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Publication

Yoshihiro TOHYAMA, M.D., Ph.D.

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論文 (英文)

Tohyama Y, Mück-Šeler D, Diksic M. Acute flesinoxan treatment produces a different effect on rat brain serotonin synthesis than chronic treatment: An alpha-methyl-l-tryptophan autoradiographic study. Neurochem Int. 2007 Dec;51(8):486-95.

Tohyama Y, Sikiric P, Diksic M. Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements. Life Sci. 2004 Dec 3;76(3):345-57.

Tohyama Y, Yamane F, Fikre Merid M, Blier P, Diksic M. Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study. J Neurochem. 2002 Mar;80(5):788-98.

Tohyama Y, Takahashi S, Merid MF, Watanabe A, Diksic M. The inhibition of tryptophan hydroxylase, not protein synthesis, reduces the brain trapping of alpha-methyl-L-tryptophan: an autoradiographic study. Neurochem Int. 2002 Jun;40(7):603-10.

Tohyama Y, Yamane F, Merid MF, Diksic M. Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan. Eur Neuropsychopharmacol. 2001 Jun;11(3):193-202

Tohyama Y, Sako K, Yonemasu Y. Hypothermia attenuates hyperglycolysis in the periphery of ischemic core in rat brain Exp. Brain Res. (1998) 122: 333-338

Tohyama Y, Sako K, Yonemasu Y. Hypothermia attenuates the activation of protein kinase C in focal ischemic rat brain: dual autoradiographic study of [3H]phorbol 12,13-dibutyrate and iodo[14C]antipyrine Brain Research, 782 (1-2) (1998) 348-351

Tohyama Y, Sako K, Yonemasu Y. Protein Kinase C in Focal Ischemic Rat Brain: Dual Autoradiographic Analysis of [14C]iodoantipyrine (IAP) and [3H] phorbol-12, 13-dibutyrate (PDBu) Brain Res. 750 (1997) 155-160

Tohyama Y, Sako K, Daita G, Yonemasu Y, Shuke N, Aburano T. Dissociation of 99mTc-ECD and 99mTc-HMPAO Distributions in Herpes Simplex Encephalitis Child's Nervous System, 1997 13: 352-355

Nguyen KQ, Tohyama Y, Watanabe A, Hasegawa S, Skelin I, Diksic M. Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats. Neurochem Int. 2009;54(3-4):161-71.

Watanabe A, Nakai A, Tohyama Y, Nguyen KQ, Diksic M. Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nucl Med Biol. 2006 Apr;33(3):325-32.

Dobson C, Tohyama Y, Diksic M, Hamel E. Effects of Acute or Chronic Administration of Anti-migraine Drugs sumatriptan and zolmitriptan on Serotonin Synthesis in the Rat Brain Cephalalgia. 2004 Jan;24(1):2-11.

Kimura T, Sako K, Tohyama Y, Aizawa S, Yoshida H, Aburano T, Tanaka K, Tanaka T. Diagnosis and treatment of progressive space-occupying radiation necrosis following stereotactic radiosurgery for brain metastasis: value of proton magnetic resonance spectroscopy. Acta Neurochir (Wien). 2003 Jul;145(7):557-64

Watanabe A, Tohyama Y, Nguyen KQ, Hasegawa S, Debonnel G, Diksic M. Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. J Neurochem. 2003 Apr;85(2):469-75.

Yamane F, Tohyama Y, Diksic M. Continuous ethanol administration influences rat brain 5-hyroxytrytamine synthesis non-umiformly: alpha-[14C]methyl-L-trytophan autoradiographic measurements.. Alcohol Alcohol. 2003 Mar-Apr;38(2):115-20.

Diksic M, Tohyama Y, Takada A. Brain net unidirectional uptake of alpha-[14c]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp. Neurochem Res. 2000 Dec;25(12):1537-46.

Yamane F, Tohyama Y, Diksic M. Acute and chronic d-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: An autoradiographic study Neurochem Res, 1999 Dec, 24 (12), 1611-1620

Kimura T, Sako K, Tohyama Y, Hodozuka A. Bow Hunter's stroke caused by simultaneous occlusion of both vertebral arteries. Acta Neurochir (Wien). 1999;141(8):895-6.

Kimura T, Sako K, Tohyama Y, Yonemasu Y. Trigeminal neuralgia caused by compression from petrosal vein transfixing the nerve. Acta Neurochir (Wien) 1999;141(4):437-8

Sugimura T, Sako K, Tohyama Y, Yonemasu Y. Consecutive in vivo measurement nitric oxide in transient forebrain ischemic rat under normothermia and hypothermia Brain Res. 808 (1998) 313-316

著書（英文）

M. Diksic and Y. Tohyama Brain Serotonin Synthesis Measured with 14C- and 11C-Labelled α-Methyl-L-Tryptophan. In U. Pleiss and R. Voges (eds): Synthesis and Applications of Isotopically Labelled Componds vol.7, John Wiley & Sons Inc, United States, 2000:576-579.

Abstracts（英文）

Tohyama Y, Sako K, Sugimura T, Nakagawara J, Kuge Y, Tamaki N. Discrepancy between in vivo and in vitro iomazenil bindings in a rat model of focal cerebral ischemia J Cereb Blood Flow Metab , xx, Sxx, 2007 XXIIIrd International Symposium on Cerebral Blood Flow, Metabolism, and Function & VIIIth International Conference on Quantification of Brain Function with PET May 20 - 24, 2007 Osaka, Japan, Abstract PP7-7U

Tohyama Y． TRANSFER RATE INDEX AS A NEW PARAMETER OF [201TL]-SPECT IN BRAIN TUMORS J Cereb Blood Flow Metab , 25, S331, 2005 XXIInd International Symposium on Cerebral Blood Flow, Metabolism, and Function& VIIth International Conference on Quantification of Brain Function with PET June 7 - 11, 2005 Amsterdam, The Netherlands, Abstract 365

Tohyama Y, Sako K, Sugimura T. Discrepancy of iomazenil bindings between in vivo and in vitro in acute rat brain 5^th World Stroke Congress June 23-26, 2004 Vancouver B.C., Canada, Abstracts, 127

Y. Tohyama, F. Yamane, M. Fikre Merid, M. Diksic Effect of 5-HT1B agonists on regional serotonin synthesis in rat brain J Cereb Blood Flow Metab , 21, Suppl. 1, S248, 2001

Y. Tohyama, F. Yamane, M. Diksic Effect of 5-HT1A antagonist WAY100635 on regional serotonin synthesis in rat brain J Cereb Blood Flow Metab , 19, Suppl. 1, S319, 1999

Y. Tohyama, K. Sako, Y. Yonemasu Protein Kinase C in Focal Ischemic Rat Brain: Dual Autoradiographic Analysis of [14C]iodoantipyrine and [3H] phorbol 12, 13-dibutyrate J Cereb Blood Flow Metab , 17, Suppl. 1, S532, 1997

Y. Tohyama, K. Sako, Y. Yonemasu Effect of moderate hypothermia on ischemic brain damage and cerebral glucose metabolism J Cereb Blood Flow Metab , 15, Suppl. 1, S192, 1995

Diksic M, Tohyama Y, Firke Merid M Cycloheximide, an inhibitor of protein synthesis, does not influence brain trapping of alpha-[14C]methyl-L-tryptophan. Proc. Int. Chem. Congress of Pacific Basin Soc. Honolulu Dec. 14-19, Abstract 50, American Chem. Soc., Washington DC.

F. Yamane, Y. Tohyama, M. Diksic Chronic ethanol exposure enhances brain 5-HT synthesis in rat brain J Cereb Blood Flow Metab , 19, Suppl. 1, S326, 1999

K. Sako, T. Ohasa, Y. Tohyama, K. Ogawa Sequential changes of protein kinase c expression after focal cerebral ischemia in the rat J Cereb Blood Flow Metab , 19, Suppl. 1, S548, 1999

T. Sugimura, Y. Tohyama, K. Sako, Y. Yonemasu Consecutive in vivo measurement of brain nitric oxide in the forebrain ischemic rats under normothermia and hypothermia J Cereb Blood Flow Metab , 17, Suppl. 1, S679, 1997

J. Sato, N. Syuke, Y. Ishikawa, T. Takahashi, Y. Saito, H. Takei, T. Aburano, Y. Tohyama, K. Sako, Y. Yonemasu, M. Morimoto, K. Saito Discordant brain distribution between Tc-99m-ECD and Tc-99m-HMPAO: Assessment with Tc-99m-ECD dynamic SPECT J Nuc Med. 36 (Supp), S244, 1995

論文 (日本語)

遠山義浩，小林延光，中川原譲二，伊東民雄，佐藤憲市，中村博彦，高橋正昭 脳腫瘍のRetention indexにおける時間の影響と²⁰¹TL SPECTの新たな解析の試み 第16回北海道脳PET, SPECT 研究会記録集(16)54-56，2008

遠山義浩，小林延光，杉山拓，伊東雅基，村井宏，馬渕正二 ニカルジピン持続脳槽灌流療法のスパズム予防効果と灌流液のdeliveryを考慮した手術工夫 脳卒中の外科（増刊号）35(suppl) 脳血管攣縮（23）81-85，2007

遠山義浩，佐古和廣 ¹²³I-iomazenil SPECTの2 point Gjedde-Patlak および Logan analysis 第15回北海道脳PET, SPECT 研究会記録集(15)52-55，2007

遠山義浩，杉山拓，伊東雅基，村井宏，馬渕正二 脳血管攣縮の予防のためのnicardipine持続脳槽灌流療法の効果と灌流液のdeliveryを考慮した手術における工夫 脳卒中の外科（35）174-180，2007

遠山義浩, Diksic M Pharmacological Effects on Serotonin Synthesis in Rat Brain; a-[¹⁴C]Methyl-L-Tryptophan Autoradiographic Method 第14回北海道脳PET, SPECT 研究会記録集(14)29-35，2006

遠山義浩，杉山拓，村井宏，馬渕正二,松尾公弘 脳腫瘍における201Tl のtransfer rate index （201Tl SPECT の新しい指標として） 第13回北海道脳PET, SPECT 研究会記録集(13)48-54，2005

遠山義浩，佐古和廣，米増祐吉，秀毛範至，油野民雄，石川幸雄，佐藤順一 脳腫瘍におけるDynamic SPECTによる201TlCl, 99mTc-DTPAの動態の検討 北海道脳SPECT研究会記録集(4)66-68，1996

遠山義浩，田中達也，藤田力，高野勝信，関口ふく子，國本雅之，米増祐吉，千葉茂，武藤福保，宮本晶恵，伊藤善也術中脳波にて焦点性発作重積状態を呈した皮質下腫瘍の3例 てんかんをめぐって 北海道てんかん懇話会誌（12）106-111，1991

遠山義浩，代田剛，中井啓文，田中達也，大神正一郎，米増祐吉，村岡俊二，岡崎慎哉 松果体部cavernous angiomaの1例 小児の脳神経16（3）173-177，1991

遠山義浩，田中達也，藤田力，中井啓文，米増祐吉，牧野吉眞 難治性複雑部分発作を呈したhemangioma calcificansの一手術例 てんかんをめぐって 北海道てんかん懇話会誌（11）99-107，1990

川崎和凡, 代田剛, 遠山義浩, 前田高宏, 米増祐吉, 竹田津原野 腹腔カテーテルのスリット部の屈曲によってシャント閉塞を来した1例 小児の脳神経, 23(1) : 23-27, 1998.

秀毛範至，高塩哲也，山本和香子，片田竜司，油野民雄，佐藤順一，石川幸雄，杉村敏秀，遠山義浩，佐古和廣，田中達也，米増祐吉 直接積分線形最小２乗法によるBrain Perfusion Indexの算出 北海道脳SPECT研究会記録集(5)11-14，1997

佐古和廣，遠山義浩，川田佳克，米増祐吉，秀毛範至，油野民雄 Dynamic SPECTによる201TlCl, 99mTc-DTPAの悪性脳腫瘍，髄膜種における動態の検討 CI研究（18）125-130，1996

代田剛，國本雅之，橋詰清隆，川田佳克，遠山義浩，米増祐吉 下垂体腺腫の増殖能と蝶形骨洞経由手術後の内分泌値の関連について ホルモンと臨床（43）46-50，1995

牧野憲一，高村春雄，後藤聰，上山博康，小林延光，由良茂貴，遠山義浩，能條建 脳血管攣縮予知のためのAcetazolamide (Diamox)負荷123I-IMP SPECTの有効性について パーヒューザミン研究会記録集（9）23-26，1993

牧野憲一，高村春雄，後藤聰，上山博康，小林延光，由良茂貴，遠山義浩，能條建，増田安彦，安部直之 123I-IMP SPECTによる局所脳血流の定量的測定法の経験 北海道脳SPECT研究会記録集(1)6-9，1993

佐古和廣，遠山義浩，瀧澤克己，藤田力，大神正一郎，米増祐吉，竹井秀敏 眼窩内海綿状血管腫の診断における99mTc-RBCscintigraphyの有用性 CI研究14（3）257-262，1992

佐古和廣，程塚明，相沢希，木村輝雄，遠山義浩，中井啓文，岡崎慎哉，米増祐吉，竹井秀敏 In vivo, in vitro オートラディオグラフィー法によるintra-arterial chemotherapyの問題点の検討 CT研究13（3）269-274，1991

高橋悟，宮本晶恵，伊藤淳一，沖潤一，長和彦，遠山義浩，田中達也，村岡俊二 けいれん発作重積で発症した悪性神経膠腫の幼児例 てんかんをめぐって 北海道てんかん懇話会誌（12）101-105，1991

田中達也，藤田力，高野勝信，遠山義浩，米増祐吉 旭川医科大学脳神経外科における難治性てんかんの手術 てんかんをめぐって 北海道てんかん懇話会誌（12）130-138，1991

代田剛，米増祐吉，高野勝信，遠山義浩，泉直人，安藤政克 op’-DDDを投与したCushing病の一剖検例-組織学的検討- ホルモンと臨床38（12）1267-1271，1990