Medicinal Chemistry 

Our lab is dedicated to developing novel methods for drug discovery, working at the interface of chemistry and biology. Our key focus areas include: 

• Late-stage modification of covalent inhibitors/drugs

• Development of novel covalent inhibitors for protein targets in cancer and neurodegenerative diseases.

• Design new electrophilic warheads to enhance the potency and selectivity of covalent inhibitors.

• Novel chemistry techniques for chemical biology applications, such as proteomics, activity-based protein profiling (ABPP), turn-on fluorescent probes, prodrugs, cellular labeling with small molecule probes, live cell imaging, protein degradation kinetics, high-throughput screening assay development, and covalent docking.

• Development of novel small molecule degraders, including molecular glues and PROTACs.

• Organic Synthesis: Organo-catalysis, Iodine catalysis, and enantioselective total synthesis of natural products.