Quantitative BioImaging Lab.

Young Hwan Chang, Ph.D; Associate Professor in the Department of Biomedical Engineering (BME); the Computational Biology Program in the School of Medicine; OHSU Center for Spatial Systems Biomedicine, Co-Leader, Knight Cancer Institute Quantitative Oncology Program, Affiliate of the Center for Biomedical Data Science (CBDS), Oregon Health and Science University (OHSU)

Biography: Dr. Young Hwan Chang received his Ph.D in Mechanical Engineering from University of California, Berkeley under the supervision of Prof. Claire J. Tomlin (EECS). Then, he worked as a postdoctoral researcher at Hybrid Systems Laboratory in the Department of Electrical Engineering and Computer Sciences, UC Berkeley. Previously, he also worked at Cognitive Robotics Research Center, Korea Institute of Science and Technology (KIST) and Hyundai-Kia R&D Center. 

Research Interests: Quantitative imaging analysis, Multiplex tissue imaging, Computational modeling of biological systems, Multimodal integration, ML/DL, Control theory

Lab Philosophy: Passionate & Self-motivated Team Player

Google Scholar      ORCID

What's up in QBI Lab? 

• June 2025: Welcome Suin Jung (B-BRITE Summer Intern, Brown University)!

• May 2025: Congrats Mark! "UniFORM: Towards Universal Immunofluorescence Normalization for Multiplex Tissue Imaging" has been accepted in Cell Reports Methods

• May 2025: Congrats Zac! Abstract submission ("Automated Rule Synthesis from Literature for Agent-Based Modeling of the Tumor Microenvironment ") has been accepted AACR Special Conference on AI and Machine Learning

• May 2025: Congrats Zac and Sandhya (top 9% of 3,667 submissions) MICCAI 2025

• April 2025: YH was invited to talk ("Advancing multiplex tissue imaging: 3D reconstruction and Panel reduction") at the ASIP Pathobiology 2025

• April 2025: New bioRxiv papers from the lab:

  • Language of Stains: Tokenization Enhances Multiplex Immunofluorescence and Histology Image Synthesis (link)

  • Automated Quality Control of Time-Course Imaging from 3D in vitro cultures (link)

• Mar 2025: Zac attends Nvidia GTC and presents poster titled "Learning a Language of Stains: Tokenization Facilitates Interpretable Multiplex Immunofluorescence and Histology Image Synthesis"

• Feb 2025: Eric presents poster titled "Exploring Tumor Microenvironment States by Simulating Different Conditions in an Agent-Based Model" at the Gordon Research Conference (Bridging Theory and Technologies in Physical Oncology)

• Jan 2025: YH attends the Advanced Workshop on Research Skills in Oncology (Center for Palliative Care, HMS)

• Jan 2025: Our collaborative application to the KCI Pilot Award was selected for funding (Drs. Chi, Chang, Heiser, Creason), "Spatial Multi-Omics and Multiplex Tissue Imaging Integration for Mapping Metabolic Niches in Triple-Negative Breast Cancer (TNBC)."

• Happy New Year!