Publications

2024

3. Base-Promoted Structural Rearrangement of Ynamide and Simultaneous N-Desulfonylation. Mohana Reddy Mutra, T. L. Chandana, Chung-Wei Chang, and Jeh-Jeng Wang* "Advanced Synthesis & Catalysis", 2024, ASAP doi/10.1002/adsc.202301483 ."

2. A Regioselective [3 + 2] Cycloaddition of Alkynols and Ketones To Access Diverse 1,3-Dioxolane Scaffolds. Ganesh Kumar Dhandabani, Palaniraja Jeyakannu, Chia-Ling Shih, Aksa Mariyam Abraham, Gopal Chandru Senadi, and Jeh-Jeng Wang* J. Org. Chem. 2024, 89, 719−724.

Photochemical Radical Bicyclization of 1,5-Enynes: Divergent Synthesis of Fluorenes and Azepinones. Babasaheb Sopan Gore, Chun-Cheng Chen, Ping-Yu Lin, and Jeh-Jeng Wang* Org. Lett. 2024, 26, 757-762.

2023

7. Visible light-driven highly atom-economic divergent synthesis of substituted fluorenols and cyclopropylcarbaldehydes Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo and Jeh-Jeng Wang* Green Chemistry, 2024, 26, 513–519.

6. Green and rapid acid-catalyzed ynamide skeletal rearrangement and stereospecific functionalization with anisole derivatives Mohana Reddy Mutra, T. L. Chandana, Yun-Jou Wang and Jeh-Jeng Wang Green Chemistry, 2023, 25, 8124-8133.

5. Photocatalyst- and transition-metal-free syntheses of furan-fused dihydroazepines by visible light Babasaheb Sopan Gore*, Chiao-Ying Kuo and Jeh-Jeng Wang* Green Chemistry, 2023, 25, 8074-8081.

4. Light-mediated sulfonyl-iodination of ynamides and internal alkynes Mohana Reddy Mutra, Jing Li and Jeh-Jeng Wang* Chemical Communications 2023, 59, 6584-6587.

3. Opportunities and challenges in photochemical activation of π-bond system using common transition-metal-catalyzes as a seminal photosensitizer Ganesh Kumar Dhandabani, Pei-Wen Hsieh,* and Jeh-Jeng Wang * Photochemical Reviews 2023

2. Visible light-induced oxidant/additive-free atom-economic synthesis of multifunctionalized cyclopropanes via energy transfer Babasaheb Sopan Gore and Jeh-Jeng Wang* Chemical Communications 2023, 59, 5878-5881.

1. Photoinduced Radical Cyclization of 1,6-Diynes: Rapid Access to Highly Substituted Carbocyclic and Heterocyclic Compounds Mohana Reddy Mutra, Yu-Ting Chen, and Jeh-Jeng Wang* Advanced Synthesis & Catalysis 2023 , 365, 1012–1019.

2022

5. Selective C3-nitrosation of imidazopyridines using AgNO3 as the NO source

Vishal Suresh Kudale, Ching-Piao Chu , and Jeh-Jeng Wang*, New J. Chem. 2022, 46, 15200-15204

4. Time-Atom Economical Regio-and Chemoselective Radical Cyclization of Unactivated 1,6-Enynes under Metal- and Oxidant-free Conditions

Mohana Reddy Mutra, Jing Li, Yu-Ting Chen and Jeh-Jeng Wang*, Chem. Eur. J. 2022, e202200742. doi.org/10.1002/chem.202200742

3. Photoinduced ynamide structural reshuffling and functionalization.

Mohana Reddy Mutra and Jeh-Jeng Wang*, Nature Communications, 2022, 13, 2345.

2. Visible light-assisted Ni-/Ir-catalysed atom-economic synthesis of spiro[furan-3,10 -indene] derivatives.

Babasaheb Sopan Gore, Chiao-Ying Kuo and Jeh-Jeng Wang*, Chem. Commun., 2022,58, 4087-4090.

1. A Metal-Free Strategy for the Cross-Dehydrogenative Coupling of the 1, 3-Dicarbonyl Compounds with 2-Methoxyethanol

Vishal Suresh Kudale, Sheng Zheng, Sheng-Hua Huang, Yu-Lun Chang and Jeh-Jeng Wang*, Org. Biomol. Chem., 2022, 20, 1226-1230.

2021

2.Unusual C3-Acetylation of Quinoxalin-2(1H)-one via Oxidative C–C and C–O Bond Cleavages of PEG-400.

Vishal Suresh Kudale, Mohan Reddy Mutra, Ching-Piao Chu and Jeh-Jeng Wang*, Org. Biomol. Chem., 2021,19, 5567-5571.

1. Unraveling innate substrate-controlled arylation and bicyclization of 1,5-enynes with α,β conjugates: synthesis of substituted benzo[a]fluorenes.

Babasaheb Sopan Gore, Jun-Hao Lin and Jeh-Jeng Wang* Green Chem., 2021,23, 4144-4149.

2020

9. De Novo Protocol for the Construction of Benzo[a]fluorenes via Nitrile/Alkene Activation.

Babasaheb Sopan Gore, Chun-Hsien Chiang, Chein Chung Lee, Yi-Lun Shih, and Jeh-Jeng Wang* Org. Lett., 2020, 22, 7848-7852.

8. Metal-Free Solvent/Base-Switchable Divergent Synthesis of Multisubstituted Dihydrofurans.

Babasaheb Sopan Gore, Chiao-Ying Kuo, Amol Milind Garkhedkar, Yu-Lun Chang and Jeh-Jeng Wang* Org. Lett., 2020, 22, 6160-6165.

7. Metal-free C-H methylation and acetylation of Heteroarenes with PEG-400.

Vishal Suresh Kudale and Jeh-Jeng Wang*, Green Chem., 2020, 22, 3506-3511.

6. An Efficient Approach to Functionalized Indoles from λ3-Iodanes via Acyloxylation and Acyl Transfer.

Planiraja Jeyakannu, Gopal Chandru Senadi, Chun-Hsien Chiang, Ganesh Kumar Dhandabani, Yu-Ching Chang and Jeh-Jeng Wang*, Adv. Synth. Catal., 2020., 362, 2911-2920.

5. Lewis Acid-Catalyzed Atom-Economic Synthesis of C2-Substituted Indoles from o-Amido Alkynols.

Amol Milind Garkhedkar, Babasaheb Sopan Gore, Wan-Ping Hu and Jeh-Jeng Wang* Org. Lett., 2020, 22, 3531-3536.

4. DBU‐Promoted Synthesis of 1,3‐Benzoxazines from Geminal Dibromo Olefins: Applications to the Construction of o‐Amido Phenacyl Bromides.

Amol Milind Garkhedkar, Ya‐Chi Chiang, Gopal Chandru Senadi, and Jeh‐Jeng Wang and Wan‐Ping Hu* Chemistryselect, 2020,5,3778-3783.

3. Alkene Versus Alkyne Reactivity in Unactivated 1,6-Enynes: Regioand Chemoselective Radical Cyclization with Chalcogens under metal- and oxidant-free conditions

Mohana Reddy Mutra, Vishal Suresh Kudale, Wu-Hsun Tsai and Jeh-Jeng Wang* Green Chem., 2020,22,2288-2300.

2. Acid-Promoted Intramolecular Decarbonylative Coupling Reactions of Unstrained Ketones: A Modular Approach to Synthesis of Acridines and Diaryl Ketones

Ganesh Kumar Dhandabani, Chia-Ling Shih, and Jeh-Jeng Wang* Org. Lett., 2020,22,1955-1960.

1. Regio- and Chemoselective Synthesis of Nitrogen-Containing Heterocycles via the Oxidative Cascade Cyclization of Unactivated 1,n-Enynes.

Mohana Reddy Mutra, Ganesh Kumar Dhandabani, Jing Li and Jeh-Jeng Wang* Chem.comm.,2020, 56, 2051-2054.

2019

3. FeCl3-promoted ring size-dictating diversity-oriented synthesis (DOS) of N-heterocycles using in situ-generated cyclic imines and enamines.

Ganesh Kumar Dhandabani, Mohana Reddy Mutra and Jeh-Jeng Wang* Chem.comm., 2019, 55,7542-7546.

2. Copper‐Catalyzed Synthesis of Substituted 4‐Quinolones using Water as a Benign Reaction Media: Application for the Construction of Oxolinic Acid and BQCA.

Babasaheb Sopan Gore, Chein Chung Lee, Jessica Lee and Jeh-Jeng Wang* Adv. Synth. Catal., 2019., 361, 3373-3386.

1. Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions.

Gopal Chandru Senadi, Vishal Suresh Kudale, and Jeh-Jeng Wang*, Green Chem.,2019, 21, 979-985.

2018

4. Palladium-Catalyzed Regioselective Synthesis of 1-Benzoazepine Carbonitriles from o-Alkynylanilines via 7-endo-dig Annulation and Cyanation. Ganesh Kumar Dhandabani, Mohana Reddy Mutra, and Jeh-Jeng Wang*, Adv. Synth. Catal., 2018, 360, 4754-4763.

3. Mild Access to N-Formylation of Primary Amines using Ethers as C1 Synthons under Metal-Free Conditions.

Mohana Reddy Mutra, Ganesh Kumar Dhandabani and Jeh-Jeng Wang*, Adv. Synth. Catal., 2018, 360, 3960-3968.

2. p-TsOH Promoted Synthesis of Benzo-Fused O-Heterocycles from Alkynols via Ring Contraction and C-O Scission StrategyGopal Chandru Senadi and Jeh-Jeng Wang*, Green Chem., 2018, 20, 3420-3425.

1. Synthesis of Fused-Pyrazines via Palladium-Catalyzed Double Benzyl Isocyanide Insertion and Cross-Dehydrogenative Coupling .

Gopal Chandru Senadi, Bing-Chun Guo, Yu-Ching Chang, Wan-Ping Hu, and Jeh-Jeng Wang*, Adv. Synth. Catal., 2018, 360,491–501.

2017

8. Photodynamic Therapy Using Indolines-Fused-Triazoles Induces Mitochondrial Apoptosis in Human Non-Melanoma BCC Cells.

Wan-Ping Hu, Kung-Kai Kuo, Gopal Chandru Senadi, Long-Sen Chang and Jeh-Jeng Wang, Anticancer Research, 2017, 37, 10, 5499-5055.

7. Oximes as reusable templates for the synthesis of ureas and carbamates by an in situ generations of carbamoyl oximes.

Gopal Chandru Senadi, Mohana Reddy Mutra, Ting Yi-Lu and Jeh-Jeng Wang*, Green Chem., 2017, 19, 4272-4277.

6. Efficient Approach to Amide Bond Formation with Nitriles and Peroxides: One-Pot Access to Boronated β-Ketoamides.

Babasaheb Sopan Gore, Gopal Chandru Senadi, Amol Milind Garkhedkar and Jeh-Jeng Wang*, Adv. Synth. Catal., 2017, 359, 3014–3021.

5. Pd(dba)2/tBuONO-Catalyzed Cyclization of o-Alkynylanilines with tBuONO: Synthesis and Applications of Indazole 2-oxides.Gopal Chandru Senadi, Ji-Qi Wang, Babasaheb Sopan Gore and Jeh-Jeng Wang*, Adv. Synth. Catal., 2017, 359, 2747–2753.

4.Rapid Access to Indeno[1,2-c]quinolines via Brønsted Acid- Catalyzed Cascade Reaction. Siva Senthil Kumar Boominathan, Jeh-Jeng Wang*, Adv. Synth. Catal, 2017, 359, 1844–1848

3 . Palladium-Catalyzed Double-Isocyanide Insertion via Oxidative N–O Cleavage of Acetyl Oximes: Syntheses of 2H-Pyrrol-2-imines

Gopal Chandru Senadi, Ting-Yi Lu, Ganesh Kumar Dhandabani and Jeh-Jeng Wang*, Org. Lett., 2017, 19, 1172-1175.

2.ZnBr2-Mediated Cascade Reaction of o-Alkoxy Alkynols: Synthesis of Indeno[1,2-c]chromenes

Amol Milind Garkhedkar, Gopal Chandru Senadi and Jeh-Jeng Wang*, Org. Lett., 2017, 19 (3), 488–491.

1.A Simple and Efficient Method for Constructing Azepino[4,5-b]indole Derivatives via Acid CatalysisSiva Senthil Kumar Boominathan, Mohan Reddy Mutra, Ruei-Jhih Hou, Hui-Fen Chen and Jeh-Jeng Wang*, Org. Biomol. Chem., 2017, 15, 1872-1875.

2016

8.Metal-free annulation/aerobic oxidative dehydrogenation of cyclohexanones with o-acylanilines: Efficient syntheses of acridinesGopal Chandru Senadi, Ganesh Kumar Dhandabani, Wan-Ping Hu, Jeh-Jeng Wang*, Green Chem., 2016, 18, 6241-6245 .

7. Iodine-promoted cyclization of N-propynyl amides and N-allyl amides via sulfonylation and sulfenylation.Gopal Chandru Senadi, Bing-Chun Guo, Wan-Ping Hu, Jeh-Jeng Wang*, Chem.Commun., 2016, 52, 11410-11413.

6. A Palladium-Catalyzed Domino Approach to 2,3-Disubstituted Benzofurans via an Intermolecular Carbopalladation/C(sp3)−H Functionalization/Isomerization Sequence.Siva Senthil Kumar Boominathan, Ruei-Jhih Hou, Wan-Ping Hu, Po-Jui Huang, Jeh-Jeng Wang*, Adv. Synth. Catal. 2016, 358, 2984

5. Halogenation of Arenes via an In situ Generated Hypohalous Acid from m-CPBA and HX: Mechanistic Insights from Cyclic Voltammetry.

Dr. Chung-Yu Chen, Dr. Gopal Chandru Senadi, Mei-Chun Liu and Prof. Jeh-Jeng Wang*, Chemistry select, 2016, 1(10), 2207-2211.

4. BF3-Etherate-Promoted Cascade Reaction of 2-Alkynylanilines with Nitriles: One-Pot Assembly of 4-Amido-Cinnolines.

Gopal Chandru Senadi, Babasaheb Sopan Gore, Wan-Ping Hu, and Jeh-Jeng Wang*†,Org. Lett., 2016, 18 (12), 2890-2893.

3. Design, Synthesis and Antimetastatic Evaluation of 1-benzothiazolylphenylbenzotriazoles for Photodynamic Therapy in Oral Cancer Cells Gopal Chandru Senadi, chieh-Ming Liao, Kung-Kai Kuo, Jian-Cheng Lin, Long-Sen Chang, Jeh Jeng Wang, Wan-Ping Hu*, MedChemComm 2016, (6), 2016.

2.Sequential, One-Pot Access to Arylated Benzoquinones/Naphthoquinones from Phenols/Naphthols

Jia-Heng Jiang, Siva Senthil Kumar Boominathan, Wan-Ping Hu, Chung-Yu Chen, Jaya Kishore Vandavasi, Ying-Ting Lin, and Jeh-Jeng Wang*, Eur. J. Org. Chem., 2016, (13), 2284-2289.

1. Design and synthesis of pyrrolobenzodiazepine-gallic hybrid agents as p53-dependent and -independent apoptogenic signaling in melanoma cellsYu-Wei Chou, Gopal Chandru Senadi, Chung-Yu Chen, Kung-Kai Kuo, Ying-Ting Lin, Jeh-Jeng Wang, Jia-Hau Lee, Ya-Ching Wang, Wan-Ping Hu, European Journal of Medicinal Chemistry, 2016, 109, 59–74

2015

12.Bis(phenylidenebenzeneamine)-1-disulfide Derivatives Induce Autophagy in Melanoma Cells Through a Mitochondria-mediated Pathway

Wan-Ping Hu, Chia-Chen Hsu, Ya-Ching Wang, Gopal Chandru Senadi, Kung-Kai Kuo, Jen-Fon Jen, Jeh-Jeng Wang*

Anticancer Research, 2015, 35, 11, 6075-6080

11. A Palladium- and Copper-Catalyzed Synthesis of Dihydro[1,2-b]indenoindole-9-ol and Benzofuro[3,2-b]indolines: Metal-Controlled Intramolecular C-C and C-O Bond-Forming Reactions

Siva Senthil Kumar Boominathan and Jeh-Jeng Wang* Chemistry - A European Journal, 2015, 21 (47), 17044-17050

(selected as a “Hot Paper” by the Editors for its importance in a rapidly evolving field of highcurrent interest)

10. Aryl λ3-Iodane-Mediated 6-exo-trig Cyclization to Synthesize Highly Substituted Chiral Morpholines

Jaya Kishore Vandavasi, Wan-Ping Hu, Gopal Chandru Senadi, Hui-Ting Chen, Hsing-Yin Chen, Kuang-Chan Hsieh and Jeh-Jeng Wang* Advanced Synthesis and Catalysis, 2015, 357 (13), 2788–2794

9. Metal-free cycloaddition to synthesize naphtho[2,3-d][1,2,3]triazole-4,9-dione

Ping-Fan Chen, Kung-Kai Kuo, Jaya Kishore Vandavasi, Siva Senthil Kumar Boominathan, Chung-Yu Chen,

Jeh-Jeng Wang* Org. Biomol. Chem., 2015, 13, 9261-9266.

8. Palladium(II)-catalysed regioselective synthesis of 3,4-disubstituted quinolines and 2,3,5-trisubstituted pyrroles from alkenes via anti-Markovnikov selectivity

Gopal Chandru Senadi, Wan-Ping Hu, Amol Milind Garkhedkar, Siva Senthil Kumar Boominathan, Jeh-Jeng Wang*

Chem. Commun., 2015, 51, 13795-73798

7. A Sequential One-pot Approach to 1,2,4,5-Tetrasubstituted-2H-imidazole Synthesis from Disubstituted Alkynes.

Siva Senthil Kumar Boominathan, Chung-Yu Chen, Po-Jui Huang, Ruei-Jhih Hou and Jeh-Jeng Wang*

New Journal of Chemistry, 2015, 39, 6914-6918

6. Au (I)-Catalyzed Synthesis of 8-Oxabicyclo[3.2.1]oct-2-enes and 9-Oxabicyclo[3.3.1]nona-2,6-dienes from Enynol via Oxonium/Prins-type Cyclization.

Jaya Kishore Vandavasi, Wan-Ping Hu, Siva Senthil Kumar Boominathan, Bing-Chun Guo, Cheng-Tien Hsiao

and Jeh-Jeng Wang* Chem. Commun., 2015, 51, 12435-12438

5. Silver(I)-Catalyzed Tandem Approach to β-Oxo Amides

Jaya Kishore Vandavasi, Cheng-Tien Hsiao, Wan-Ping Hu, Siva Senthil Kumar Boominathan, Jeh-Jeng Wang*

European Journal of Organic Chemistry, 2015, 14, 3171-3177

4. Copper-catalyzed selective C-O bond formation by oxidative α-C(sp3)-H/O-H coupling between ethers and salicylaldehydes

Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Michal Korineka, Yuan-Bin Chenga, Jeh-Jeng Wang*, Fang-Rong Chang* Tetrahedron 2015, 71 (15), 2290–2297

3. I2-TBHP-Catalyzed Oxidative Cross-Coupling of N-Sulfonyl Hydrazones and Isocyanides to 5-Aminopyrazoles

Gopal Chandru Senadi, Wan-Ping Hu, Ting-Yi Lu, Amol Milind Garkhedkar, Jaya Kishore Vandavasi and

Jeh-Jeng Wang* Organic letters, 2015, 17(6), 1521-1524. ("Featured on the "Organic Chemistry Portal" )

2. An Iron Catalyzed Cascade Approach to Benzo[b]carbazoles Synthesis followed by 1,4-Sulfonyl migration

Siva Senthil Kumar Boominathan, Gopal Chandru Senadi, Jaya Kishore Vandavasi, Jeff Yi-Fu Chen and

Jeh-Jeng Wang* Chemistry - A European Journal, 2015, 21, 3193-3197

1. Palladium(0)-Catalyzed Single and Double Isonitrile Insertion: A Facile Synthesis of Benzofurans, Indoles, and Isatins.

Gopal Chandru Senadi, Wan-Ping Hu, Siva Senthil Kumar Boominathan and Jeh-Jeng Wang*

Chemistry - A European Journal, 2015, 21, 998-1003

2014

6. A New Approach for Fused isoindolines via hexadehydro-Diels-Alder reaction (HDDA) by Fe(0) catalysis

Jaya Kishore Vandavasi, Wan-Ping Hu, Cheng-Tien Hsiao, Gopal Chandru Senadi, and Jeh-Jeng Wang*

RSC Advances, 2014, 4, 57547-57552

5. A K2CO3-Mediated Regioselective Synthesis of Indole/Pyrrole-Fused 1,4-Oxazines: An unexpected Indole-Fused Azlactone Synthesis

Jaya Kishore Vandavasi, Wan-Ping Hu, Gopal Chandru Senadi, Siva Senthil Kumar Boominathan, Hsing-Yin Chen*and Jeh-Jeng Wang*

European Journal of Organic Chemistry, 2014, 28, 6219-6226

4. Apoptosis Induced by 2-Aryl Benzothiazoles-Mediated Photodynamic Therapy in Melanomas via Mitochondrial Dysfunction

Yin-Kai Chen, Gopal Chandru Senadi, Chih-Hung Lee, Yi-Min Tsai, Yan-Ren Chen, Wan-Ping Hu,* Yu-Wei Chou, Kung-Kai Kuo, Jeh-Jeng Wang*

Chemical Research in Toxicology, 2014, 27(7), pp 1187-1198

(Yin-Kai Chen & Gopal Chandru Senadi contributed equally to this work).

3. A one-pot hypoiodite catalysed oxidative cycloetherification approach to benzoxazoles

Siva Senthil Kumar Boominathan, Wan-Ping Hu, Gopal Chandru Senadi, Jaya Kishore Vandavasi, Jeh-Jeng Wang*

Chemical Communications, 2014, 51, pp 6726-6728

2. Iron-Catalyzed Oxidative Direct α‑C−H Bond Functionalization of Cyclic Ethers: Selective C−O Bond Formation in the Presence of a Labile Aldehyde Group

Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Michal Korinek, Yuan-Bin Cheng, Jeh-Jeng Wang*, Fang-Rong Chang.

Organic letters, 2014, 16 (7), pp 1912-1915

1. Copper-Catalyzed Oxidative Coupling of Formamides with Salicylaldehydes: Synthesis of Carbamates in the Presence of a Sensitive Aldehyde Group

Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Da-Wei Chuang, Yuan-Bin Cheng, Jeh-Jeng Wang,* Fang-Rong Chang*

The Journal of Organic Chemistry., 2014, 79 (7), pp 3206-3214

2013

9. Nickel- or Palladium-Catalyzed stereoselective Synthesis of Tetrasubstituted Olefinic Indolines-Fused Triazoles: Extension to the spiroindoline Core

Gopal Chandru Senadi, Wan-Ping Hu, Siva Senthil Kumar Boominathan and Jeh-Jeng Wang*

Advanced Synthesis and Catalysis, 2013, 355(18), 3679-3693

8. Silver(I)-Catalyzed Conia-Ene Reaction: Synthesis of 3-Pyrrolines via a 5-endo-dig Cyclization

Siva Senthil Kumar Boominathan, Wan-Ping Hu, Gopal Chandru Senadi and Jeh-Jeng Wang*

Advanced Synthesis and Catalysi., 2013, 355(18), 3570-3574

(Selected by "SYNFACTS" for its important insights)

7. Metal-Free, Acid-Promoted Synthesis of Imidazole Derivatives via a Multicomponent Reaction

Chung-Yu Chen, Wan-Ping Hu, Pi-Cheng Yan, Gopal Chandru Senadi and Jeh-Jeng Wang*

Organic letters., 2013, 15(24), 6116-6119

6. Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds

Chung-Yu Chen, Pei-Hua Lee, Yong-Yong Lin, Wen-Ting Yu, Wan-Ping Hu,* Chia-Chen Hsu, Ying-Ting Lin, Long-Sen Chang, Cheng-Tien Hsiao, Jeh-Jeng Wang,* Mei-Ing Chung* Bioorganic & Medicinal Chemistry Letters, 2013, 23(24), 6854-6859

5. Efficient synthesis of quinoxalines with hypervalent iodine as a catalyst

Chung-Yu Chen, Wan-Ping Hu, Mei-Chun Liu, Pi-Cheng Yan, Jeh-Jeng Wang*, Mei-Ing Chung

Tetrahedron, 2013, 69, 9735-9741

4. A convenient method to construct (Z)-oxazines via 6-exo-dig iodocyclization and synthesis of indolin-3-one

Jaya Kishore Vandavasi, Kung-Kai Kuo, Wan-Ping Hu, Ho-Chanu Shen, Wei-Sheng Lo and Jeh-Jeng Wang*

Org. Biomol. Chem., 2013,11, 6520-6525

3.Discovery, Synthetic Methodology, and Biological Evaluation for Antiphotoaging Activity of Bicyclic[1,2,3]triazoles: In Vitro and in Vivo Studies

Hsin-Yu Hseih, Wen-Chen Lee, Gopal Chandru Senadi, Wan-Ping Hu, Tong-Rong Tsai, Yu-Wei Chou, Kung Kai Kuo, Chung-Yu Chen and Jeh-Jeng Wang* J. Med. Chem., 2013, 56(13), pp 5422-5435.

(Hsin-Yu Hseih & Wen-Chen Lee contributed equally to this work)

2. DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways

Chung-Yu Chen, Yin-Kai Chen, Jeh-Jeng Wang, Chia-Chen Hsu, Feng-Yuan Tsai, Ping-Jyun Sung, Hsien-Chang Lin, Long-Sen Chang, Wan-Ping Hu* Cell Biology and toxicology, 2013, 29(2), 85-99

1. Synthesis of fused triazolo[4,5-d]quinoline/chromene/thiochromene derivatives via palladium catalysis mediated by tetrabutylammonium iodide

Chung-Yu-Chen, Cheng-Hao Yang, Wam-Ping Hu, Jaya Kishore Vadavasi, Mei-Ing Chung and Jeh-Jeng Wang*

RSC Adv., 2013, 3, 2710-2719.

2012

5. Synthesis of Carbamates by Direct C–H Bond Activation of Formamides

Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Yu-Ming Chung, Yi-Hong Tsai, Shou-Fang Wu, Michal Korinek, Ying-Chi Du, Chi-Ting Hsieh, Jeh-Jeng Wang*, Fang-Rong Chong* European Journal of Organic Chemistry, 2012, 34, 6760-6766.

4. Ortho Amide-Directed Oxidation of Internal Aryl Alkynes Mediated by Cerium(IV) Ammonium Nitrate

Chieh-Fu Su, Wan-Ping Hu, Jaya Kishore Vandavasi, Mei-Ing Chung, Jeh-Jeng Wang*

Synlett, 2012, 23(14), 2132-2136.

3. Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3

Gopal Chandru Senadi, Wan-Ping Hu, Jia-Shing Hsiao, Jaya Kishore Vandavasi, Chung-Yu Chen and Jeh-Jeng Wang*

Organic Letters., 2012, 14(17), 4478-4481

(Selected by "SYNFACTS" for its important insights, Featured on the "Organic Chemistry Portal" )

2. A New Approach to 1,4-Oxazines and 1,4-Oxazepines via Base-Promoted Exo Mode Cyclization of Alkynyl Alcohols: Mechanism and DFT Studies

Jaya Kishore Vandavasi, Wan-Ping Hu, Hsing-Yin Chen, Gopal Chandru Senadi, Chung-Yu Chen and Jeh-Jeng Wang*

Organic Letters, 2012, 14(12), 3134-3137

(Selected by "SYNFACTS" for its important insights, Featured on the "Organic Chemistry Portal" )

1. Iodine-Catalyzed, Stereo- and Regioselective Synthesis of 4-Arylidine-4H-benzo[d][1,3]oxazines and their Applications for the Synthesis of Quinazoline 3-Oxides

Wen-Chun Lee, Ho-Chuan Shen, Wan-Ping Hu, Wei-Sheng Lo, Chebrolu Murali, Jaya Kishore Vandavasi, Jeh-Jeng Wang* Advanced Synthesis & Catalysis, 2012, 354, 11-12, 2218-2228.

2011

3. Naja nigricollis CMS-9 enhances the mitochondria-mediated death pathway in adaphostin-treated human leukaemia U937 cells

Ying-Jung Chen, Jeh-Jeng Wang, Long-Sen Chang*

Clinical an d Experimental Pharmacology and Physiology, 2011, 38(11), 755-763

2. A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling

Ming-Chu Hsieh, Wan-Ping Hu, Hsin-Su Yu, Wen-Chan Wu, Long-Sen Chang, Ying-Hsien Kao, Jeh-Jeng Wang* Toxicology and Applied Pharmacology, 2011, 255(2), 150-159

1. Efficient synthesis of unsymmetrical disulfides

Jaya Kishore Vandavasi, Wan-Ping Hu, Chung-Yu Chen, Jeh-Jeng Wang* Tetrahedron., 2011, 67(46), 8895-8901

2010

3. Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents

Wan-Ping Hu, Yin-Kai Chen, Chao-Cheng Liao, Hsin-Su YU, Yi-Min Tsai, Shu-Mei Huag, feng-Yuang Tsai, Ho-Chuan Shen, Long- Sen Chang, Jeh-Jeng Wang* Bioorganic & Medicinal Chemistry., 2010, 18(16), 6197.

2. Synthesis of Sulfur−Sulfur Bond Formation from Thioamides Promoted by 2,3-Dichloro-5,6-dicyanobenzoquinone

Wei-Shung Lo, Wan-Ping Hu, hsiao-Ping Lo, Chung-Yu Chen, Chian-Lin Kao, Jaya Kishore Vandavasi, Jeh-Jeng Wang*

Org. Lett., 2010, 12(23), pp 5570-5572

1. Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells

Ying-Jung Chen, wen-Hsin Liu, Pei-Hsiu Kao, Jeh-Jeng Wang, Long-Sen Chang*

Toxicon., 2010, 55(7), 1306-1316

2009

4. Effect of cholesterol on membrane-damaging activity of Naja nigricollis toxin γ toward phospholipid vesicles

Yi-Ling Chiou, Jeh-Jeng Wang, Long-Sen Chang Toxicon., 2009, 54(6), 772-776

3. In Vitro Activity of 2-methoxy-1,4-naphthoquinone and Stigmasta-7,22-diene-3β-ol from Impatiens balsamina L. against Multiple Antibiotic-Resistant Helicobacter pylori

Yuan-Chuen Wang, Wan-Yu Li, Deng-Chvang, Jeh-Jeng Wang, Cheng-Hsun Wu, Jyun-Ji Liao, Cheng-Kun Lin Evidence-Based complementary Alternative Medicine., 2009, Vol. 2011, Article ID 704721, 1-8

2. Synthesis and antitumor activity of novel enediyne-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids

Wan-Ping Hu, Juim-Jia Liang, Chia-Lin Kao, You-Chiang Chen, Chung-Yu Chen, Feng-Yuan Tsai, Ming-Jung Wu, Long-Sen Chang, Yeh-Long Chen, Jeh-Jeng Wang* Bioorganic & Medicinal Chemistry, 2009, 17(3), 1172-1180.

1. Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo

Chih-Hung Lee, Wan-Ping Hu, Chien-Hui Hong, Hsin-Su Yu, Wei-Ting Liao, Chung-Yu Chen, Yeh-Long Chen, Bai-Hsiun Chen, Gwo-Shing Chen, Jeh-Jeng Wang* Chemico-Biological Interactions, 2009, 180(3), 360-367

2008

5. Synthesis and biological evaluation of thiobenzanilides as anticancer agents

Wan-Ping Hu, Hsin-Su Yu, Yan-Ren Chen, Yi-Min Tsai, Yin-Kai Chen, Chao-Cheng Liao, Long-Sen Chang, Jeh-Jeng Wang* Bioorganic & Medicinal Chemistry, 2008, 16(9), 5295-5302

4. Induction of Apoptosis by DC-81-Indole Conjugate Agent Through NF-κB and JNK/AP-1 Pathway

Wan-Ping Hu, Feng-Yuan Tsai, Hsin-Su Yu, Ping-Jyun Sung, Long-Sen Chang and Jeh-Jeng Wang* Chem. Res. Toxicol., 2008, 21(7), 1330-1336.

3. B chain is a functional subunit of β-bungarotoxin for inducing apoptotic death of human neuroblastoma SK-N-SH cells

Yun-Ching Cheng, Jeh-Jeng Wang, Long-Sen Cheng* Toxicon., 2008, 51(2), 304-315

2. Genetic organization of Bungarus multicinctus protease inhibitor-like proteins

Long-sen Chang,* Jeh-Jeng Wang, Yun-Ching Cheng, Wen-Min ChouToxicon., 2008, 51 (8), 1490-1495

1. Mutations on the N-terminal region abolish differentially the enzymatic activity, membrane-damaging activity and cytotoxicity of Taiwan cobra phospholipase A2

Yi-Ling Ciou, Yun-Ching Cheng, Pei-Hsiu Kao, Jeh-Jeng Wang, Long-Sen Chang* Toxicon., 2008, 51 (8), 1490-1495

2007

2. DC-81-Indole Conjugate Agent Induces Mitochondria Mediated Apoptosis in Human Melanoma A375 Cells

Wan-Ping Hu, Hsin-Su Yu, Ping-Jyun Sung, Feng-Yuan Tsai, Yu-KAi Shen, Long-Sen Chang and Jeh-Jeng Wang* Chem. Res. Toxicol., 2007, 20(6), 905-912.

1. Helium–Neon Laser Irradiation Stimulates Cell Proliferation through Photostimulatory Effects in Mitochondria

Wan-Ping Hu, Jeh-Jeng Wang, Chia-Li Yu, Cheng-Che E Lan, Gow-Shing Chen and Hsin-Su Yu* J. Invest Dermatol., 2007, 127, 2048.

2006:

3. Diacid architecture effect on the synthesis and microstructure of rigid-rod poly(benzobisthiazole)s

Chien-Fan Chen, Lih-Jeng Juang, Tzu-Chein Hsu, Jeh-Jeng Wang, Li-Fang Wang Polymer International, 2006, 55(12), 1450-1455

2. Sinugibberosides A-E, new terpenoids with cyclic peroxyhemiketal from the soft coral Sinularia gibberosa

Shin-Pin Chen, Atallah F. Ahmed, Chang-Feng Dai, Chung-Kuang Lu, Wan-Ping Hu, Jeh-Jeng Wang and Jyh-Horng Sheu Tetrahedron 2006, 62, 6802-6807

1. Design, Synthesis, and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepine and Indole Conjugates as Anticancer Agents

Jeh-Jeng Wang*, Yu-Kai Shen, Wan-Ping Hu, Ming-Chu Hsieh, Fu-Lung Lin, Ming-Kuan Hsu and Mei-Hui Hsu J. Med. Chem., 2006, 49(4), 1442-1449

2005:

2. Briarenol A, a new diterpenoid from a gorgonian 'Briareum sp. (Briareidae)

Ping-Jyun Sung, Wan-Ping Hu, Lee-Shing Fang, Tung-Yung Fan, Jeh-Jeng Wang* Natural Product Research, 2005, 19(7), 689-694.

1. Cytotoxicities, cell cycle and caspase evaluations of 1,6-diaryl-3(Z)-hexen-1,5-diynes, 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines and their derivatives

Chi-Fong Lin, Yu-Hsiang Lo, Ming-Chu Hsieh, Yi-Hua Cheng, Jeh-Jeng Wang, Ming-Jung Wu* Bioorganic & Medicinal Chemistry, 2005, 13(10), 3665-3575

2004:

2. Novel Borane Reduction of Ether-Protected Aromatic Lactams

Wan-Ping Hu, Pei-Ching Tsai, Ming-Kuam Hsu, Jeh-Jeng Wang* J. Org. Chem., 2004, 69(11), 3983-3985

1. Involvement of cytotoxicity and variation of the mitochondrial membrane potential induced by hybrid agent

Wan-Ping Hu, Jeh-Jeng Wang,* Shu-Mei Huang, Hein-Su-Yu* Drug Development Research, 2004, 61(1), 1-5

2003:

3. Hippuristerones E−I, New Polyoxygenated Steroids from the Gorgonian Coral Isis hippuris

Jyh-Horng Sheu*, Long-Fei Huang, Shin-Pin Chen, Yi-Lea Yang, Ping-Jyun Sung, Guey-Horng Wang, Juri-Hsin Su, Chih-Hua Chao, wan-Ping Hu and Jeh-Jeng Wang J. Nat. Prod., 2003, 66(77), 917-921

2. Monocyclic Diterpene Benzenoids from Taiwanese Marine Sponge Strongylophora durissima

Ya-Ching Shen, Ching-Yeu Chen, Chaturvedula V. S. Prakash, Jeh-Jeng Wang and Meng-Chieh Hung* Chin. Pharm. J. 2003, 55(2), 135-140.

1. Biological Evaluation of an Antibiotic DC-81–Indole Conjugate Agent in Human Melanoma Cell Lines Wan-Ping Hu, Yen-Chi Chen, Jeh-Jeng Wang* The Kaohsiung Journal of Medical sciences, 2003, 19 (1), 6-11

2002:

3. Diacid architecture effect on the synthesis and microstructure of rigid-rod poly(benzobisimidazoles)

C. C. Chen, L. F. Wang, J. J. Wang, T. C. Hsu, C. F. Chen* Journal of Material Science, 2002, 37(19), 4109-4115

2. Chemical and Cytotoxic Constituents from the Stem of Machilus zuihoensis

Ming-Jen Cheng, Bolleddula Jayaprakasam, Tsutomu Ishikawa, Ian-Lih Tsai, Jeh-Jeng Wang, Ih-Sheng Chen Helvetica Chimica Acta, 2002, 85(7), 1909-1914

1. Evaluation of DNA-Binding Ability of Antibiotic DC-81 - Indole Conjugates by Restriction Endonuclease BamHI and Molecular Modeling Studies

Wan-Ping Hu, Hsin-Su yu, Ming-Chu Hsieh, Yen-Chi Chen, Jeh-Jeng Wang* Chin. Pharm. J. 2002, 54, No. 6, 465-470.

2001:

3. An Efficient Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine. Synthesis of the Antibiotic DC-81

Wan-Ping Hu, Jeh-Jeng Wang,* Fu-Lung Lin, Yu-Chen Lin, Shinne-Ren Lin, Mei-Hui Hsu

J. Org. Chem., 2001, 66(8), 2881-2883

2.Probing the Structural Diversities of Long α-Neurotoxins by Fluorescence Quenching Studies

Long-sen Chang, Shinne-ren Lin, Jeh-Jeng Wang, Chun-chang Chang Journal of Protein Chemistry, 2001, 20(2), 115-121

1. Design and Synthesis of 8-Amino-pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents

Wan-Ping HP. S. Tsai, J. J. Wang and J. T. Wu Journal of NKUAS, 2001, 31, 45-61

2000:

3. Novel Examples of 3-Aza-Grob Fragmentation

Wan-Ping Hu, Jeh-Jeng Wang* and Pei-Ching Tsai J. Org. Chem., 2000, 65(13), 4208-4209

2. Structure–function studies on Taiwan cobra long neurotoxin homolog

Long-Sen Chang,* Chinne-ren Lin, Jeh-Jeng Wang, Wan-Ping Hu, Bin-Nan Wu, Hsein-Bin Huang

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000, 1480(1-2),

293-301

1. New Meroditerpenoids from a Taiwanese Marine Sponge Strongylophora Durissima

Ya-Ching Shen, Meng-Cheih Hung, Chaturvedula V. S. Prakash, Jeh-Jeng Wang

Journal of Chinese Chemical Society., 2000, 47(3), 567-570

1999:

2. Chemistry and biological activities of constituents from Morus australis

Horng-Huey Ko, Jeh-Jeng Wang, Hsein-Cheng Lin, Jih-Pyang Wang, Chun-Nan Lin* Biochimica et Biophysica Acta, 1999, 1428, 293-299.

1. Novel 3-Aza-Grob Fragmentation in Hydride Reduction of Ether-Protected Aromatic Lactams

Jeh-Jeng Wang* and Wan-Ping Hu, J. Org. Chem., 1999, 64, 5725-5727

1998:

4. Synthesis and Anti-inflammatory Effect of Chalcones and Related Compounds

Hsin-Kaw Hsieh,Tai-Hua Lee, Jih-Pyang Wang, Jeh-Jeng Wang, Chun-Nan Lin, Pharmaceutical Research, 1998, 15, 39-46.

3. The Rhamnose Moiety of Solamargine Plays a Crucial Role in Triggering Cell Death by Apoptosis

Li-Ching Chang, Tong-Rong Tsai, Jeh-Jeng Wang, Chun-Nan Lin, Kou-Wha Kuo Biochemical and Biophysical Research Communications, 1998, 242, pp 21-25

2. Stereochemistry and biological activities of constituents from Cynanchum taiwanianum

Chun-Nan Lin*, Pao-Lin Huang, Jeh-Jeng Wang, Shiow-Hwa Day, Hsein

Biochimica et Biophysica Acta, 1998, 1380, pp 115-122.

1. A new and novel amide bond cleavage of N-methoxymethylpyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones by hydride reduction via 3-aza-Grob fragmentation

Jeh-Jeng Wang, Wan-Ping Hu, Hung-Wei Chung, Li-Fang Wang, Mei-Hui Hsu Tetrahedron, 1998, 54, pp 13149-1315

1997:

1. Polygonapholine, an alkaloid with a novel skeleton, isolated from Polygonatum alte-lobatum

Chun-Nan Lin, Pao-Lin Huang, Chai-Ming Lu, Ru-Rong Wu, Wan-Ping Hu, Jeh-Jeng Wang* Tetrahedron, 1997, 53, 2025-2028

1994:

2. Comparison of a DSB-120 DNA Interstrand Cross-Linked Adduct with the Corresponding Bis-tomaymycin Adduct: An Example of a Successful Template-Directed Approach to Drug Design Based upon the Monoalkylating Compound Tomaymycin

John A. Mountzouris, Jeh-Jeng Wang, David Thurston, Laurence H. Hurley* J. Med. Chem., 1994, 37(19), pp 3132-3140

1. Synthesis of 4-amino 3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate, the biosynthetic precursor of C7N units in ansamycin antibiotics

Andreas Kirschning, Philippe Bergon, Jeh-Jeng Wang, Steven Breazeale* Carbohydrate Research, 1994, 256, 245-256

1992:

2. Formation of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibiotics, by a new variant of the shikimate pathway

C.G. Kim, A. Kirsching, P. Bergon, Y. Ahh, Jeh-Jeng Wang, M. Shibuya, H.G. Floss* J. Am. Chem. Soc., 1992, 114(12), pp 4941-4943.

1. Template-directed design of a DNA-DNA crosslinker based upon a bis-tomaymycin-duplex adduct

Jeh-Jeng Wang, G. Craig Hill, Laurence H. Hurley,* J. Med. Chem., 1992, 35(16), pp 2995-3002