The Biomedical Optics Research Group
Welcome to the homepage of the Biomedical Optics Research Group at Northeastern University. Our laboratory PI is Professor Mark Niedre. Our group studies the application of optical engineering to biomedicine.
By nature the field is highly inter-disciplinary and requires the integration of diverse backgrounds such as optical design, software and hardware engineering, image reconstruction, biology, chemistry, and medicine.
Recent Lab News:
September 2022
Josh's article "Near-infrared diffuse in vivo flow cytometry" published in Journal of Biomedical Optics!
June 2022
Fernando's article "Signal and Measurement Considerations for Human Translation of Diffuse in vivo Flow Cytometry (DiFC)" published in Journal of Biomedical Optics!
May 2022
Josh's preprint "Near-Infrared Diffuse In Vivo Flow Cytometry” posted to bioRxiv!
Northeastern made a video about our work!
March 2022
Fernando's preprint "Signal and Measurement Considerations for Human Translation of Diffuse in vivo Flow Cytometry (DiFC)" posted to bioRxiv!
An NIH R01 award for "Continuous, Non-Invasive Optical Monitoring of Circulating Tumor Cell-Mediated Metastasis in Awake Mice" find out more!
February 2022
Prof. Mark Niedre gave an invited talk for the Journal of Biomedical Optics Hot Topics Webinar: Seeing Inside Tissue with Optical Molecular Probes titled "Shedding Light on Circulating Tumor Cells In Vivo:Towards Real-Time CTC Enumeration with a Near-Infrared Fluorescence Molecular Probe"
January 2022
We're going to the Optica Biophotonics Congress in April! Congratulations to Amber, Fernando, and Josh for their abstracts being accepted. Amber and Josh will be each giving a presentation and Fernando will be presenting a poster
April 2021
Prof. Mark Niedre gave an invited talk at OSA Biophotonics Congress 2021 "In Vivo Labeling and Enumeration of Circulating Tumor Cells With a Folate-Receptor Targeted Molecular Probe"
January 2021:
An NIH R21 award for "Fluorescence Molecular In Vivo Liquid Biopsy of Circulating Tumor Cells" find out more!
January 2021
Malcolm Shumel, a Bioengineering undergraduate, has joined the lab
October 2020
A big congratulations to Amber Williams and our collaborator Prof. Eduardo Sontag on: "Short-term circulating tumor cell dynamics in mouse xenograft models and implications for liquid biopsy" being published in Frontiers in Oncology https://doi.org/10.3389/fonc.2020.601085
September 2020:
Josh Pace, a new Bioengineering PhD student, has joined the lab
July 2020:
New (and very cool) pre-print from Amber WIlliams' work with our collaborator Prof. Eduardo Sontag up on biorxiv: "Short-term circulating tumor cell dynamics in mouse xenograft models and implications for liquid biopsy" https://doi.org/10.1101/814368
July 2020:
Associate Professor Niedre
June 2020:
Congratulations Jessica Fitzgerald for having her paper "Heterogeneity of Circulating Tumor Cell Dissemination and Lung Metastases in a Subcutaneous Lewis lung Carcinoma Model" accepted in Biomedical Optics Express. This work was done with our collaborators from Prof. Scott C. Davis' group at Dartmouth College and Prof. Chiara Bellini at Northeastern.
April 2020:
Congratulations Jessica Fitzgerald for successfully defending her PhD!
April 2020:
Congratulations to Roshani Patil for having her paper "Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor Targeted Molecular Probe for Diffuse In VivoFlow Cytometry" accepted for publication in Molecular Imaging and Biology. This work was done with our collaborators from Prof. Phil Low's group at Purdue University. The pre-print (accepted version) is available for download here.
April 2020:
Prof. Mark Niedre give an on-line talk for OSA Biophotontics Congress 2020.
(Note: Not sure if I'm supposed to do this but I pre-recorded the talk and registration wound up being free so here it is):
OSA_Biomed_2020_CTC_Dynamics_Talk.mp4March 2020:
Congratulations to Peter Bartosik for having his paper "Prospects for the Use of Upconverting Nanoparticles as a Contrast Agent for Enumeration of Circulating Cells In Vivo" accepted in the International Journal of Nanomedicine. This work was done with our acollaborators from Prof. Sergei Vinogradov's group at University of Pennsylvania. The paper is available for download here.
Jan 2020:
Congratulations to Wenjun Di and Xuefei Tan for having their paper "Real-time particle-by-particle detection of erythrocyte- camouflaged microsensor with extended circulation time in the bloodstream" Accepted in the Proceedings of the National Academy of Sciences USA. This work was done with our acollaborators from Prof. Heather Clark's group at Northeastern. The paper is available for download here.