Welcome to the Shakkottai Lab!

Motor incoordination results in significant disability. The cerebellar ataxias are a group of disorders with an impairment of coordination. These disorders are associated with degeneration of the cerebellum and its associated pathways. Prior to the loss of neurons, neuronal dysfunction contributes to symptoms. We are interested in the nature of this neuronal dysfunction and whether we can improve symptoms or prevent neuronal loss if we understand alterations in neuronal function. We use a combination of single cell electrophysiology, pharmacology and in vivo drug delivery to answer these questions.