Stavros Zanos, MD PhD
Stavros Zanos, MD PhD
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Stavros Zanos is a physician-scientist living in New York. He works in the fields of cardiovascular physiology,neuromodulation, neuroimmunology, and translational medicine, including preclinical and early-stage clinical research; he is also a medical educator.
Stavros Zanos is a physician-scientist living in New York. He works in the fields of cardiovascular physiology,neuromodulation, neuroimmunology, and translational medicine, including preclinical and early-stage clinical research; he is also a medical educator.
His expertise includes:
His expertise includes:
Cardiovascular and translational medicine, including cardivascular medicine and physiology, neurocardiology, autonomic and immunologic dysfunction in cardiovascular diseases, chronic inflammation, cardiovascular biomarkers, animal models of neurological and cardiovascular diseases, early stage clinical trials in cardiology.
Cardiovascular and translational medicine, including cardivascular medicine and physiology, neurocardiology, autonomic and immunologic dysfunction in cardiovascular diseases, chronic inflammation, cardiovascular biomarkers, animal models of neurological and cardiovascular diseases, early stage clinical trials in cardiology.
Neuroscience, neuromodulation, and neuroimmunology, including systems and circuit neuroscience, neurophysiology, neuroanatomy, autonomic neuroscience,brain stimulation, brain-computer interfaces, neural engineering, neural interfaces, vagus nerve stimulation, focused ultrasound, immunomodulation, peripheral neuroimmunology, neuroinflammation.
Neuroscience, neuromodulation, and neuroimmunology, including systems and circuit neuroscience, neurophysiology, neuroanatomy, autonomic neuroscience,brain stimulation, brain-computer interfaces, neural engineering, neural interfaces, vagus nerve stimulation, focused ultrasound, immunomodulation, peripheral neuroimmunology, neuroinflammation.
Medical education, including cardiovascular physiology, and medical neuroscience.
Medical education, including cardiovascular physiology, and medical neuroscience.
After obtaining his MD degree from Aristotle University School of Medicine, in Thessaloniki, Greece, Stavros trained in internal medicine and cardiology at the Papageorgiou General Hospital, in Thessaloniki, and Onassis Cardiac Surgery Center, in Athens, Greece, respectively, and earned a PhD in Physiology & Biophysics/Neuroscience from the University of Washington, in Seattle, WA, where he also served as senior fellow and instructor.
After obtaining his MD degree from Aristotle University School of Medicine, in Thessaloniki, Greece, Stavros trained in internal medicine and cardiology at the Papageorgiou General Hospital, in Thessaloniki, and Onassis Cardiac Surgery Center, in Athens, Greece, respectively, and earned a PhD in Physiology & Biophysics/Neuroscience from the University of Washington, in Seattle, WA, where he also served as senior fellow and instructor.
He joined Northwell Health and the Feinstein Institute for Medical Research (FIMR) as assistant professor in 2017.
He joined Northwell Health and the Feinstein Institute for Medical Research (FIMR) as assistant professor in 2017.
Stavros is associate professor at the Zucker School of Medicine at Hofstra/Northwell, where he teaches neuroscience and cardiovascular physiology. He is adjunct faculty at the University of Washington and at the New York Institute of Technology.
Stavros is associate professor at the Zucker School of Medicine at Hofstra/Northwell, where he teaches neuroscience and cardiovascular physiology. He is adjunct faculty at the University of Washington and at the New York Institute of Technology.
Stavros is currently associate professor at FIMR, where he heads the Translational Neurophysiology (TNP) lab. The TNP lab investigates the regulation of immunity and physiological homeostasis by the autonomic nervous system, develops methods to deliver precision autonomic neuromodulation and investigates disorders with an inflammatory and metabolic component, especially diseases of the heart, lung and vessels.
Stavros is currently associate professor at FIMR, where he heads the Translational Neurophysiology (TNP) lab. The TNP lab investigates the regulation of immunity and physiological homeostasis by the autonomic nervous system, develops methods to deliver precision autonomic neuromodulation and investigates disorders with an inflammatory and metabolic component, especially diseases of the heart, lung and vessels.
More specifically, the lab has launched and developed 2 major research programs, supported by several grants and resulting in multiple high-impact publications: Bioelectronic Medicine in Cardiology, and Precision Vagal Neuromodulation.
More specifically, the lab has launched and developed 2 major research programs, supported by several grants and resulting in multiple high-impact publications: Bioelectronic Medicine in Cardiology, and Precision Vagal Neuromodulation.
Program at a Glance:
Program at a Glance:
Autonomic Neuromodulation in Cardiology
Autonomic Neuromodulation in Cardiology
Autonomic neuromodulation is an emerging approach to treating chronic diseases by stimulating neural circuits that control inflammation, immunity and metabolism. Cardiovascular diseases (CVDs) such as heart failure, hypertension, and arrhythmias are associated with immune and metabolic dysfunction, and are potential candidates for neuromodulation treatments.
Autonomic neuromodulation is an emerging approach to treating chronic diseases by stimulating neural circuits that control inflammation, immunity and metabolism. Cardiovascular diseases (CVDs) such as heart failure, hypertension, and arrhythmias are associated with immune and metabolic dysfunction, and are potential candidates for neuromodulation treatments.
We are among the first to have developed clinically-relevant neuromodulation approaches, especially electrical stimulation and focused ultrasound stimulation of autonomic nerves to treat CVDs, by targeting specific neural circuits involved in key immune and metabolic pathogenic mechanisms. Our "Autonomic Neuromodulation in Cardiology" program combines studies of neuroimmune and neurometabolic dysfunction in CVDs with neuromodulation of neural circuits that regulate immune and metabolic processes to develop treatments of CVDs.
We are among the first to have developed clinically-relevant neuromodulation approaches, especially electrical stimulation and focused ultrasound stimulation of autonomic nerves to treat CVDs, by targeting specific neural circuits involved in key immune and metabolic pathogenic mechanisms. Our "Autonomic Neuromodulation in Cardiology" program combines studies of neuroimmune and neurometabolic dysfunction in CVDs with neuromodulation of neural circuits that regulate immune and metabolic processes to develop treatments of CVDs.
For more details check out the following peer-reviewed papers:
For more details check out the following peer-reviewed papers:
Pulmonary arterial hypertension: the case for a bioelectronic treatment (Bioelectronic Medicine 2019)
Pulmonary arterial hypertension: the case for a bioelectronic treatment (Bioelectronic Medicine 2019)
Focused ultrasound neuromodulation of the spleen improves pulmonary hypertension (Circulation Research 2024)
Focused ultrasound neuromodulation of the spleen improves pulmonary hypertension (Circulation Research 2024)
Vagus nerve stimulation modulates distinct acetylcholine receptors on B cells and limits the germinal center response (Science Advances 2023)
Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans (Brain Stimulation 2023)
Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine (Nature Biomedical Engineering 2023)
Program at a Glance:
Program at a Glance:
Precision Vagal Neuromodulation
Precision Vagal Neuromodulation
The vagus nerve (VN), with its thousands of nerve fibers, physically connects the brain with most visceral organs, and transfers information used by the autonomic nervous system in the control of physiological homeostasis. Vagus nerve stimulation (VNS), by activating vagal fibers, partially restores autonomic dysfunction that is pathogenically implicated in chronic diseases. However, VNS usually results in relatively uncontrolled activation of vagal fibers, sometimes leading to side effects. Likewise, typical VNS therapies may be failing to activate other neural pathways, whose activation could offer additional therapeutic options.
The vagus nerve (VN), with its thousands of nerve fibers, physically connects the brain with most visceral organs, and transfers information used by the autonomic nervous system in the control of physiological homeostasis. Vagus nerve stimulation (VNS), by activating vagal fibers, partially restores autonomic dysfunction that is pathogenically implicated in chronic diseases. However, VNS usually results in relatively uncontrolled activation of vagal fibers, sometimes leading to side effects. Likewise, typical VNS therapies may be failing to activate other neural pathways, whose activation could offer additional therapeutic options.
We are among the first to have developed novel approaches and methods for precise and tunable VNS, that allows the targeting of specific vagal fibers and neural pathways using devices placed in the cervical VN. Our "Precision Vagal Neuromodulation" program combines studies of the detailed anatomical organization of the VN, computational modeling of fibers and electrical fields generated by stimulation devices, and neurophysiological investigations in large animals, to develop function- and organ-selective VNS therapies.
We are among the first to have developed novel approaches and methods for precise and tunable VNS, that allows the targeting of specific vagal fibers and neural pathways using devices placed in the cervical VN. Our "Precision Vagal Neuromodulation" program combines studies of the detailed anatomical organization of the VN, computational modeling of fibers and electrical fields generated by stimulation devices, and neurophysiological investigations in large animals, to develop function- and organ-selective VNS therapies.
For more details check out the following peer-reviewed papers:
For more details check out the following peer-reviewed papers:
Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation (Journal of Neuroinflammation 2023)
Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation (Journal of Neuroinflammation 2023)
kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents (Brain Stimulation 2022)
kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents (Brain Stimulation 2022)
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