We focus on the fundamental of micro- and nano-scale science and engineering, aiming on making breakthroughs of novel alternative approaches to keep current trend of continuous size scaling down for emerging nanotechnology by circumventing fundamental physic limits such as optical diffraction and superparamagnetic effect, with emphasis on the applications of lithography, imaging and metrology for manufacturing; data storage, communication and computation for information technology; imaging and diagnosis for biology and healthcare; and nanoscale energy conversion, transfer and storage for new alternative energy.