Publications

Publication List

Peer reviewed articles

1. Poggialini F., Governa P., Vagaggini C., Maramai S., Lamponi S., Mugnaini C., Brizzi A., Purgatorio R., De Candia M., Catto M., Dreassi E., Manetti F., Corelli F., Altomare C.D., Cappelli A., Paolino M. "Light-mediated Activation/Deactivation Control and in vitro ADMETox Profiling of a Donepezil-like Dual AChE/MAO-B Inhibitor". European Journal of Pharmaceutical Sciences (2025), 107066, DOI:10.1016/j.ejps.2025.107066.

2. Paolino M., Tassone G., Governa P., Saletti M., Lami M., Carletti R., Sacchetta F., Pozzi C., Orlandini M., Manetti F., Olivucci M., Cappelli A. "Morita–Baylis–Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands". ACS Medicinal Chemistry Letters (2025), in press, DOI: 10.1021/acsmedchemlett.4c00479.

3. Borgonetti V., Governa P., Morozzi M., Sasia C., Videtta G., Biagi M., Galeotti N. “A Standardized Extract of Zingiber officinale Roscoe Regulates Clinical and Biological Outcomes in Two Different EAE Mouse Models”. Biomedicines (2025), 13, 278.

4. Arvia R., Biagi M., Baini G., Cappellucci G., Governa P., Balatri S., Zakrzewska K. "Hylotelephium telephium (L) H. Ohba leaves juice improves herpetic lesions: new findings from in vitro investigations". Natural Product Research (2024), https://doi.org/10.1080/14786419.2024.2423378.

5. Di Maria S., Passannanti R., Poggialini F., Vagaggini C., Serafinelli A., Bianchi E., Governa P., Botta L., Maga G., Crespan E., Manetti F., Dreassi E., Musumeci F., Carbone A., Schenone S. "Applying molecular hybridization to design a new class of pyrazolo[3,4-d]pyrimidines as Src inhibitors active in hepatocellular carcinoma". European Journal of Medicinal Chemistry (2024), 280, 116929.

6. Governa P., Biagi M., Manetti F., Forli S. "Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors". RSC Medicinal Chemistry (2024), 15, 724-732. 

7. Aslan H., Renzi G., Angeli A., D'Agostino I., Ronca R., Massardi M., Tavani C., Carradori S., Ferraroni M., Governa P., Manetti F., Carta F., Supuran C.T. "Benzenesulfonamide Decorated Dihydropyrimidin(thi)ones: Carbonic Anhydrase Profiling and Antiproliferative Activity". RSC Medicinal Chemistry (2024), 15, 1929-1941.

8. Wozniak J.M., Li W., Governa P., Chen, L., Jadhav A., Dongre A., Forli F., Parker C,G. "Enhanced mapping of small-molecule binding sites in cells". Nature Chemical Biology (2024),  20, 823-834.

9. Borgonetti V., Caroli C.,  Governa P., Brighenti V., Pollastro F., Franchini S., Manetti F., Les F., López V., Pellati F., Galeotti N. "Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol". Phytotherapy Research (2023), 37(10), 4304–4320

10. Tamburello M.,  Salamone S., Anceschi L., Governa P., Brighenti V,. Morellini A., Rossini G., Manetti F., Gallinella G., Pollastro F., Pellati F.  "Antiviral Activity of Cannabidiolic Acid and Its Methyl Ester against SARS-CoV-2". Journal of Natural Products (2023), 86, 7, 1698–1707.

11. Governa P.°*, Romagnoli G.°*, Albanese P., Rossi F., Manetti F., Biagi M. "Effect of in vitro simulated digestion on the anti-Helicobacter Pylori activity of different Propolis extracts". Journal of Enzyme Inhibition and Medicinal Chemistry (2023), 38(1): 2183810.

12. Borgonetti V.°, Governa P.°., Manetti F., Galeotti N. "Zingiberene, a non-zinc-binding class I HDAC inhibitor: a novel strategy for the management of neuropathic pain". Phytomedicine (2023), 111:154670.

13. Pressi G., Rigillo G., Governa P., Borgonetti V.,  Baini G., Rizzi R., Guarnerio C., Bertaiola O., Frigo M., Merlin M., Paltrinieri S., Zambonin R., Pandolfo S., Biagi M., Basnet S. "A Novel Perilla frutescens (L.) Britton Cell-Derived Phytocomplex Regulates Keratinocytes Inflammatory Cascade and Barrier Function and Preserves Vaginal Mucosal Integrity In Vivo". Pharmaceutics (2023), 15(1), 240.

14. Borgonetti V., Anceschi L., Brighenti V., Corsi L., Governa P., Manetti F., Pellait F., Galeotti N. "Cannabidiol‐rich non‐psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2‐mediated microglial neuroinflammation". Phytotherapy Research (2023), 37(5), 1924–1937.

15. Borgonetti V., Biagi M., Galeotti N., Manetti F., Governa P.* "Investigation on the neuroprotective effect of a cannabidiol-enriched non-psychotropic Cannabis sativa L. extract in an in vitro model of excitotoxicity". Fitoterapia (2022), 163, 105315.

16. Manetti F.*, Maresca L., Crivaro E., Pepe S., Cini E., Singh S., Governa P., Maramai S., Giannini G., Stecca B.*, Petricci E.* "Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening". ACS Medicinal Chemistry Letters (2022), 13, 8: 1329–1336

17. Governa P., Bernardini G., Braconi D., Manetti F., Santucci A., Petricci E. "Survey on the Recent Advances in 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibition by Diketone and Triketone Derivatives and Congeneric Compounds: Structural Analysis of HPPD/Inhibitor Complexes and Structure–Activity Relationship Considerations". Journal of Agricultural and Food Chemistry (2022), 70(23), 6963–6981.

18. Borgonetti V., Benatti C., Governa P., Isoldi G., Pellati F., Alboni S., Tascedda F., Montopoli M., Galeotti N., Manetti F., Miraldi E., Biagi M., Rigillo G. "Non‐psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors‐, endocannabinoids‐, and NF‐κB‐mediated signaling". Phytotherapy Research (2022), 36(5), 2246– 2263.

19. Pressi G., Bertaiola O., Guarnerio C., Barbieri E., Rigillo G., Governa P., Biagi M., Guzzo F., Semenzato A. "In Vitro Cell Culture of Rhus coriaria L.: A Standardized Phytocomplex Rich of Gallic Acid Derivatives with Antioxidant and Skin Repair Activity". Cosmetics (2022), 9(1), 12.

20. Ezquerra-Aznárez JM., Degiacomi G., Gašparovič H., Stelitano G., Sammartino JC., Korduláková J., Governa P., Manetti F., Pasca MR., Chiarelli LR., Ramón-García S. "The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the Mycobacterium tuberculosis DprE1 Enzyme". International Journal of Molecular Sciences (2022), 23:771.

21. Governa P., Manetti F., Miraldi E., Biagi M. "Effects of in vitro simulated digestion on the antioxidant activity of different Camellia sinensis (L.) Kuntze leaves extracts". European Food Research and Technology (2022), 248, 119–128.

22. Governa P., Manetti F. "Recent research results have converted gp120 binders to a therapeutic option for the treatment of HIV-1 infection. A medicinal chemistry point of view". European Journal of Medicinal Chemistry (2021), 229:114078.

23. Governa P., Caroleo M.C., Carullo G., Aiello F., Cione E., Manetti F. “FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity”. Bioorganic & Medicinal Chemistry Letters (2021), 41:127969.

24. Borgonetti V., Governa P., Manetti F., Miraldi E., Biagi M., Galeotti N. “A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor”. Journal of Pharmacy and Pharmacology (2021), 73:1161-1168

25. Cocetta V., Governa P., Borgonetti V., Tinazzi M., Catanzaro D., Peron G., Berretta M., Biagi M., Manetti F., Dall'Acqua S., Montopoli M. "Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress ". Frontiers in Pharmacology (2021), 12:641210.

26. Mazzotta S.°, Governa P.°, Borgonetti V., Marcolongo P., Gamberucci A., Manetti F., Pessina F., Carullo G., Brizzi A., Aiello F. “Pinocembrin and its Linolenoyl Ester Derivative induce Wound Healing Activity in HaCaT cell line potentially involving a GPR120/FFAR4 mediated pathway”. Bioorganic Chemistry (2021), 108:104657.

27. Borgonetti V., Governa P., Biagi M., Pellati F., Galeotti N. “Zingiber officinale Roscoe rhizome extract alleviates neuropathic pain by inhibiting neuroinflammation in mice”. Phytomedicine (2020), 78: 153307.

28. Borgonetti V.°, Governa P.°, Biagi M., Galeotti N. “Novel Therapeutic Approach for the Management of Mood Disorders: In Vivo and In Vitro Effect of a Combination of L-Theanine, Melissa officinalis L. and Magnolia officinalis Rehder & E.H. Wilson”. Nutrients (2020), 12(6): 1803.

29. Borgonetti V., Cocetta V., Biagi M., Carnevali I., Governa P.*, Montopoli M. “Anti-inflammatory activity of a fixed combination of probiotics and herbal extract in an in vitro model of intestinal inflammation by stimulating Caco-2 cells with LPS- conditioned THP-1 cells medium”. Minerva Pediatrica (2020), Ahead of print, DOI: 10.23736/S0026-4946.20.05765-5.

30. Carullo G., Sciubba F., Governa P., Mazzotta S., Frattaruolo L., Grillo G., Cappello A.R., Cravotto G., Di Cocco M.E., Aiello F. “Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation of In Vitro Wound-Healing and Anti-Inflammatory Activities”. Pharmaceuticals (2020), 13(5): 97.

31. Borgonetti V.°, Governa P.°, Biagi M., Dalia P., Corsi L. “Rhodiola rosea L. modulates inflammatory processes in a CRH-activated bv2 cell model”. Phytomedicine (2020), 68: 153143.

32. Carullo G.°, Governa P.°, Spizzirri U.G., Biagi M., Sciubba F., Giorgi G., Loizzo M., Di Cocco M.E., Aiello F., Restuccia D. “Sangiovese cv pomace seeds extract-fortified kefir exerts anti-inflammatory activity in an in vitro model of intestinal epithelium using caco-2 cells”. Antioxidants (2020), 9(1): 54.

33. Governa P., Biagi M. “Copaifera langsdorffii Desf.: in vitro investigation on anti-Helicobacter pylori and anti-inflammatory activities of oleoresin and fruit methanolic extract”. Plant Biosystems (2020), 154(1): 117-124.

34. Governa P., Cusi M.G., Borgonetti V., Sforcin J.M., Terrosi C., Baini G., Miraldi E., Biagi M. “Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells”. Biomedicines (2019), 7(4): 73.

35. Carullo G.°, Governa P.°, Leo A., Gallelli L., Citrato R., Cione E., Caroleo M.C., Biagi M., Aiello F., Manetti F. “Quercetin‐3‐Oleate Contributes to Skin Wound Healing Targeting FFA1/GPR40”. ChemistrySelect (2019), 4(29): 8429-8433.

36. Borgonetti V., Governa P.*, Montopoli M., Biagi M. “Cannabis sativa L. constituents and their role in neuroinflammation”. Current Bioactive Compounds , 15(2)147-158.

37. Governa P.°, Carullo G.°, Biagi M., Rago V., Aiello F. 2019. “Evaluation of the In Vitro Wound-Healing Activity of Calabrian Honeys”. Antioxidants (2019), 8:36.

38. Cocetta V., Catanzaro D., Borgonetti V., Ragazzi E., Giron M.C., Governa P., Carnevali I., Biagi M., Montopoli M. “A Fixed Combination of Probiotics and Herbal Extracts Attenuates Intestinal Barrier Dysfunction from Inflammatory Stress in an In vitro Model Using Caco-2 Cells”. Recent Patents on Food, Nutrition & Agriculture (2019), 10(1): 62-69.

39. Chiocchio I., Poli F., Governa P.*, Biagi M., Lianza M. 2018.“Wound healing and in vitro antiradical activity of five Sedum species grown within two sites of community importance in Emilia-Romagna (Italy)”. Plant Biosystems (2019), 153(4): 610-615.

40. Governa P.*, Marchi M., Cocetta V., De Leo B., Saunders P.T.K., Catanzaro D., Miraldi E., Montopoli M., Biagi M.  “Effects of Boswellia Serrata Roxb. and Curcuma longa L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2”. Pharmaceuticals (2018), 11(4): 126.

41. Governa P.*, Baini G., Borgonetti V., Cettolin G., Giachetti D., Magnano AR., Miraldi E., Biagi M.  “Phytotherapy in the Management of Diabetes: a Review”. Molecules (2018), 23(1): 105.

42. Tsiuotsiou EE., Miraldi E., Governa P., Biagi M., Giordani P., Cornara L. “Skin Wound Healing: From Mediterranean Ethnobotany to Evidence based Phytotherapy”. Athens Journal of Sciences (2017), September 2017.

43. Governa P.*, Giachetti D., Biagi M., Manetti F., De Vico L. 2016. "Hypothesis on Serenoa repens (Bartram) Small extract inhibition of prostatic 5α-reductase through an in silico approach on 5β-reductase x-ray structure". PeerJ (2016), 4: e2698.

44. Biagi M., Pecorari R., Appendino G., Miraldi E., Magnano AR., Governa P., Cettolin G., Giachetti D. "Herbal Products in Italy: The Thin Line between Phytotherapy, Nutrition and Parapharmaceuticals; A Normative Overview of the Fastest Growing Market in Europe". Pharmaceuticals (2016), 9(4): 65.

45. Tsioutsiou EE., Giachetti D., Miraldi E., Governa P., Magnano AR., Biagi M. "Phytotherapy and skin wound healing". Acta Vulnologica (2016), 14(3): 126-139.

46. Governa P., Miraldi E., De Fina G., Biagi M. "Effectiveness of 5-pyrrolidone-2-carboxylic acid and copper sulfate pentahydrate association against drug resistant Staphylococcus strains". Natural Product Communications (2016), 11(4): 453-455.

Book Chapters

1. Petricci E., Governa P., Manetti F. “Chemical Hybridization Approaches Applied to Natural and Synthetic Compounds for the Discovery of Drugs Active Against Neglected Tropical Diseases”, in “Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents” Publisher: CRC Press (2019).

Oral presentations

1. “La fitoterapia per la gestione dell’iperglicemia: focus sulla berberina”; “XXVII Congresso nazionale di Fitoterapia” organized by Italian Society of Phytotherapy (S.I.Fit.), Best Western Classic Hotel, Reggio Emilia, Italy, 24 May 2019.

2. “New goals for phytotherapy in cosmetics: research experiences in SIFITLab”; “VI SYRP: S.I.Fit. Young Researchers Project” organized by Italian Society of Phytotherapy (S.I.Fit.), Palace Hotel, Serravalle, Republic of San Marino, 20 November 2017.

3. “New hypotheses on Serenoa repens (Bartram) Small extract mechanism of action through in silico methods”; Seminar, Department of Chemistry, Copenhagen University, Denmark, 15 July 2014.

4. “New hypotheses on Serenoa repens (Bartram) Small extract mechanism of action through in silico methods”; “Convegno Monotematico – Farmacognosia: nuove opportunità terapeutiche dal mondo vegetale” organized by Italian Society of Pharmacology (SIF), Hotel Royal Continental, Naples, Italy, 20-21 June 2014.

Scientific Posters

1. Governa P., Forli S., Manetti F. "Combining pharmacophore modeling and molecular docking for the virtual screening of targeted reactive libraries as possible covalent RIPK1 inhibitors". 27th National Meeting in Medicinal Chemistry. Bari 11-14 September 2022.

2. Governa P., Forli S., Manetti F. "Combining pharmacophore modeling and molecular docking for the virtual screening of targeted reactive libraries as possible covalent RIPK1 inhibitors". DBCF Research Day. Siena 31 May 2022.

3. Ezquerra-Aznárez JM., Degiacomi G., Gašparovič H., Stelitano G., Sammartino JC., Korduláková J., Governa P., Manetti F., Pasca MR., Chiarelli LR., Ramón-García S. "The veterinary anthelmintic selamectin inhibits the mycobacterial DprE1 enzyme". 32nd ECCMID: European Congress of Clinical Microbiology and Infectious. Lisbon 23-26 April 2022

4. Governa P., Biagi M, Manetti F, Forli S. "Structure-based identification of P-glycoprotein inhibitors from natural sources". EUROPIN Summer School on Drug Design - Vienna. Online 13-17 September 2021. 

5. Governa P., Manetti F, Biagi M. “Effect of in vitro simulated digestion on the anti-Helicobacter pylori activity of different propolis extracts”. 69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA). Online 5-8 September 2021.

6. Governa P., Biagi M., Manetti F., Forli S. “Structure-based identification of P-glycoprotein inhibitors from natural sources” EFMC-ISMC & EFMC-YMCS Virtual Poster Session. Online 9 September 2020.

7. Governa P., Biagi M., Manetti F., Forli S. “Structure-based identification of P-glycoprotein inhibitors from natural sources”. Italian Young Medicinal Chemistry Virtual Meeting. Online 22-24 June 2020.

8. Governa P., Biagi M., Manetti F. “In vitro gastrointestinal bioaccessibility as a model for exploring the pharmacokinetics properties of natural products”. I Bio.Natural Meeting 2019. Lisbona 27-28 September 2019.

9. Rigillo G., Borgonetti V., Benatti C., Governa P., Tascedda F., Biagi M. “Cannabidiol-enriched Cannabis sativa L. extract modulates inflammatory-induced human peripheral mononuclear cells respinse”. 67° International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research. Innsbruck, 1-5 September 2019.

10. Governa P., Manetti F., Miraldi E., Biagi M. “Stability and bioaccessibility of Cannabis sativa L. extracts under in vitro simulated gastrointestinal digestion”. XVI Congress of the Italian Society of phytochemistry jointly with 2nd International Congress on Edible, Medicinal and Aromatic Plants. Alghero, 19-21 june 2019.

11. Governa P., Borgonetti V., Manetti F., Biagi M. “In Vitro Neuroprotective Effect of a CBD-enriched Non-psychotropic Cannabis sativa L. Extract”. 1st International Conference on Neuroprotection by Drugs, Nutraceuticals and Physical Activity. Rimini, 6-7 June 2019.

12. Borgonetti V., Governa P., Biagi M., Galeotti N. “A Standardized Extract of Zingiber officinale Roscoe is More Effective Than its Main Constituents in Reducing Neurotoxicity In Vitro and Shows Anti-Nociceptive Activity in a Mice Model of Neuropathic Pain”. 1st International Conference on Neuroprotection by Drugs, Nutraceuticals and Physical Activity. Rimini, 6-7 June 2019.

13. Borgonetti V., Governa P., Biagi M., Galeotti N. “Neuroprotective effects of a standardized extract of Zingiber officinale Roscoe in an in vitro model of neurotoxicity”. XXVII Congresso Nazionale di Fitoterapia jointly with IX SYRP: S.I.Fit. Young Researchers Project. Reggio Emilia, 24-26 May 2019.

14. Governa P., Biagi M., Manetti F. “Evaluation of the pharmacokinetic properties of natural products: focus on bioaccessibility”. VIII SYRP: S.I.Fit. Young Researchers Project - Experimental models for the study of natural products. Imola, 14 January 2019.

15. Carullo G.°, Governa P.°, Biagi M., Manetti F., Aiello F. “Lipo-pinocembrin derivatives as new tools in wound healing drug development”. VIII SYRP: S.I.Fit. Young Researchers Project - Experimental models for the study of natural products. Imola, 14 January 2019.

16. Rigillo G., Borgonetti V., Benatti C., Governa P., Tascedda F., Biagi M. “Effect of non-psychotropic Cannabis sativa L. extract on LPS-induced microglial response”. VIII SYRP: S.I.Fit. Young Researchers Project - Experimental models for the study of natural products. Imola, 14 January 2019.

°Co-first authors; *Corresponding author