Publications

Journal Papers 

(*) shows graduate students supervised. (⁺) denotes co-authors from the industry. 

1. Wang*, B., Xie, W., Martagan, T. G., Akcay, A., van Ravenstein⁺, B. (2024) Biomanufacturing Harvest Optimization with Small Data. Forthcoming at Production and Operations Management.

2. Martagan, T., Baaijens⁺, M., Dirckx*, C., Holman⁺, J., Meyers⁺, R., Repping⁺, O., van Ravenstein⁺, B. (2024) MSD: Continuous Pharmaceutical Manufacturing Data for the 2024 Manufacturing and Service Operations Data-Driven Research Challenge. Manufacturing & Service Operations Management. https://doi.org/10.1287/msom.2024.0860 

3. Singh*, N., Akcay, A., Dang, V., Martagan, T., Adan, I. (2024) Dispatching AGVs with Battery Constraints using Deep Reinforcement Learning. Computers and Industrial Engineering 187, 109678. https://doi.org/10.1016/j.cie.2023.109678 

4. Limon, Y., Martagan, T., Krishnamurthy, A. (2024) Contracts for Biopharmaceutical Manufacturing Based on Production Cost and Capabilities. International Journal of Production Research, 62(7), 2640-2662. http://dx.doi.org/10.1080/00207543.2023.2222011. 

5. Martagan, T., Adan I., Baaijens⁺, M., Dirckx*, C., Repping⁺, O., Ravenstein⁺, B., Yegneswaran⁺, P. (2023) Merck Animal Health uses Operations Research Methods to Transform Biomanufacturing Productivity for Lifesaving Medicines.  INFORMS Journal on Applied Analytics, 53(1), 85-95. https://doi.org/10.1287/inte.2022.1147 

   • Finalist of 2022 INFORMS Franz Edelman Award. 

6.  Koca,* Y., Martagan, T., Adan, I., Maillart, L., van Ravenstein⁺, B. (2023) Increasing Biomanufacturing Yield with Bleed-Feed: Optimal Policies and Insights. Manufacturing & Service Operations Management, 25(1), 108-125. https://doi.org/10.1287/msom.2022.1163 

   • Second prize winner, 2021 INFORMS Innovative Applications in Analytics Award.

7.  Koca,* Y., Martagan, T., Adan, I. (2023)  Optimising the fermentation throughput in biomanufacturing with bleed–feed.  International Journal of Production Research,  (61)2, 427-446.  https://doi.org/10.1080/00207543.2021.2009140

8. Olsder,* W., Martagan, T., Tang, C. (2023) Improving Access to Rare Disease Treatments: Subsidies, Pricing and Payment Schemes. Management Science, 69(9), 5256-5274  https://doi.org/10.1287/mnsc.2022.4634 

9. Dang, V., Herps,* K., Martagan, T.,  Adan, I., Heinrich,* J. (2023). Unsupervised Parallel Machines Scheduling with Tool Switches. Computers and Operations Research, 160, 106361. https://doi.org/10.1016/j.cor.2023.106361

10. Olsder,* W., Martagan, T., Tang, C. (2023) Converting a Drug From Off-Label to On-Label Use: Government Subsidies and Patient Welfare.  Decision Sciences, 54(6), 579-595. https://doi.org/10.1111/deci.12574 

    • Top downloaded article during its first 12 months of publication in Decision Sciences.

11. Herps,* K., Dang, V., Martagan, T., Adan, I. (2022) A simulation-based approach to design an automated high-mix low-volume manufacturing system.  Journal of Manufacturing Systems, 64, 1-18. https://doi.org/10.1016/j.jmsy.2022.05.013

12. Singh,* N., Dang, V., Akcay, A., Adan, I., Martagan, T. (2022) A Matheuristic for AGV Scheduling with Battery Constraints.  European Journal of Operational Research, 298(3)  855-873. https://doi.org/10.1016/j.ejor.2021.08.008

13. Firat, M., De Meyere,* J., Martagan, T., Genga, L. (2022) Optimizing the workload of production units of a make-to-order manufacturing system. Computers and Operations Research, 138(2), 10 p., 105530. https://doi.org/10.1016/j.cor.2021.105530

14. Peeters,* K., Adan J., Hundscheid,* B., Martagan, T., Adan I. (2022) Online Product Allocation in Poultry Batchers with Lookahead. Computers and Industrial Engineering, 165, 16 p., 107875. https://doi.org/10.1016/j.cie.2021.107875

15. Peeters,*K., Adan, I., Martagan, T. (2022) Throughput Control and Revenue Optimization of a Poultry Product Batcher. IISE Transactions, 54:9, 845-857, https://doi.org/10.1080/24725854.2021.1966556   

16. Martagan, T., Akcay, A., Koek,* M., Adan, I. (2021) Optimal Production Decisions in Biopharmaceutical Fill-and-Finish Operations. IISE Transactions,  53:2, 149-163. https://doi.org/10.1080/24725854.2020.1770902

    • Featured in the Industrial Engineer Magazine, Institute of Industrial Engineers, 2020. 

17. Martagan, T., Koca,* Y., Adan, I., van Ravenstein⁺, B., Baaijens⁺, M., Repping⁺, O. (2021) Operations Research Improves Biomanufacturing Efficiency at MSD Animal Health. INFORMS Journal on Applied Analytics, 51(2) 150-163.  https://doi.org/10.1287/inte.2020.1054

    • Finalist of 2019 INFORMS Decision Analysis Society Excellence in Practice Award.

    • Finalist of 2019 EURO Excellence in Practice Award. 

18.  Dang, V., Singh,* N.,  Adan, I., Martagan, T., Sande,* D. (2021) Scheduling heterogeneous multi-load AGVs with battery constraints. Computers and Operations Research, 136, p. 105517. https://doi.org/10.1016/j.cor.2021.105517

19.  Dang, Q-V., van Diessen,* T. F. H., Martagan, T. G.,  Adan, I. J. B. F. (2021) A Matheuristic for Parallel Machine Scheduling with Tool Replacements. European Journal of Operational Research, 291(2): 640-660. https://doi.org/10.1016/j.ejor.2020.09.050

20. Martagan, T., Krishnamurthy, A., Leland⁺, P. (2020). Managing Trade-offs in Protein Manufacturing: How much to waste? Manufacturing & Service Operations Management, 22(2): 223-428. https://doi.org/10.1287/msom.2018.0740

21. Martagan, T., Limon, Y., Krishnamurthy, A., Foti⁺, T., Leland⁺, P. (2019) Aldevron Accelerates Growth Using Operations Research in Biomanufacturing. INFORMS Journal on Applied Analytics, 49(2): 137-153. https://doi.org/10.1287/inte.2018.0984

22. Martagan, T., Krishnamurthy, A., Leland⁺, P., Maravelias, C. (2018). Performance Guarantees and Optimal Purification Decisions for Engineered Proteins. Operations Research, 66(1): 18-41. https://doi.org/10.1287/opre.2017.1661

    • Winner of the 2016 POMS Applied Research Challenge.

    • Finalist of the 2015 M&SOM Student Paper Competition. 

23. Martagan, T., Krishnamurthy, A., Leland⁺, P., Maravelias, C. (2016). Optimal Purification Decisions for Engineer-to-Order Proteins at Aldevron. Production and Operations Management, 25(12): 2003-2005. https://doi.org/10.1111/poms.1_12637

24. Martagan, T., Krishnamurthy, A., Maravelias, C. (2016). Optimal Condition-Based Harvesting Policies for Biomanufacturing Operations with Failure Risks. IISE Transactions, 48(5): 440-461. https://doi.org/10.1080/0740817X.2015.1101523

    • Featured in the Industrial Engineer Magazine, Institute of Industrial Engineers, 2016. 

25.  Martagan, T., Eksioglu, B. (2013). Game Theoretic Analysis of an Inventory Problem with Product Substitution, Random Yield and Stochastic Demand. International Journal of Inventory Research, Vol. 2, pp.27-43. https://doi.org/10.1504/IJIR.2013.058339

Refereed Conference Proceedings (ISI-Indexed)

26. Singh*, N. Didden*, J., Akcay. A., Martagan, T., Adan, I. 2023. Simulation-based AGV management with a linear dispatching rule. Proceedings of the Winter Simulation Conference, pp. 1960-1971.

27. Dang, V., Martagan, T., Adan, I., Kleinlugtenbeld, J. 2022. Order release strategies for a collaborative order-picking system. Proceedings of the Winter Simulation Conference.

28. Singh, N., Herps, K., Martagan, T., and Adan, I.  2019. Simulation-based performance evaluation of a manufacturing facility with vertical AS/RS. Proceedings of the Winter Simulation Conference.

29. Peeters, K., Adan, I., and Martagan, T.  2019. Throughput control and give-away minimization of a poultry product batcher. Proceedings of the Winter Simulation Conference.

30. Hundscheid, B. H. H., Peeters, K., Adan, J., Martagan, T., and Adan, I. 2019.  A hybrid genetic algorithm for the k-bounded semi-online bin covering problem in batching machines. Proceedings of the Winter Simulation Conference. 

31. Wang, B., Xie, W., Martagan, T., Akcay, A., and Corlu, C. G. 2019. Stochastic simulation model development for biopharmaceutical production process risk analysis and stability control. Proceedings of the Winter Simulation Conference.

32. Akçay, A., Martagan, T.,  Corlu, C. 2018. Risk Assessment in Pharmaceutical Supply Chains under Input-Model Uncertainty. Proceedings of the Winter Simulation Conference.

33. Akcay, A., Martagan, T. 2017. Simulation-Based Production Planning for Engineer-to-Order Systems with Random Yield. Proceedings of the Winter Simulation Conference.

34.  Peeters, K., Martagan, T., Adan, I., Cruysen, P.  2017. Control and Design of the Fillet Batching Process in a Poultry Processing Plant. Proceedings of the Winter Simulation Conference.

35. Akcay, A., Martagan, T. 2016. Stochastic Simulation under Input Uncertainty for Contract-Manufacturer Selection in the Pharmaceutical Industry. Proceedings of the Winter Simulation Conference.

36.  T, Martagan and A. Krishnamurthy, 2015. Stochastic Optimization of Protein Purification Operations. Proceedings of the 2015 Industrial and Systems Engineering Research Conference, Nashville, TN.

37. T. Martagan and A. Krishnamurthy, 2013.  Condition-based Harvesting Policies for Upstream Bioreactor Operations Subject to Batch Failures. Proceedings of the 2013 Industrial and Systems Engineering Research Conference, San Juan, PR.

38. Martagan, A. Krishnamurthy, 2012. Control and Optimization of Bio-processes using Markov Decision Processes. Proceedings of the 2012 Industrial and Systems Engineering Research Conference, Orlando, FL.

39. Martagan, T., B. Eksioglu, S. Eksioglu, A. Greenwood. 2009. A Simulation Model of Port Operations during Crisis Conditions. Proceedings of the 2009 Winter Simulation Conference. Piscataway, New Jersey: Institute of Electrical & Electronics Engineers.