Oct.16 2017 - June 11 2021
Getz Lab (Postdoctoral Fellow) (Dr. Gad Getz, Broad Institute of MIT and Harvard)
Studying circulating tumor cell (CTC) biology using a genomics approach
Collaboration with the Daniel Haber lab at MGH Cancer Center
Identified melanoma circulating tumor cell (CTC)-specific transcriptional states associated with metastasis and treatment resistance using bulk RNA-seq and ChIP-seq of CTC-derived cell lines and scRNA-seq of primary CTCs.
Tumor expression subtyping and integration of multi-omics data and functional data from human tissues and cancer models for identification of biomarkers and cancer vulnerabilities
Performed genomic, proteomic, and functional characterization of novel lung cancer expression subtypes by integrative analysis of TCGA, CPTAC, DepMap, and SMC-LUAD data using the BayesNMF approach.
Identified novel subtype-specific driver mutations and cancer vulnerabilities.
Mar.17 2014 - Sep. 22 2017
Futreal Lab (Graduate Research Assistant) (Dr. Andrew Futreal, Dept. of Genomic Medicine, MD Anderson Cancer Center)
Performed integrative analysis of multi-omics data from longitudinal metastatic melanoma biopsies treated with sequential CTLA-4 and PD-1 blockade to identify resistance mechanisms and to discover genomic biomarkers of response
Collaboration with the Jennifer Wargo lab at MD Anderson Cancer Center
Identified that adaptive immune signatures in early on-treatment tumor biopsies are predictive of response to immune checkpoint blockade.
Identified that high copy number loss in tumors (including recurrent copy number loss in PTEN) was associated with resistance to immune checkpoint blockade.
Jan.6 2014 - Mar.7 2014
Barton Lab (Rotation Student) (Dr. Michelle Barton, Dept. of Genetics, Dept. of Biochemistry and Molecular Biology, MD Anderson Cancer Center)
Estrogen-dependent binding of TRIM24 to chromatin in MCF7 cells
Analyzed ChIP-seq data to find target genes and transcriptional co-regulators of TRIM24 in MCF7 cells
Sept.9 2013 - Nov.15 2013
Navin Lab (Rotation Student) (Dr. Nicholas Navin, Dept. of Genetics, Dept. of Bioinformatics and Computational Biology, MD Anderson Cancer Center)
Intratumor heterogeneity in Triple-Negative Breast Cancer (TNBC)
Analyzed single-cell exome sequencing data to study intratumor heterogeneity in TNBC
July 2012 - July 2013
Genomic Medicine Institute (Assistant Research Scientist) (Dr. Jeong-Sun Seo, Medical Research Center, Seoul National University)
Northeast Asian Exome Sequencing Project
Analyzed whole-exome sequencing data from 126 Northeast Asian individuals including Korean, Chinese, Japanese, and Mongolian ethnicities
Developed whole exome sequencing data analysis pipeline
Performed population genetic analyses
Intra-population analysis : Molecular diversity, Tajima’s neutrality test (DaDi)
Inter-population analysis : Fst-Pairwise genetic distances, Detection of loci under selection from F-statistics (BayeScan)
Population structure and admixture analysis : PCA, DAPC, Neighbor-Joining Tree (adegenet R package)
Demographic History Modeling : Model-based demographic history inference using derived allele frequency (DaDi)
Developed the web database for SNP, Indel, CNV, and Genotype information from 126 whole exome sequencing data
July 2010 – July 2012
Bioneer Corporation (Associate Research Engineer, Bioinformatics Team)
Developed the software for gene synthesis service (in collaboration with the synthetic biology team)
Developed oligonucleotide design software module (design oligonucleotide sets for gene assembly by LCR and PCR)
Developed synthetic gene assembly with error correction software module
Developed the software for qPCR gene expression profiling service
Performed medical device clinical trial design and management
Performed statistical design and validation of molecular diagnostic kits
Developed the software for qPCR quantification using statistical signal processing algorithm