Ha Lab: Single-Molecule Biophysics & Genome Maintenance

We have been affiliated with Howard Hughes Medical Institute since 2005. Since August 2023, we are part of Program in Cellular and Molecular Medicine at Boston Children's Hospital, and Department of Pediatrics and Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. We share (almost) everything with our sister lab of Dr. Sua Myong. We are currently located on the 2nd floor of Center for Life Science Building (3 Blackfan Circle, Boston MA 02115). Publications search on pubmed Taekjip Ha's Google Scholar's profile

Useful reading

CRISPR & DNA repair:

PMID 32527834 (Science 2020)PMID 41343630 (Science 2025)

3D genome mechanics:

PMID 33328628 (Nature 2021)PMID 40335690 (Nature 2025)

Single molecule techniques:

PMID 38513010 (Science 2024)PMID 38772370 (Cell 2024)

Genomic caretakers:

PMID 25883358 (Science 2015)PMID 36274095 (Nature Comms 2022)

Check out our recent paper on homology search mechanisms in mammalian cells (link)!

Check out our recent paper on determining single molecule force loading rates in living cells (link)!

A primer article on single molecule fluorescence resonance energy transfer (pdf).

All-inclusive package for single molecule FRET (link).

We develop and use single molecule measurement technologies to study genome maintenance in vitro and in living cells.

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