Electron Cryomicroscopy of Macromolecular Machines

Our group studies the structure and function of macromolecular assemblies using electron cryomicroscopy (cryo-EM), image analysis, molecular biology and molecular genetics. We also develop the tools of cryo-EM so that we can answer questions that are not amenable to the techniques that currently exist. This process usually occurs at the level of developing new algorithms and software for image analysis and performing calculations with images and models of molecular structure.

Our main group page is housed on the server for The Hospital for Sick Children. Group members can also access our Private Group Page.

The primary purpose of this unofficial webpage is to disseminate original software developed in the laboratory for computational analysis of cryo-EM images.  This software is provided as source code and is without any guarantee of support.

Many of the programs have been described in the scientific literature.  A publications page is also provided to help with citation information for these programs.