Funding

[ACTIVE]

• ACED (University of Cambridge/UCL/OHSU): "Mapping intestinal metaplasia progression across the upper gastrointestinal tract through a common precancer lens" 

• CEDAR project: "Making multiplex tissue imaging broadly accessible in the clinic: detection and stratification of early prostate cancer lesions"

• Jayne Koskinas Ted Giovanis Foundation for Health and Policy: "Development of a prototype multiscale model designed to predict therapeutic responses of tumor"  (Drs. Heiser/Chang/Macklin (IU))
  
  

• NIH/NCI R01 CA253860 (PI: Drs. Chang & Wong)

  • Integrative single cell analyses of inflammation-derived circulating hybrid cells to identify aggressive disease
    
    

• NIH/NCI R01 CA260196 (PI: Drs. Wong & Gibbs)

  • Mechanistic understanding of the lifecycle of a circulating hybrid cell
    
    

• Kuni Foundation (PI: Heiser)

  • A Preclinical Approach to Targeting Cell State in Aggressive Metastatic Breast Cancer
    
    

• Knight Cancer Institute (PI: Wang)

  • OregonFluor Technology to Enhance Multiplex Quantitative Immunofluorescence in Human Cancer
    
    

• NIH/NCI U2C CA233280 (PI: Dr. Gray)                                                                                                          

  • Human Tumor Atlas Research Center

  • OMS Atlas of Metastatic Breast & Prostate Cancers

  • NIH/NCI TNP - SARDANA   (PI: Dr. Gray)                                                                                                          

  • NIH/NCI TNP - TMA (PI: Dr. Gray)             
                                                                                                

• OHSU SMMART

[DONE]

• Kuni Foundation Imagination Grants (PI: Dr. Chang)

  • Supercharging digital pathology with artificial intelligence

• CRUK/OHSU JOINT FUNDING AWARD (PIs: Dr. Zhuang [CRUK] and Chang [OHSU])

  • Deciphering the immune complexity in oesophageal adenocarcinoma and pre-cancerous lesions with multiplex immunostaining and Sparse Subspace Clustering (SSC) approach

• NIH/NCI U01CA224012-01A1 (PI: Dr. Sears)

  • Comparative analysis between patient-derived models of pancreatic ductal adenocarcinoma and matched patient specimens

• NIH/NIGMS R01 GM122854-01A1 (PI: Dr. Beatty)                                                                                                

  • A New Technology for Tracking Proteins by Light and Electron Microscopy

  • The goal is developing new chemical probes (i.e., coiled-coil protein tags) that are compatible with both fluorescence and electron microscopy which enable to probe cellular proteins at the nanoscale and to reveal new insights into cellular iron homeostasis.

• NIH/NCI U54 CA209988 (PI: Dr. Gray)                                                                                                          

  • Measuring, Modeling and Controlling Heterogeneity

  • The goal is to develop a systems level understanding of how intrinsic and extrinsic factors work together to enable TNBCs to escape therapeutic control and devise robust control strategies.

  • CSBC Admin Supplement (PI: Dr. Gray)

• Knight Pilot Award (FY 20 Fall, PIs: Dr. Vu, Lind, Chang)

  • Imaged-based Machine Learning For Comprehensive Identification of Drug Combination Effectiveness on Immune Cell-Mediated Tumor Cell Kill

• NCI SBIR 1R44CA224994-01 (PI: Dr. Nederlof)                                                                                                     

  • Ultra-High Content Analysis (UHCA) of Single Cells in Tissue: 60+ channel immunofluorescence labeling kits and companion imaging software for everyone

  • The goal is to create a modular suite of products that will make highly multiplexed imaging of individual cells in intact tissue available to a wide range of laboratories through validated labeling kits and companion imaging software that promotes discovery through interactive image and data visualization.

  • Phase II SBIR subaward "Ultra-High Content Analysis (UHCA) of Single Cells in Tissues: 60+ channel immunofluorescence labeling kits and companion imaging.” (subPI: Gray)

• Biomedical Innovation Program (PI: Dr.  Chang)

  • "ParadigmSHIFT: Speedy Histopathological-to-ImmunoFluorescent Translation of medical images by deep learning" by Erik Ames Burlingame, Geoffrey Frederick Schau, Christopher Corless and Young Hwan Chang

• Brenden-Colson Center for Pancreatic Care’s pilot (PI: Dr. Chang)

  •  TIME* matters in pancreatic cancer (*tumor immune microenvironment)

• CRUK-OHSU Spark Award (PI: Dr. Zhuang / Chang)

  •  Deciphering the immune microenvironment in oesophageal adenocarcinoma and pre-cancerous lesions to a single cell resolution

• Center for Early Detection Research, Knight Cancer Institute (PIs: Drs. Wong / Vu)                                       

  • Harnessing Circulating Hybrid Cell Bio & Ultrasensitive Imaging Technology for Early Detection of PDAC

• Center for Early Detection Research, Knight Cancer Institute (PI: Dr. Leachman)             

  • Risk Stratification of Early Melanomas by Deep Histopathological Analysis