Nature's architectures for our own good
Our researches focus on utilizing protein based nanobio-templates for biomedical and biomaterial applications. To achieve these goals, we are using various types of nanobio-templates, such as viral capsids, small protein cages, and functional proteins, and biophysical and biochemical methods to elucidate their functions.
1. Protein Cage Engineering
Protein cage architecture has three modifiable surfaces; exterior, interior and subunit-subunit interfaces. These surfaces can be modified both genetically and chemically on demand. We can engineer these three surfaces for the purposes listed below by design.
Nano-reactors, multifunctional nano-carriers, and nano-building blocks
2. Targeted Delivery of Therapeutic or Diagnostic Reagents
Nanobio-templates can be utilized as multivalent and targeted delivery vehicles through genetic and chemical modifications. Well defined 3-D structure and multiple addressible sites are beneficial for multi-functional nanoplatforms.
Targeted delivery in vitro & in vivo
3. Protein engineering: Biosensings & Imaging
Binding specificity and high affinity to any given target molecule are essential features for in vitro and/or in vivo diagnostics and for many other biotechnological and biomedical applications. Protein engineering allows constructing multifunctional biosensing & imaging components.
Secondary antibody mimics
Plug-and-Playable Imaging Toolkits