Research

We study biophysical and materials based research problems using theoretical and computational approaches rooted in molecular thermodynamics and statistical mechanics. Specifically, we study the functional behavior of complex macromolecules (proteins, nucleic-acids, polymers, lipids, colloids) and their applications in therapeutic design, molecular engineering, and materials discovery. We often collaborate with research groups having complementary experimental expertise in biochemical, biophysical, structural, synthesis, and characterization methods. Some research problems of current interest are listed below.

• Structure and function of protein receptors (e.g. Receptor tyrosine kinases; G-protein coupled receptors) 

• Structure and function of large enzymes in photoreceptor signaling 

• Dynamics and interactions in nucleic acids, especially viral RNA molecules

• Discovery of novel small molecules and peptides for various biomolecular targets 

• Characterization of peptide/membrane interactions

• Nanoscale design of porous biomaterials based on self-assembly of colloids

• Design of DNA-based nanomaterials with chiroptical properties

• Design of biomimetic and bioinspired membranes involving artificial channels 

• Design of conductive and sensing materials based on Metal Organic Frameworks (MOFs)

• Development of new methods for characterizing biomolecules and novel materials