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Main research interest:
My main research interest is to understand how AAA+ ATPases are using ATP hydrolysis to remodel their specific substrates. Indeed, in all kingdom of life, a same structural unit (AAA+ core) is used for very versatile cellular activities (for example for transcription activation, protein degradation, or microtubule severing).

Understanding the conserved feature of such domain is critical to understand how these different molecular machines are working. In addition, more and more human diseases have been linked to defective proteins member of the AAA+ protein family. Strikingly, deep sequencing approaches have reported that the mutations responsible for the activity default were, in most of the time, located into the AAA+ core, pointing out the importance of understanding the molecular bases allowing the AAA+ core to use ATP hydrolysis and to transmit this "energy" to the remodeling motifs.

Currently, I am using the AAA+ microtubule-severing enzyme Katanin as system model.


Contact : email


Recent papers:

Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans.
Martino L, Morchoisne-Bolhy S, Cheerambathur DK, Van Hove L, Dumont J, Joly N, Desai A, Doye V, Pintard L.
Dev Cell. 2017 Oct 23;43(2):157-171.e7. doi: 10.1016/j.devcel.2017.09.019. PMID: 29065307 [PubMed - in process]

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.
Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas UV, Nadal M, Bouloc P, Dairou J, Lamouri A.
Science. 2017 Jun 8. pii: eaag1095. doi: 10.1126/science.aag1095. [Epub ahead of print] PMID: 28596309

Microtubule-severing activity of AAA-ATPase Katanin is essential for female meiotic spindle assembly.
Joly N, Martino L, Gigant E, Dumont J, Pintard L.
Development. 2016 Oct 1;143(19):3604-3614.

Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.
Thomas Y, Cirillo L, Panbianco C, Martino L, Tavernier N, Schwager F, Van Hove L, Joly N, Santamaria A, Pintard L, Gotta M.
Cell Rep. 2016 Apr 5. pii: S2211-1247(16)30320-5. doi: 10.1016/j.celrep.2016.03.049.