femoral head osteonecrosis. Biomaterials. 2010 May;31(14):4048-55. (SCI/EI; IF=7.404)

6. Chang CH, Kuo TF, Lin FH, Wang JH, Hsu YM, et al. Tissue engineering-based cartilage repair with mesenchymal stem cells in a porcine model. Journal of Orthopaedic Research. 2011 Dec;29(12):1874-80. (SCI; IF=2.811)

7. Chen CC, Liao CH, Wang YH, Hsu YM, Huang SH, Chang CH, Fang HW. Cartilage fragments from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction. Journal of Orthopaedic Research. 2012 Mar;30(3):393-400. (SCI; IF=2.811)

8. Chang CH, Lee HC, Chen CC, Wu YH, Hsu YM, Chang YP, Yang TI, Fang HW. A novel rotating electrochemically anodizing process to fabricate titanium oxide surface nanostructures enhancing the bioactivity of osteoblastic cells. Journal of Biomedical Material Research. Part A. 2012 Jul;100(7):1687-95. (SCI; IF=2.625)

9. CH Chang,  YM Hsu, CN Hsiao, MH Chang,  TF Kuo*. Critical-sized Osteochondral Defects of Young Miniature Pigs as a Preclinical Model for Articular Cartilage Repair. Biomedical Engineering: Applications, Basis and Communications. 2014; 26, 1450003

10. CH Chang, CC Chen, CH Liao, FH Lin, YM Hsu, HW Fang*. Human Acellular Cartilage Matrix Powders as a Biological Scaffold for Cartilage Tissue Engineering with Synoviumderived Mesenchymal Stem Cells. Journal of Biomedical Materials Research: Part A. 2014 Jul;102(7):2248-57.

11. YM Hsu, CH Liao, YH Wei, HW Fang, HH Hou, CC Chen, CH Chang*. Daptomycinloaded Polymethylmethacrylate Bone Cement for Joint Arthroplasty Surgery. Artificial Organs. 2014 Jun;38(6):484-92.

12. CH Chang*, YM Hsu, FH Lin, S Sadhasivam, ST Loo, S Savithad. Anti-inflammatory effects of hydrophilic and lipophilic statins with hyaluronic acid against LPS-induced inflammation in porcine articular chondrocytes. Journal of Orthopaedic Research. 2014 Apr;32(4):557-65.

13. K Wu, YC Chen, YM Hsu, CH Chang*. Enhancing Drug Release From Antibiotic-loaded Bone Cement Using Porogens. Journal of The American Academy Orthopaedic Surgeons. 2016 Mar;24(3):188-95.

14. YC Chen, YM Hsu, KP Tan, HW Fang, CH Chang*. Intraarticular injection for rabbit knee osteoarthritis: effectiveness among hyaluronic acid, platelet-rich plasma, and mesenchymal stem cells. Journal of the Taiwan Institute of Chemical Engineers. 2018; 91:138–145.

15. Chen YC, Liao HJ, Hsu YM, Shen YS, Chang CH. Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model. Polymers (Basel). 2022 Apr 5;14(7):1474.

16. EH C. Brun, ZY Hong, YM Hsu,, CT Wang, DJ Chung, SK Ng, YH Lee, TT Wei. Stability and Activity of Interferon Beta to Treat Idiopathic Pulmonary Fibrosis with Different Nebulizer Technologies. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2023 Apr;36(2):55-64.

B. 雜誌 Magazine Articles

1. EH C. Brun, YM Hsu. Delivering Suspensions With Mesh Technology. ONdrugDelivery, 2021 Nov;127: 8–41.

2. EH C. Brun, YM Hsu. A Roadmap for Drug-nebulizer Combination Product Development. ONdrugDelivery, 2022 Nov; 140: 54-58.

3. EH C. Brun, YM Hsu. Advancements in Monitoring Adherence - A Smart Mesh Nebulizer. ONdrugDelivery, 2022 Dec; 141: 22-26.

4. EH C. Brun, YM Hsu. The Value of Customisable Mesh Nebuliser Platforms in Combination Product Development. ONdrugDelivery, 2023 Nov; 154: 13–17.

5. EH C. Brun, YM Hsu. Customisable Nebuliser Platform to Monitor Adherence. ONdrugDelivery, 2023 Dec; 155: 16–20.

C. 研討會論文 Conference Papers

  國際研討會 International Conferences

1. Hsu YM, Chang SH, Wang YJ. (Oral) In Vivo Engineering Bone Segment Using Collagen Microspheres Loaded With Bone Marrow Mesenchymal Stem Cells. 2007, International Symposium, Bioengineering and Regenerative Medicine, Mulhouse, France.

2. Hsu YM, Chang SH, Ko YC, Wang YJ. (Poster) Prefabrication of vascularized bone segment with collagen microspheres and autogenous platelet-rich plasma. 2009, ECTS 36th European Symposium on Calcified Tissues, Vienna, Austria.

3. Chang CH, Liao TC, Hsu YM, Lin FH. Development of A Novel Angiogenic Composite as Injectable Bone Cement for Osteonecrosis of Femoral Head. 2010, 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA.

4. Hsu YM, Liao CH, Fang HW, Chang CH. Cartilage tissue engineering with acellular cartilage matrix and synovial stem cells. 2010, 9th World Congress of the International Cartilage Repair Society, Barcelona, Spain.

5. YM Hsu, HH Hou, FH Lin, CH Chang. In situ gelling cell-laden hydrogel as injectable cartilage tissue engineered implant. SICOT 2011 XXV Triennial World Congress, Prague, Czeck.

6. CH Chang, PY Chen, HH Hou, JW Huang, KY Chang, YM Hsu. Development of a hyaluronic acid incorporated hydroxyapatite/calcium sulfate bone cement for promoting bone reconstruction. SICOT 2011 XXV Triennial World Congress, Prague, Czeck.

7. CH Chang, JS Hu, CC Chen, HW Fang, YM Hsu. The Effects of Articular Cartilage Fragments and Synovial Membranes on Chondrogenesis of Bone-Marrow-Derived Mesenchymal Stem Cells. OARSI 2012 World congress, Barcelona, Spain.

8. YM Hsu, SM Wu, YM Sun, CH Chang. Development of electrospun composite scaffolds of poly(3-hydroxybutyrate)/bioceramics for osteogenic cell engineering. 2012, 12th Asian BioCeramics (ABC2012) Symposium, NCKU, Tainan, Taiwan.

9. YM Hsu, HW Fang, CH Chang. Development of a Collagen-Ceramic Bone Substitute with Sustained-release Calcitonin for Improving Bone Defect Repair. 2013, Annual Meeting of the Orthopaedic Research Society, San Antonio, USA.

10. CH Chang, YM Hsu, CH Liao. Feasibility of Daptomycin-loaded Polymethylmethacrylate Bone Cement for Infection Prophylaxis in Joint Arthroplasty Surgery. 2013, Annual Meeting of the Orthopaedic Research Society, San Antonio, USA.

11. CH Chang, YM Hsu, FH Lin. Anti-inflammatory effects of hydrophilic and lipophilic statins with hyaluronic acid in articular chondrocytes. 2013, 11th World Congress of the International Cartilage Repair Society  Izmir, Turkey.

12. YM Hsu, CH Chang. hTERT-gene transfected mesenchymal stem cells combined with in-situ gelation hydrogel for cartilage regeneration in a porcine model. 2013, 8th triennal Meeting of the Combined Orthopaedic Societies, Venice, Italy.

13. EH C. Brun, CT Wang, JS Chen, YM Hsu, YY Chen, HA Tsai and KT Chen. In-Vitro Study of Inhaled Iloprost Delivery Using a Modified Deepro Mesh Nebulizer with Breath-Actuated Function. 2020, Drug Delivery to the Lungs, virtual conference due to COVID-19.

14. EH C. Brun, CT Wang, IC Chen, M Liu, JS Chen, YM Hsu, YY Chen, HA Tsai and KT Chen. Nebulization of Mucolytic Agent – MESNA – Using Different Nebulizer Technologies with Adult and Child Breathing Patterns. 2021, Respiratory Drug Delivery, virtual conference.

15. EH. C. Brun, HA Tsai, CT Wang, YM Hsu, KT Chen. Aerodynamic Particle Size Distribution and Delivered Dose Efficiency of a Continuous-output MeshN ebuliser and a Novel Breath-actuated Device using Terbutaline Sulphate. 2021, Drug Delivery to the Lungs, virtual conference.

16. EH C. Brun, CT Wang, YT Chen, YM Hsu, HA Tsai, JS Chen. Aerosol Delivery Performance of Interferon Beta-1b with a Continuous Output Mode Mesh Nebulizer and a Breath-Actuated Mesh Nebulizer. 2022, Respiratory Drug Delivery, Florida, USA.

17. HA Tsai, YT Chen, EH C. Brun, CT Wang, YM Hsu, JS Chen. Assessing Delivered Dose of a Breath-Actuated Mesh Nebulizer: Breathing Simulator vs. NGI with Mixing Inlet Using Ipratropium Bromide. 2022, Respiratory Drug Delivery, Florida, USA.

18. EH C. Brun, CT Wang, YT Chen, JS Chen, YM Hsu. Assessment of Fugitive Aerosol Emission During Actuation of a Breath-actuated Mesh Nebuliser. 2022, Drug Delivery to the Lungs, Edinburgh, UK.

19. EH C. Brun, CT Wang, YT Chen, CT Liu, YH Lin, YM Hsu. Assessment of Aerosol Characterisation and Delivery Performance of a Solution Using Different Configurations of a Breath-Actuated Mesh Nebuliser. 2023, Drug Delivery to the Lungs, Edinburgh, UK.

  國內研討會 Domestic Conferneces

1. 許元銘 楊炯琳 王盈錦. (Poster) 可注射式含氫氧基磷灰石之膠原蛋白微粒的新製程之研發（Development of a Novel Process of Injectable Collagen Microspheres Containing Hydroxyapatite. 2003, 全國醫學工程年會, 台北, 台灣.

2. 張世幸 許元銘 董光義 蕭弘道 王盈錦. 以膠原蛋白微粒及富含血小板血漿進行血管化骨移植物之研究 (Fabrication of Pre-Determined Shape Vascularized Bone Graft with Hydroxyapatite- Collagen Gel Beads Scaffold and Autogenous Platelet-Rich Plasma). 2009, 中華民國整形外科醫學會-第14屆第2次會員大會暨學術研討會, 高雄, 台灣.

3. YM Hsu, HH Hou, FH Lin, HW Fang, CC Chen, CH Chang. (Oral) Characterization of a novel cellulose/chitosan based hydrogel for cartilage tissue engineering. 2010, International Symposium of Materials on Regenerative Medicine, NHRI, Miaoli, Taiwan.

4. YM Hsu, HH Hou, HW Fang, CC Chen, CH Chang. (Poster) Development of daptomycin premixed PMMA bone cement for infection prevention. 2010, International Symposium of Materials on Regenerative Medicine, NHRI, Miaoli, Taiwan.

5. YM Hsu, HH Hou, HW Fang, CC Chen, CH Chang. (Poster) In vivo assessment of a hydroxyapatite/calcium sulfate bone cement in a rabbit model. 2010, International Symposium of Materials on Regenerative Medicine, NHRI, Miaoli, Taiwan.

6. YM Hsu, HC Lee, CC Chen, HW Fang, CH Chang. (Oral) Enhancement of osseointegration on titanium surface by anodizing process. 2010, 16th Triennial Congress of the Asia Pacific Orthopaedic Association and 59th Annual Meeting of Taiwan Orthopaedic Association, NTU, Taipei, Taiwan.

7. YM Hsu, HH Hou, HW Fang, CC Chen, CH Chang. (Poster) Evaluation of a hydroxyapatite/Calcium sulfate biodegradable bone cement. 2010, 16th Triennial Congress of the Asia Pacific Orthopaedic Association and 59th Annual Meeting of Taiwan Orthopaedic Association, NTU, Taipei, Taiwan.

8. YM Hsu, HH Hou, SH Huang, CH Liao, HW Fang, CC Chen, CH Chang. (Poster) In vitro assessments of the daptomycin-loaded PMMA bone cement. 2010, 16th Triennial Congress of the Asia Pacific Orthopaedic Association and 59th Annual Meeting of Taiwan Orthopaedic Association, NTU, Taipei, Taiwan.

9. YM Hsu, HH Hou, HW Fang, CC Chen, FH Lin, CH Chang. (Poster) Development of a dialdehyde methyl cellulose/succinyl chitosan injectable hydrogel for cartilage repair. 2010, 16th Triennial Congress of the Asia Pacific Orthopaedic Association and 59th Annual Meeting of Taiwan Orthopaedic Association, NTU, Taipei, Taiwan.

10. CH Liao, CC Chen, HW Fang, YM Hsu, CH Chang. (Poster) Applying synovial mesenchymal stem cells and acellular cartilage matrix for cartilage tissue engineering. 2010, 16th Triennial Congress of the Asia Pacific Orthopaedic Association and 59th Annual Meeting of Taiwan Orthopaedic Association, NTU, Taipei, Taiwan.

11. 蔡志煜，朱一民，魏毓宏，張至宏，許元銘，生物可降解材料PHBV微球之製備與藥物釋放之研究，2012, 17th Conference on Biochemical Engineering，Kaohsiung, Taiwan.

12. 蘇玥文，魏毓宏，黃實宏，張至宏，許元銘，不同光源對Serratia marcescens SM△R 菌體生長及合成Prodigiosin之影響，2012, 17th Conference on Biochemical Engineering，Kaohsiung, Taiwan.

13. YM Hsu, HH Hou, PY Chen, KY Chang, CH Chang. (Poster) Osteoinductive capacity of hyaluronic acid incorporated ceramic bone cement. 2012, The 2nd International Symposium of Materials on Regenerative Medicine, TMU, Taipei, Taiwan.

14. YM Hsu, CH Chang, LH Hsiao, KP Tan. (Poster) Evaluation of The Abilities of hTERT Transfected Porcine Bone Marrow Mesenchymal Stem Cells for Chondrogenic Differentiation. 2012, Annual Symposium of Biomedical Engineering and Technology, CYCU, Taoyuan, Taiwan.

15. SM Wu, YM Hsu, YM Sun, CH Chang. (Poster) Evaluation of graft and electrospun scaffolds based on poly(3-hydroxybutyrate)/hydroxyapatite composite as substrates for orthopedic application. 2012, Annual Symposium of Biomedical Engineering and Technology, CYCU, Taoyuan, Taiwan.

16. 許元銘，張至宏，蕭莉馨，陳瑾霈，以原位成膠之水膠包覆經人類端粒酶反轉錄酵素基因轉殖之幹細胞作為軟骨再生之療法 (Porcine Mesenchymal Stem Cells of hTERT-gene Transfection combined with in-situ gelation hydrogel for Cartilage Regeneration). 2013, 台灣再生醫學學會年會, 台北, 台灣.

D. 技術報告與演講 Research Reports & Talks

1. 許元銘 張至宏. (Oral) 醫療器材臨床試驗的設計原則:以骨科材料為例. 2009, 遠東集團產學合作聯盟-生技醫療交流平台研討會, 亞東技術學院, 新北市, 台灣.

2. 許元銘 張至宏. (Oral) 骨水泥的開發與臨床前測試. 2010, 遠東集團與元智大學產學合作聯盟-生物科技工作平台會議, 遠東新世紀, 桃園, 台灣.

3. 許元銘 張至宏. (Oral) 以透明質酸複合氫氧基磷灰石/硫酸鈣骨水泥以促進硬骨重建的產品開發. 2011, 遠東集團生技平台交流研討會, 亞東紀念醫院, 新北市, 台灣.

4. 許元銘 張至宏. (Oral) 用於促進軟骨缺損修復的水膠開發--體外與體內實驗. 2012, 元智大學與遠東集團交流平台研討會, 元智大學, 桃園, 台灣.

   1. 許元銘 張至宏. (Oral) 富血小板血漿在骨科的應用.  2012, 遠東集團生技醫藥交流平台研討會, 亞東技術學院, 新北市, 台灣.

5. 許元銘. (Oral) 脂肪間葉幹細胞產品的初期產業化歷程. 2015『複合醫材與細胞治療產品研發聯盟』細胞治療技術應用研討會, 南港展覽館, 台北, 台灣.

6. 許元銘. (Oral) 醫療器材臨床詴驗設計-跨國多中心執行經驗. 2018『體外診斷醫療器材臨床詴驗設計與實務』衛生福利部食品藥物管理署, 中國醫藥大學附設醫院, 台中, 台灣

7. 許元銘. (Oral) 多國多中心之臨床試驗監測與稽核之執行.  2018『醫療器材臨床試驗GCP查核教育訓練』財團法人醫藥品查驗中心, 林口長庚紀念醫院, 新北市, 台灣

8. 許元銘. (Oral) 醫療器材開發與跨國臨床實驗經驗分享. 2018 台大PMBM 生物科技管理碩士在職學位學程『生技醫藥產業實務概論』, 國立台灣大學竹北分部, 新竹, 台灣

9. 許元銘. (Oral) 醫療器材臨床試驗的設計與執行. 2019 中國醫藥大學生物科技學系必修科目『生技產業之現況與發展』, 中國醫藥大學, 台中, 台灣

E. 其他著作 Other publications

1. 骨填補產品知多少，遠東人月刊，2013年/03月號 (備份連結)

   1. 脊椎骨折不可輕忽──認識椎體整型術，遠東人月刊，2013年/08月號 (備份連結)

2. 骨缺損治療知多少，遠東人月刊，2014年/05月號 (備份連結)

3. 生醫材料：導言，科技大觀園＞新知報＞專題報導，2014年10月上線

F. 專利Patents

1. 中華民國專利證書 發明第I400101號 ，專利名稱「治療股骨頭壞死之刺激血管新生性注射式可降解骨水泥」。

2. 中華民國專利證書 發明第I414326號，專利名稱「具有骨誘導能力之骨水泥」。

3. 中華民國專利證書 發明第I414327號，專利名稱「複合性骨水泥」 。

4. 中華民國專利證書 發明第I436795號，專利名稱「一種注射式骨填補物」。

5. 中華民國專利證書 發明第I750067號 (CN: 115120819B)，專利名稱「霧化裝置以及噴嘴模組」。

6. 中華民國專利證書 設計整體第D212868號 (US: D972714; CN: 306482448S)，專利名稱「霧化器」。

7. 中華民國專利證書 發明第I747773號，專利名稱「給藥容器以及霧化裝置」。

8. 中華民國專利證書 新型第M614315號，專利名稱「霧化器」。

9. 中華民國專利證書 發明第I761074號 (CN: 114904096B)，專利名稱「霧化器」。

G. 授課 Lectures

1. 元智大學 生物科技與工程研究所 兼任助理教授

2. 台北科技大學 生醫材料、骨科材料開發

3. 亞東技術學院 再生醫學、細胞治療

4. 經國管理暨健康學院  肌肉與骨骼系統的物理治療：徒手治療技術

H. 榮譽及獲獎 Honors and Awards

1. 2011年 第八屆 國家新創獎 (8th National Innovation Award) 學術研究組 「治療股骨頭壞死之刺激血管新生性注射式可降解骨水泥」

I. 進修Advanced training for professionals

1.  Design and Interpretation of Clinical Trials (2015) - a 6 week online non-credit course authorized by Johns Hopkins University and offered through Coursera (Link  to show the details of course, grade and Verified Certificate)(Link to the Certificate only)