Publications

per-Axon diffusivities on Human Connectome data with zonal harmonics modeling

Pizzolato, M., Canales-Rodriguez, E. J., Andersson, M., & Dyrby, T. B. (2022). Axial and radial axonal diffusivities from single encoding strongly diffusion-weighted MRI. Arxiv (https://arxiv.org/abs/2207.02526)

The axial and radial diffusivities of axons in the brain's white matter are estimated from two-shell PGSE data from the MGH Adult Diffusion dataset of the Human Connectome Project.

This is the first method that enables estimating the axial diffusivity of axons from single encoding diffusion-weighted data. This is based on modeling the axonal signal with zonal harmonics.

per-Axon T2 with spherical variance

Pizzolato, M., Andersson, M., Canales-Rodriguez, E. J., Thiran, J. P., & Dyrby, T. B. (2021). Axonal T2 estimation using the spherical variance of the strongly diffusion-weighted MRI signal. Magnetic resonance imaging (https://doi.org/10.1016/j.mri.2021.11.012)

Axonal T2 can be estimated by isolating the axonal signal contribution using a strong diffusion weighting (high b-value). However, cellular compartments and vacuoles can also be present. As these can be described by isotropic diffusion signal contributions, using the variance - instead of the mean as conventionally done - we lose sensitivity to them, thus effectively isolating the anisotropic axonal contributions that can be used to calculate the axonal T2.  

MUltidimensional DIffusion (MUDI) Challenge

Pizzolato, M., Palombo, M., Bonet-Carne, E., Tax, C.M.W., Grussu, F., Ianus, A., Bogusz, F., Pieciak, T., Ning, L., Larochelle, H., Descoteaux, M., Chamberland, M., Blumberg, S.B., Mertzanidou, T., Alexander, D.C., Afzali, M., Aja-Fernández, S., Jones, D.K., Westin, C.F., Rathi, Y., Baete, S.H, Cordero-Grande, L., Ladner, T., Slator, P.J., Hajnal, J.V., Thiran, J.P, Price, A.N., Sepehrband, F., Zhang, F., & Hutter, J. (2020). Acquiring and Predicting Multidimensional Diffusion (MUDI) Data: An Open Challenge. In E. Bonet-Carne et al. (eds.), Computational Diffusion MRI, Mathematics and Visualization (soon at https://doi.org/10.1007/978-3-030-52893-5_17). Link to pdf. DTU Orbit.

Results of the challenge organized within MICCAI 2019 for predicting densely samples relaxation and diffusion data.

Adaptive Phase Correction for Diffusion-Weighted Images

Pizzolato M, Gilbert G, Thiran JP, Descoteaux M, & Deriche R. (2020). Adaptive Phase Correction for Diffusion-Weighted Images. NeuroImage Vol. 206, 116274. (https://doi.org/10.1016/j.neuroimage.2019.116274).

A method for estimating the phase of MRI images while accounting for the acquisition noise. This is used for phase-correcting diffusion-weighted images in order to remove the Rician bias.

Perfusion Deconvolution in Dynamic Susceptibility Contrast Imaging

Pizzolato M, Boutelier T, & Deriche R (2017). Perfusion deconvolution in DSC-MRI with dispersion-compliant bases. Medical Image Analysis, vol. 36, pp. 197-215, 2017. (https://doi.org/10.1016/j.media.2016.12.001)

A non-parametric method to estimate blood perfusion metrics in the brain while accounting for dispersion of the contrast agent (bolus dispersion).

Orientation-dispersed apparent axon diameter

Pizzolato M, Wassermann D, Deriche R, Thiran JP, Fick R (2019). Orientation-dispersed apparent axon diameter via multi-stage spherical mean optimization. Computational Diffusion MRI 2018. MICCAI 2018. Granada, Spain, pp. 91-101. Mathematics and Visualization. Springer, Cham. 2018 https://doi.org/10.1007/978-3-030-05831-9_8  https://infoscience.epfl.ch/record/257227

A method to estimate the apparent diameter of axons in the brain's white matter, using the diffusion MRI spherical mean information as part of the optimization used for estimating the parameters.

IMPORTANT ANNOUNCEMENT

The article uploaded at  https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8759338 is an INCORRECT version of the manuscript. There has been a misunderstanding in the article version with IEEE and hopefully the issue will be solved soon. In the meantime, please find the correct version at https://infoscience.epfl.ch/record/265384/files/paper_corrected.pdf

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