Research

단백질 나노바이오 연구실 
열정적이며 창의적인 대학원생을 기다립니다.  

Nature's architectures for our own good

Our researches focus on utilizing protein based nanobio-templates for  biomedical and biomaterial applications. To achieve these goals, we are using various types of nanobio-templates, such as viral capsids, small protein cages, and functional proteins, and biophysical and biochemical methods to elucidate their functions.

 

1. Protein Cage Engineering

 Protein cage architecture has three modifiable surfaces; exterior, interior and subunit-subunit interfaces. These surfaces can be modified both genetically and chemically on demand. We can engineer these three surfaces for the purposes listed below by design.

 
Nano-reactors, multifunctional nano-carriers, and nano-building blocks
 
 
2. Targeted Delivery of Therapeutic or Diagnostic Reagents
 
 Nanobio-templates can be utilized as multivalent and targeted delivery vehicles through genetic and chemical modifications. Well defined 3-D structure and multiple addressible sites are beneficial for multi-functional nanoplatforms.
Targeted delivery in vitro & in vivo
Antigen-delivery 
In vivo MR imaging

3. Protein engineering: Biosensings & Imaging 

 Binding specificity and high affinity to any given target molecule are essential features for in vitro and/or in vivo diagnostics and for many other biotechnological and biomedical applications. Protein engineering allows constructing multifunctional biosensing & imaging components. 

Secondary antibody mimics

Plug-and-Playable Imaging Toolkits