Stavros Zanos, MD PhD
Stavros Zanos, MD PhD
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Stavros Zanos is a physician-scientist living in New York. He works in the fields of cardiovascular medicine, neurocardiology, neuromodulation, and neuroimmunology, including preclinical and early-stage clinical research; he is also a medical educator.
Stavros Zanos is a physician-scientist living in New York. He works in the fields of cardiovascular medicine, neurocardiology, neuromodulation, and neuroimmunology, including preclinical and early-stage clinical research; he is also a medical educator.
Expertise
Expertise
Cardiovascular and translational medicine, including cardiovascular medicine and physiology, neurocardiology, cardiovascular biomarkers, animal models of cardiovascular disease, early stage clinical trials in cardiology.
Cardiovascular and translational medicine, including cardiovascular medicine and physiology, neurocardiology, cardiovascular biomarkers, animal models of cardiovascular disease, early stage clinical trials in cardiology.
Neuroimmunology, including neuroinflammation, peripheral neuroimmunology, cardiovascular immunology, chronic inflammation, immunomodulation.
Neuroimmunology, including neuroinflammation, peripheral neuroimmunology, cardiovascular immunology, chronic inflammation, immunomodulation.
Neuroscience and neuromodulation, including systems and circuit neuroscience, neurophysiology methods in humans and animals, neuroanatomy, autonomic neuroscience, brain stimulation, brain-computer interfaces, neural engineering, neural interfaces, vagus nerve stimulation, focused ultrasound neuromodulation.
Neuroscience and neuromodulation, including systems and circuit neuroscience, neurophysiology methods in humans and animals, neuroanatomy, autonomic neuroscience, brain stimulation, brain-computer interfaces, neural engineering, neural interfaces, vagus nerve stimulation, focused ultrasound neuromodulation.
Medical education, including cardiovascular physiology, and medical neuroscience.
Medical education, including cardiovascular physiology, and medical neuroscience.
Resume
Resume
After obtaining his MD degree from Aristotle University School of Medicine, in Thessaloniki, Greece, Stavros trained in internal medicine and cardiology at the Papageorgiou General Hospital, in Thessaloniki, and Onassis Cardiac Surgery Center, in Athens, Greece, respectively, and earned a PhD in Neurobiology & Biophysics from the University of Washington, in Seattle, WA, where he also served as senior fellow and instructor.
After obtaining his MD degree from Aristotle University School of Medicine, in Thessaloniki, Greece, Stavros trained in internal medicine and cardiology at the Papageorgiou General Hospital, in Thessaloniki, and Onassis Cardiac Surgery Center, in Athens, Greece, respectively, and earned a PhD in Neurobiology & Biophysics from the University of Washington, in Seattle, WA, where he also served as senior fellow and instructor.
He joined Northwell Health and the Feinstein Institute for Medical Research to head the Translational Neurophysiology laboratory. Stavros is associate professor at the Zucker School of Medicine at Hofstra/Northwell. He is adjunct faculty at the University of Washington and at the New York Institute of Technology.
He joined Northwell Health and the Feinstein Institute for Medical Research to head the Translational Neurophysiology laboratory. Stavros is associate professor at the Zucker School of Medicine at Hofstra/Northwell. He is adjunct faculty at the University of Washington and at the New York Institute of Technology.
Stavros's research group investigates the regulation of immunity and physiological homeostasis by the autonomic nervous system, investigates the neuroimmune pathogenesis of disorders with an inflammatory and metabolic component, especially diseases of the heart, lung and vessels, and develops methods to deliver precision autonomic neuromodulation to treat immune dysfunction in cardiovascular diseases.
Stavros's research group investigates the regulation of immunity and physiological homeostasis by the autonomic nervous system, investigates the neuroimmune pathogenesis of disorders with an inflammatory and metabolic component, especially diseases of the heart, lung and vessels, and develops methods to deliver precision autonomic neuromodulation to treat immune dysfunction in cardiovascular diseases.
Stavros' research has received support of more than $20M in funding via grants from NIH, DARPA, BARDA, FUS Foundation, GE Research/Healthcare, United Therapeutics Corp., Boston Scientific and Livanova (former Cyberonics), and has resulted in more than 80 publications.
Stavros' research has received support of more than $20M in funding via grants from NIH, DARPA, BARDA, FUS Foundation, GE Research/Healthcare, United Therapeutics Corp., Boston Scientific and Livanova (former Cyberonics), and has resulted in more than 80 publications.
Neuromoimmune Dysfunction and Modulation in Cardiology
Neuromoimmune Dysfunction and Modulation in Cardiology
Autonomic neuromodulation is an emerging approach to treating chronic diseases by stimulating neural circuits that control inflammation, immunity and metabolism. Cardiovascular diseases (CVDs) such as heart failure, hypertension, and arrhythmias are associated with immune and metabolic dysfunction, and are potential candidates for neuromodulation treatments. We are among the first to have developed clinically-relevant neuromodulation approaches, especially electrical stimulation and focused ultrasound stimulation of autonomic nerves to treat CVDs, by targeting specific neural circuits involved in key immune and metabolic pathogenic mechanisms.
Autonomic neuromodulation is an emerging approach to treating chronic diseases by stimulating neural circuits that control inflammation, immunity and metabolism. Cardiovascular diseases (CVDs) such as heart failure, hypertension, and arrhythmias are associated with immune and metabolic dysfunction, and are potential candidates for neuromodulation treatments. We are among the first to have developed clinically-relevant neuromodulation approaches, especially electrical stimulation and focused ultrasound stimulation of autonomic nerves to treat CVDs, by targeting specific neural circuits involved in key immune and metabolic pathogenic mechanisms.
This research program combines studies of neuroimmune and neurometabolic dysfunction in CVDs with neuromodulation of neural circuits that regulate immune and metabolic processes to develop treatments of CVDs.
This research program combines studies of neuroimmune and neurometabolic dysfunction in CVDs with neuromodulation of neural circuits that regulate immune and metabolic processes to develop treatments of CVDs.
For more details check out the following peer-reviewed papers:
For more details check out the following peer-reviewed papers:
- Pulmonary arterial hypertension: the case for a bioelectronic treatment (Bioelectronic Medicine 2019)
- Focused ultrasound neuromodulation of the spleen improves pulmonary hypertension (Circulation Research 2024)
- Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans (Brain Stimulation 2023)
- Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine (Nature Biomedical Engineering 2023)
Precision Vagal Neuromodulation
Precision Vagal Neuromodulation
The vagus nerve (VN), with its thousands of nerve fibers, physically connects the brain with most visceral organs, and transfers information used by the autonomic nervous system in the control of physiological homeostasis. Vagus nerve stimulation (VNS), by activating vagal fibers, partially restores autonomic dysfunction that is pathogenically implicated in chronic diseases. However, VNS usually results in relatively uncontrolled activation of vagal fibers, sometimes leading to side effects. Likewise, typical VNS therapies may be failing to activate other neural pathways, whose activation could offer additional therapeutic options.
The vagus nerve (VN), with its thousands of nerve fibers, physically connects the brain with most visceral organs, and transfers information used by the autonomic nervous system in the control of physiological homeostasis. Vagus nerve stimulation (VNS), by activating vagal fibers, partially restores autonomic dysfunction that is pathogenically implicated in chronic diseases. However, VNS usually results in relatively uncontrolled activation of vagal fibers, sometimes leading to side effects. Likewise, typical VNS therapies may be failing to activate other neural pathways, whose activation could offer additional therapeutic options.
We are among the first to have developed novel approaches and methods for precise and tunable VNS, that allows the targeting of specific vagal fibers and neural pathways using devices placed in the cervical VN. This research program combines studies of the detailed anatomical organization of the VN, computational modeling of fibers and electrical fields generated by stimulation devices, and neurophysiological investigations in large animals, to develop function- and organ-selective VNS therapies.
We are among the first to have developed novel approaches and methods for precise and tunable VNS, that allows the targeting of specific vagal fibers and neural pathways using devices placed in the cervical VN. This research program combines studies of the detailed anatomical organization of the VN, computational modeling of fibers and electrical fields generated by stimulation devices, and neurophysiological investigations in large animals, to develop function- and organ-selective VNS therapies.
For more details check out the following peer-reviewed papers:
For more details check out the following peer-reviewed papers:
- Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation (Journal of Neuroinflammation 2023)
- kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents (Brain Stimulation 2022)
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