Resume
ACADEMIC EDUCATION
October 2002 - June 2007: Diploma in Molecular Biology & Genetics, Democritus University of Thrace.
October 2007 - September 2008: MRes in Computational Biology, University of York.
October 2009 - awarded in December 2011: MPhil in Pharmaceutical Sciences, School of Pharmacy, University of Manchester.
January 2011 - January 2016: PhD in Pharmaceutical Sciences (Biomolecular Spectroscopy & Computational Drug Design group), Department of Pharmaceutical Chemistry, University of Athens & Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
February 2016 - July 2018: Postdoctoral Researcher at Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
August 2018 - date: Research Scientist at Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague & at Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
RESEARCH INTERESTS: Molecular Dynamics simulations, Protein Structure Prediction, Nuclear Magnetic Resonance, Structure- and Ligand- based Drug Design, Machine Learning, Chemoinformatics.
LANGUAGES: Greek(mother tongue), English (professional working experience), Czech (advanced), German (intermediate), French (beginner).
PROGRAMMING LANGUAGES: Python/Tk, Java, Tcl/Tk, Perl, C/C++.
SCRIPTING & MARKUP LANGUAGES: Unix shell, R, MATLAB, MySQL, LaTeX, HTML.
PUBLICATIONS
L. Xie, T. Evangelidis, L. Xie, P.E. Bourne 2011, "Drug Discovery Using Chemical Systems Biology: Weak inhibition of multiple kinases may contribute to the anti-cancer effect of Nelfinavir". PLoS Comput Biol, Vol. 7, No. 4. (28 April 2011).
T. Evangelidis , P.E. Bourne, L. Xie, L. Xie, "An integrated workflow for proteome-wide off-target identification and polypharmacology drug design", (2012) Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 PP. 32 - 39
Krypotou, Lambrinidis G*, Evangelidis T*, Mikros E, Diallinas G., "Modelling, substrate docking and mutational analysis identify residues essential for function and specificity of the major fungal purine transporter AzgA". Mol Microbiol. 2014 Jul;93(1):129-45. * equal contribution
Gkeka P*, Evangelidis T*, Pavlaki M, Lazani V, Christoforidis S, Agianian B, Cournia Z., "Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant". PLoS Comput Biol. 2014 Oct 23;10(10). * equal contribution
Gournas C, Evangelidis T, Athanasopoulos A, Mikros E, Sophianopoulou V., "The Aspergillus nidulans proline permease as a model for understanding the factors determining substrate binding and specificity of fungal amino acid transporters.", J Biol Chem. 2015 Mar 6;290(10):6141-55
Krypotou E, Evangelidis T, Bobonis J, Pittis AA, Gabaldón T, Scazzocchio C, Mikros E, Diallinas G., "Origin, diversification and substrate specificity in the family of NCS1/FUR transporters". Mol Microbiol. 2015 Jun;96(5):927-50
Daniilides K, Lougiakis N, Evangelidis T, Kostakis IK, Pouli N, Marakos P, Mikros E, Skaltsounis AL, Bach S, Baratte B, Ruchaud S, Karamani V, Papafotika A, Christoforidis S, Argyros O, Kouvari E, Tamvakopoulos C. "Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme". Anticancer Agents Med Chem. 2017;17(7):990-1002.
Evangelidis T, Nerli S, Novacek J, Brereton A, Karplus A, Dotas R, Venditti V, Sgourakis N, Tripsianes K. "Automated NMR resonance assignments and structure determination using a minimal set of 4D spectra”. Nat Commun. 2018 Jan 26;9(1):384.
Botou M, Lazou P, Papakostas K, Lambrinidis G, Evangelidis T, Mikros E, Frillingos S. "Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli". Mol Microbiol. 2018 Apr;108(2):204-219
Marcos E, Chidyausiku TM, McShan AC, Evangelidis T, Nerli S, Carter L, Nivón LG, Davis A, Oberdorfer G, Tripsianes K, Sgourakis NG, Baker D, "De novo design of a non-local β-sheet protein with high stability and accuracy". Nat Struct Mol Biol. 2018 Oct 29.