Heejin Jun

Undergraduate intern (2019. 09 ~ 2020. 02)

아산사회복지재단 의생명과학분야 장학생 선정 (2024-2025)

Graduate student (2020. 03 ~ 2025.08)

Current: Post-Doc in University of Pennsylvania, USA 

13. Eom, S., Park, S. G., Jun, H., Kim, Y., Lee, H. B., and Kang, S.,* Effective in vivo delivery of diphtheria toxin using protein cage nanoparticles for targeted cancer therapy. Acta Biomater, 2025, 202, 517-528.

12. Kim, Y.,* Mun, J., Kim, E., Roh, H., Eom, S., Jun, H., Kim, H. J., Kim, M., Jeon, J. P., Park, S. H., Min, D.,* and Kang, S.,* Compact clustering of highly oligomerized anti-DR5 nanobodies effectively drives apoptotic cancer cell death, significantly suppressing tumor growth . Nano Today, 2025, 65, 102834.

11. Kim, Y.,* Kim, J., Eom, S., Jun, H., Lee, H. B., Jeong, D., and Kang, S.,* Protein Nanoparticles Simultaneously Displaying TRAIL and EGFR-Binding Ligands Effectively Induce Apoptotic Cancer Cell Death and Overcome EGFR-TKI Resistance in Lung Cancer. ACS Appl. Mater. Interfaces, 2025, 17, 25139-25151..

10. Jang, S., Jun, H., Eom, S., Zhao, S., Murthy, N.,* Kang, S.,* and Kim, H.*  EGFR Affibody and PEG functionalized protein nanoparticles: Sustaining targeting and macrophage evasion. Int. J. Biol. Macromol., 2025, 307, 142167.

9. Jang, J. H., Kim, H., Jun, H., Park, C., Kim, J., Yeo, M., Kim, H., Shin, Y., Kang, S., Kim, E.,* and Lee, T.*  Targeting RBM39 with Tasisulam enhances TRAIL-induced apoptosis through DR5 upregulation and Bcl-2 downregulation in renal cell carcinoma. Biochem. Pharmacol., 2025, 236, 116877.

8. Eom, S., Park, S. G., Koo, Y. H., Noh, Y., Choi, C., Kim, Y., Jun, H., Cha, C., Joo, J., and Kang, S.* In Situ Forming and Self-crosslinkable Protein Hydrogels for Localized Cancer Therapy and Topical Wound Healing. J. Control. Release, 2025, 378, 460-475.

7. Eom, S., Jun, H., Kim, E., Kim, D., Kim, H., and Kang, S.* Developing Porous Protein Cage Nanoparticles as Cargo-loadable and Ligand-displayable Modular Delivery Nanoplatforms. ACS Appl. Mater. Interfaces, 2024, 16, 58464-58476.

6. Jun, H., Yeo, M., Jeon, J. P., Eom, S., Kim, H. J., Kim, Y., Jang, E., Park, S. H., Kim, E., and Kang, S.* CD13-targeting and TRAIL-displaying Protein Nanoparticles Effectively Induce Apoptotic Cell Death of Acute Myeloid Leukemia, Prolonging Survival in Mouse Models. Nano Today, 2024, 59, 102474.

한국을 빛낸 사람들 (BRIC) 소개 

5. Park, S. G.,# Kim, H. J.,# Lee, H. B., Eom, S., Jun, H., Jang, Y., Park, S. H.* and Kang, S.* Protein cage nanoparticle-based NK cell-engaging nanodrones (NKeNDs) effectively recruit NK cells to target tumor sites and suppress tumor growth. Nano Today, 2024, 54, 102075.

4. Kang, Y., Yeo, M., Choi, H., Jun, H., Eom, S., Park, S. G., Yoon, H., Kim, E.,* and Kang, S.* Lactate Oxidase/vSIRPa Conjugates Efficiently Consume Tumor-produced Lactate and Locally Produce Tumor-necrotic H2O2 to Suppress Tumor Growth. Int. J. Biol. Macromol., 2023, 2023, 231, 123577.

3. Park, S. G., Kim, H., Jun, H., Choi, S. Y., Kim, E.,* and Kang, S.*  Directing Ricin-based Immunotoxins with Targeting Affibodies and KDEL Signal Peptide to Cancer Cells Effectively Induces Apoptosis and Tumor Suppression. J. Nanobiotechnology, 2022, 20, 387.

2. Jun, H., Jang, E., Kim, H., Yeo, M., Park, S. G., Lee, J., Shin, K. J., Chae, Y. C. Kang, S.,* and Kim, E.* TRAIL & EGFR Affibody Dual-display on a Protein Cage Nanoparticle Synergistically Suppresses Tumor Growth. J. Control. Release, 2022, 349, 367-378.

한국을 빛낸 사람들 (BRIC) 소개

1. Kim, H., Jin, S., Choi, H., Kang, M., Park, S. G., Jun, H., Cho, H., and Kang, S.,* Target-Switchable Gd(III)-DOTA/Protein Cage Nanoparticle Conjugates with Multiple Targeting Affibody Molecules as Target Selective T1 Contrast Agents for High-field MRI.  J. Control. Release, 2021, 335, 269-280.