People
Dr. Ravi Kanth Kamlekar
Dr. Ravi Kanth Kamlekar was born in the Mahabub Nagar. After his schooling and Intermediate studies, he did graduation in science from Osmania University (1995), and B. Ed. from Kakatiya University (1996). He did his M. Sc. from Sri Krishna Devaraya University & M.Phil from the University of Hyderabad (2001), subsequently finishing the Ph. D. under the supervision of Prof. Musti. J Swamy at chemistry dept. (University of Hyderabad, Feb 2007). After his Ph.D., he joined Prof. Rhoderick. E. Brown’s research group at the Hormel Institute (University of Minnesota, Austin, MN USA) as a Hormel Fellow. There, his research is focused to elucidate the molecular basis of the decreased transfer activity of Glycolipid transfer protein-containing point mutations in their ligand sites and biophysical studies of sphingolipid binding/transfer proteins.
In July 2011, he joined as a Research Scientist at Zydus Research Center, Ahmedabad, India. There he established a Molecular Biophysics lab and developed binding/screening assays for Protein-Small Molecule Interactions, Biosimilars & Therapeutic Proteins. In 2013, he joined as an Asst. Professor (Sr.) in the Chemistry Dept., School of Advanced Sciences (SAS), VIT Vellore and was promoted as Associate Profesor in 2022. He has joined as a Regional Director, IGNOU R.C. Bijapur in Dec 2023.
He was awarded JRF & SRF by Council for Scientific and Industrial Research, India. Besides Bio-active Membrane Lipid Biophysical Studies, Lipid-Protein Interaction, and Lipid Transfer Proteins, his areas of research interests include Small Molecule Synthesis, Liposome Drug Delivery, and Protein Biochemistry. He has authored/co-authored over 35 research papers and reviews in these areas.
“Structure activity studies of a plant proteins (Lectins)”
Graduate Students
Dr. Sukanya Arul Prakash (2015-2021)
Ph.D. Thesis Title: "Structure-Activity Studies of Bioactive Fatty Acid Amides: N-acyltaurines"
1. Structure and Characterization of Catanionic Complexes and Biocompatible Vesicles of N-Acyltaurine and Sarcosine Alkyl Ester: Encapsulation and Release Studies with 5-Fluorouracil. Ravindar Chinapaka, Sukanya Prakash, Dokku Sivaramakrishna, Ravi Kanth Kamlekar*, Musti Swamy* (2024) ACS Applied Bio Materials. (Accepted). ISSN: 2576-6422 (Online) (Impact Factor 2022: 4.6)
2. Crystal structure, molecular packing, and intermolecular interactions of N-pentadecanoyltaurine and N-acyltaurine's interaction with cholesterol. Sukanya Arul Prakash, Chinapaka Ravindar, Martin Luther John, Somnath Dey* and Ravi Kanth Kamlekar* (2023) CrystEngComm, 25, 5286-5295. https://doi.org/10.1039/D3CE00646H ISSN: 1466-8033 (Impact Factor 2022: 3.1)
3. Interaction of sugar stabilised silver nanoparticles with Momordica charantia seed lectin, a type II ribosome inactivating protein. Roopa Kenoth*, Arya K Sreekumar, A. Sukanya, A. Anand Prabu, R. K. Kamlekar* (2023) Glycoconjugate Journal. 40: 179-189, https://doi.org/10.1007/s10719-023-10107-w Online ISSN:1573-4986, Print ISSN:0282-0080 (Impact Factor 2022: 3.00).
4. Interaction of N-acyltaurines with phosphatidylcholines. A. P, Sukanya, S. Megarajan, L.J. Martin, V. Anbazhagan, R. K. Kamlekar* (2022) Biochimica et Biophysica Acta (BBA) - Biomembranes. 1865 (3): 184103. https://doi.org/10.1016/j.bbamem.2022.184103 ISSN: 0005-2736. (Impact Factor 2022: 3.40)
5. Function and therapeutic potential of N-acyl amino acids. A. P, Sukanya, R. K. Kamlekar* (2021) Chem. Phys. Lipids, 239: 105114 https://doi.org/10.1016/j.chemphyslip.2021.105114 ISSN: 0009-3084 (Impact Factor 2022: 3.40)
6. Characterization of the molecular packing, thermotropic phase behaviour and critical micellar concentration of a homologous series of N-acyltaurines (n = 9-18). PXRD, DSC and fluorescence spectroscopic studies. A. P, Sukanya, R. K. Kamlekar* (2020) Chemistry and Physics of Lipids. 230: 104929. (Impact Factor 2022: 3.40) https://doi.org/10.1016/j.chemphyslip.2020.104929 ISSN: 0009-3084
7. Effective elimination of biofilm formed with waterborne pathogens using copper nanoparticles. S Megarajan, S. B. Subramaniyan, A. P. Sukanya, R.K. Kamlekar, V Anbazhagan* (2019) Microbial Pathogenesis 127: 341-346. (Impact Factor 2022: 3.8). https://doi.org/10.1016/j.micpath.2018.12.025 Online ISSN: 0882-4010
Martin L
Ph.D Student - 2021
Crystal structure, molecular packing, and intermolecular interactions of N-pentadecanoyltaurine and N-acyltaurine's interaction with cholesterol. Sukanya Arul Prakash, Chinapaka Ravindar, Martin Luther John, Somnath Dey* and Ravi Kanth Kamlekar* (2023) CrystEngComm, 25, 5286-5295. https://doi.org/10.1039/D3CE00646H ISSN: 1466-8033 (Impact Factor 2022: 3.1)
Interaction of N-acyltaurines with phosphatidylcholines. A. P, Sukanya, S. Megarajan, L.J. Martin, V. Anbazhagan, R. K. Kamlekar* (2022) Biochimica et Biophysica Acta (BBA) - Biomembranes. 1865 (3): 184103. https://doi.org/10.1016/j.bbamem.2022.184103 ISSN: 0005-2736. (Impact Factor 2022: 3.40)
Surendra P
Ph.D Student - 2021
Spectroscopic and thermodynamic characterization of the interaction between sugar-stabilised silver nanoparticles and wheat germ agglutinin (WGA), a chitin binding lectin. R Kenoth*, S Pothuraju, Anand Prabu A, RK Kamlekar*. (2023) Carbohydrate Research, 109014. Accepted Manuscript: https://doi.org/10.1016/j.carres.2023.109014 ISSN :1873-426X (Online) 0008-6215 (Print) (Impact Factor 2022: 3.1)
Sunitha G
Ph.D Student - 2021
