Welcome to my website!

I am a Researcher at the Institute of Neuroscience (IN) of the National Research Council (CNR). My activity is based in Padua, Italy, where I work with Andrea Mari and colleagues.

My current main research interests are two: mathematical modeling of glucose metabolism and its application to drug development in the diabetes therapeutic area; non-linear mixed-effect (population) modeling and its application to pharmacometrics, or more generally pharmacokinetics - pharmacodynamics analyses. Please use the Publications link to have more details on my research work.

An interested reader can have a look at the following web pages to have a grasp of the concepts above: a basic demonstrative examples of mathematical models describing the dynamics of biological systems; a paper exemplifying how mixed-effect modeling can aid the analysis of individual cell identity; some model implementations used to characterize the pathophysiology of the glucose-insulin system.

Since March 2018 I have been working for the IMI project DIRECT, aimed at the identification and validation of important biomarkers for glycaemic deterioration and treatment response to be used to predict and monitor the effect of therapeutic interventions in subtypes of diabetes with different pathophysiology. From 2011 to 2017 I have been actively involved in the IMI project DDMoRe, aimed at developing a drug-disease model library and a framework for modeling and simulation of pathophysiological processes and for the analysis of clinical studies outcomes.

Between 2008 and 2010 I was a PhD student at the Department of Information Engineering (DEI) of the University of Padua (Information Engineering School, Bioengineering specialization), under the supervision of Prof. Claudio Cobelli. In those years my research focused on Markov models of sleep data. I worked together with the Clinical Pharmacology & Modeling and Simulation group at the GlaxoSmithKline center for Drug Discovery in Neuroscience in Verona, and with the Pharmacometrics group led by Prof. Mats Karlsson at the University of Uppsala.

I have a Master Degree cum laude in Bioengineering from the University of Padova, obtained after discussing a thesis on physiologically-based pharmacokinetic modelling in drug discovery.

My institutional webpage is located at the website of the Institute of Neuroscience. For anything else, please contact me.