Publications

Above are various journal covers that have featured our work!

Recent Publications

2022

Changlin Y, Tian G, Dajac M, Doty A, Wang S, Lee JH, Rahman M, Huang J, Reynolds BA, Sarkisian MR, Mitchell D, Deleyrolle LP. Slow-cycling cells in glioblastoma: a specific population in the cellular mosaic of cancer stem cells. Cancers 2022; 14: 1126.

Shi P, Tian J, Ulm B, Mallinger JC, Khoshbouei H, Deleyrolle LP, Sarkisian MR. Tumor treating fields suppression of ciliogenesis enhances temozolomide toxicity. Front Oncol 2022; 12:837589.

Lee D, Gimple RC, Prager BC, Qiu Z, Wu Q, Daggubati V, Gopalakrishnan J, Sarkisian MR, Raleigh DR, Rich JN. Superenhancer-activation of KLHDC8A drives glioma ciliation and hedgehog signaling. J Clin Invest 2022; Nov 17:e163592.

2021

Shi P, Hoang-Minh LB, Tian J, Cheng A, Basrai R, Kalaria N, Lebowitz JJ, Khoshbouei H, Deleyrolle LP, Sarkisian MR. HDAC6 signaling at primary cilia promotes proliferation and restricts differentiation of glioma cells. Cancers 2021; 13: 1644.

2020

Flores-Toco JA, Luo D, Gopinath A, Sarkisian MR, Campbell JJ, Charo IF, Sing R, Schall TJ, Datta M, Jain RK, Mitchell DA, Harrison JK. CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas. Proc Natl Acad Sci USA 2020; 117: 1129-1138.

2019

Sarkisian MR, Semple-Rowland S. Emerging roles of primary cilia in glioma. Frontiers in Cellular Neuroscience 2019; 13: 55.

2018

Hoang-Minh LB, Dutra-Clarke M, Breunig JJ, Sarkisian MR. Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles. Cilia 2018; 7: 6.

Hoang-Minh LB, Siebzehnrubl FA, Yang C, Suzuki-Hatano S, Dajac K, Loche T, Andrews N, Schmoll M, Patel J, Amin K, Vuong A, Jimenez-Pascual A, Kubulis P, Garrett TT, Moneypenny C, Pacak CA, Huang J, Sayour EJ, Mitchell DA, Sarkisian MR, Reynolds BA, Deleyrolle LP. Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma. The EMBO Journal 2018; 37, e98772. *featured on cover above

Sayour EJ, Grippin A, De Leon G, Stover B, Rahman M, Karachi A, Wummer B, Moore G, Castillo-Caro P, Fredenburg K, Sarkisian MR, Huang J, Deleyrolle LP, Sahay B, Carrera-Justiz S, Mendez-Gomez HR, Mitchell DA. Personalized tumor mRNA loaded lipid nanoparticles prime the systemic and intratumoral milieu for response to cancer immunotherapy. Nano Letters 2018; 18: 6195-6206.

Huang T, Nguyen L, Lin TV, Gong X, Zhang L, Kim GB, Sarkisian MR, Breunig JJ, Bordey A. In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neuroscience Research 2019; 143: 44-52. (epub 2018 May 29)

2016

Hoang-Minh LB, Deleyrolle LP, Nakamura NS, Parker AK, Martuscello RT, Reynolds BA, Sarkisian MR. PCM1 depletion inhibits glioblastoma cell ciliogenesis and increases cell death and sensitivity to temozolomide. Translational Oncology 2016; 9: 392-402.

Ramos RL, Toia AR, Pasternack D, Dotzler T, Cuoco JA, Esposito A, Le M, Parker AK, Goodman JH, Sarkisian MR. Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex. Neuroscience 2016 337: 48-65.

Parker AK, Le MM, Smith TS, Hoang-Minh LB, Atkinson E, Ugartemendia G, Semple-Rowland S, Coleman JE, Sarkisian MR. Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons. Experimental Neurology 2016 282: 119-127.

Guadiana SM, Parker AK, Filho GF, Sequeira A, Semple-Rowland S, Shaw G, Mandel RJ, Foster TC, Kumar A, Sarkisian MR. Type 3 adenylyl cyclase and somatostatin receptor 3 expression persists in aged rat neocortical and hippocampal neuronal cilia. Frontiers in Aging Neuroscience 2016; 8:127.

Hoang-Minh LB, Deleyrolle LP, Ugartemendia G, Futch H, Griffith B, Breunig JJ, De Leon G, Mitchell DA, Semple-Rowland SL, Reynolds BA, Sarkisian MR. Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity and tumorigenesis. Oncotarget 2016; 7: 7029-7043.*featured on cover above

2015

Sarkisian MR, Guadiana SM. Influences of primary cilia on cortical morphogenesis and neuronal subtype maturation. Neuroscientist 2015; 21:136-151. (first published online Apr 16, 2014) *Recommended by Faculty of 1000 http://f1000.com/prime/718358558

2014

Sarkisian MR, Siebzehnrubl D, Hoang-Minh L, Deleyrolle L, Silver DJ, Siebzehnrubl FA, Guadiana SM, Srivinasan G, Semple-Rowland S, Harrison JK, Steindler DA, Reynolds BA. Detection of primary cilia in human glioblastoma. Journal of Neuro-Oncology 2014; 117: 15-24. *featured on cover above

2013

Siebzehnrubl FA, Silver DJ, Tugertimur B, Deleyrolle LP, Siebzehnrubl D, Sarkisian MR, Devers KG, Yachnis AT, Kupper MD, Neal D, Nabilsi NH, Kladde MP, Suslov O, Brabletz S, Brabletz T, Reynolds BA, Steindler DA. The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Molecular Medicine 2013; 5: 1196-1212.

Guadiana SM, Semple-Rowland S, Daroszewski D, Madorsky I, Breunig JJ, Mykytyn K, Sarkisian MR. Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase. The Journal of Neuroscience 2013; 33: 2626-2638.

Sarkisian MR, Arellano JI, Breunig JJ. Primary cilia in cerebral cortex: growth and functions on neuronal and non-neuronal cells. In: Cilia and Nervous System Development and Function. Caspary T, Tucker KL (Eds). Springer, 2013: pp 105-129.

2012

Arellano JI, Guadiana SM, Breunig JJ, Rakic P, Sarkisian MR. Development and distribution of neuronal cilia in mouse neocortex. The Journal of Comparative Neurology 2012; 520: 848-873.

Sarkisian MR, Siebzehnrubl D (2012) Abnormal levels of Gadd45alpha in developing neocortex impair neurite outgrowth. PLoS ONE 7(9): e44207.

Cannon A, Yang B, Knight J, Farnham IM, Zhang Y, Wuertzer CA, D'Alton S, Lin WL, Castanedes-Casey M, Rousseau L, Scott B, Jurasic M, Howard J, Yu X, Bailey R, Sarkisian MR, Dickson DW, Petrucelli L, Lewis J. Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction. Acta Neuropathologica 2012; 807-23.

2011

Wang Y, Yin X, Rosen G, Gabel L, Guadiana SM, Sarkisian MR, Galaburda AM, LoTurco JJ. Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of Dcx. Neuroscience 2011; 190: 398-408.

Anastas SB, Mueller D, Semple-Rowland SL, Breunig JJ, Sarkisian MR. Failed cytokinesis of neural progenitors in citron kinase deficient rats leads to multi-ciliated neurons. Cerebral Cortex 2011; 21:338-344. *featured on cover above

2010

Sarkisian MR. Discs large 5: a new regulator of Citron kinase localization in developing neocortex: comment on: Chang Y, et al. Cell Cycle 2010; 9:1990-7.Cell Cycle 2010; 1876.

Links to Additional Publications

PubMed

Google Scholar Citations - Sarkisian MR